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Coinjection of low doses of morpholinos for beta-neurexin 1a and neuroligin 1 together or in combination with morpholinos targeting the -heparin--binding isoforms of vascular endothelial growth factor A (show VEGFA ELISA Kits) recapitulates the observed abnormalities
the expression of NL1 and its binding partner neurexin (show NRXN1 ELISA Kits)-1beta was increased in temporal lobe epileptic foci in patients and lithium-pilocarpine-treated epileptic rats.
Neuroligin 1 (NL1) promotes the formation of glutamatergic synapses and mediates long-term potentiation.
NLGN1 was associated with schizophrenia in Chinese Han Populations
Increasing expression of TGF-beta1 (show TGFB1 ELISA Kits) protein, decreasing expressions of Ghrelin (show GHRL ELISA Kits), Neurexin (show NRXN1 ELISA Kits), and Neuroligin proteins can induce the loss or dysfunction of ganglion cells in distal intestinal canal
Neuroligin-1 and Glu (show DCTN1 ELISA Kits) may represent new markers of ganglion cells, whose expression may correlate with the pathogenesis, diagnosis, differential diagnosis or classification of Hirschsprung's disease.
Results indicate that the neurexin (show NRXN1 ELISA Kits) and neuroligin synaptic complex is intrinsically involved in the regulation of DISC1 (show DISC1 ELISA Kits) function, thus contributing to a better understanding of the pathology of schizophrenia.
Monitoring the attachment and detachment of neurexin (Nrx (show NRXN1 ELISA Kits))-coated quantum dots measures the rates of neurexin (Nrx (show NRXN1 ELISA Kits))/neuroligin interaction in the hippocampus.
We identified a cluster of single nucleotide polymorphisms at the NLGN1 locus showing significant association with BP variability. Follow-up analyses did not support an association with risk of ischemic stroke and its subtypes
Expression levels of neurexin (show NRXN1 ELISA Kits) and neuroligin in ENS are significantly down-regulated in HSCR (show EDNRB ELISA Kits), which may be involved in the pathogenesis of HSCR (show EDNRB ELISA Kits).
these manipulations of NL1 function illuminate the significance of NL1 intracellular signaling in vivo, and enhance our understanding of the factors that gate the maturation of glutamatergic synapses and complex behavior
The results indicate that Nrx2alpha and NL1 (show MMEL1 ELISA Kits) are targets of Abeta (show APP ELISA Kits) oligomers and that prevention of this interaction reduces the deleterious impact of Abeta (show APP ELISA Kits) oligomers on synapses and cognition.
Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin-mediated actin reorganization.
Study shows that astrocyte-secreted hevin is a trans-synaptic linker that bridges presynaptic NRX1alpha with postsynaptic NL1B. This way, hevin organizes both pre- and postsynaptic specializations and aligns them across the synapse.
Results are indicative of an altered immediate response of the brain to peripheral stimulation in Nlgn1 KO mice, and suggest a role for NLGN1 in the regulation of cerebrovascular responses
the R451C mutation in the Nlgn3 (show NLGN3 ELISA Kits) gene, associated with autism spectrum disorder in humans, confers resistance to induced seizures
This study provided first evidence that NL1 (show MMEL1 ELISA Kits) is essential for normal excitatory transmission and long-term synaptic plasticity in the hippocampus of intact animals.
NLGN1 and alpha6 integrin preferentially colocalize in the mature retinal vessels, whereas NLGN1 deletion causes an aberrant VE-cadherin (show CDH5 ELISA Kits), laminin and alpha6 integrin distribution in vessels
This study demonistrated that amyloid-induced neuroinflammation leads to epigenetic suppression of NLGN1 expression.
This study demonstrate a direct functional interaction between CaMKII (show CAMK2G ELISA Kits) and NL-1 (show MMEL1 ELISA Kits), two primary components of excitatory synapses.
Data indicate that absence of Neuroligin-1 (NLG1) decreases wakefulness duration.
transmembrane ligand for neurexins\; involved in development and maturation of synaptic connections
, neuroligin I
, neuroligin 1 isoform A1A2B