Browse our Reelin Proteins (RELN)

Full name:
Reelin Proteins (RELN)
On www.antibodies-online.com are 17 Reelin (RELN) Proteins from 4 different suppliers available. Additionally we are shipping Reelin Antibodies (50) and Reelin Kits (30) and many more products for this protein. A total of 97 Reelin products are currently listed.
Synonyms:
LIS2, MGC172539, PRO1598, Reelen, reeler, RELN, Rl
list all proteins Gene Name GeneID UniProt
RELN 19699 Q60841
RELN 5649 P78509
RELN 24718 P58751

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Reelin Proteins (RELN) by Origin

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More Proteins for Reelin Interaction Partners

Zebrafish Reelin (RELN) interaction partners

  1. Developmental gene expression pattern of reelin, dab1 (show DAB1 Proteins), vldlr (show VLDLR Proteins), and apoer2 (show LRP8 Proteins) in the central nervous system of zebrafish was compared, and their remarkable expression was detected in the developing laminar structures and also non-laminated structures.

Mouse (Murine) Reelin (RELN) interaction partners

  1. ADAMTS-3 was identified as the protease that cleaves and inactivates Reelin in the cerebral cortex and hippocampus. ADAMTS-3 was expressed in the excitatory neurons of the embryonic and postnatal cerebral cortex and hippocampus.

  2. RELN R2290C heterozygous neurospheres reveals up-regulation of Protein Disulfide Isomerase (show P4HB Proteins) A1, best known as an endoplasmic reticulum-chaperone protein

  3. A C-terminal region truncation of the reelin protein causes abnormal phenotypes in the cerebral cortex and hippocampus.

  4. This study demonstrated that Reelin Maintain Postnatal CA1 (show CA1 Proteins) Hippocampus Integrity in mice.

  5. Sex-associated and brain region-specific differences in reelin expression appear long before Abeta (show APP Proteins)-plaque formation in AbetaPP mutant Alzheimer disease model.

  6. These findings suggest that circulating Reelin promotes atherosclerosis by increasing vascular inflammation, and that reducing or inhibiting circulating Reelin may present a novel approach for the prevention of cardiovascular disease.

  7. A new transgenic mouse model demonstrates that Reelin is a molecule which is critical for proper cortical development.

  8. androgenic hormones can influence cerebral reelin demethylation

  9. data suggest Kdm5b (show KDM5B Proteins) negatively regulates neurogenesis and represses reelin in neural stem cells from the adult subventricular zone.

  10. reveals a novel function for Reelin/ApoER2 (show LRP8 Proteins) in peripheral nervous system, inducing cell migration of Schwann cells, a process relevant for peripheral nervous system development and regeneration

Human Reelin (RELN) interaction partners

  1. Reelin is was low in primary breast cancer tissue, but higher in Her2 (show ERBB2 Proteins)(+) breast cancers (but not triple-negative ones) metastasizing to the brain, especially in the tumor periphery adjacent to surrounding astrocytes. In the neural niche, astrocytes epigenetically regulate Reelin expression and its interaction with Her2 (show ERBB2 Proteins) leading to increased proliferation and survival fitness.

  2. Heterozygous RELN mutations cause a typical Autosomal Dominant Lateral Temporal Lobe Epilepsy syndrome, indistinguishable from that associated with LGI1 (show LGI1 Proteins) mutations.

  3. We screened for mutations in RELN or VLDLR (show VLDLR Proteins) and compared the phenotype of these patients with that of previously reported patients. differences in clinical severity, involvement of the cerebellar hemispheres, together with the severity of the neocortical defect, enables RELN-mutated patients to be distinguished from VLDLR (show VLDLR Proteins)-mutated patients.

  4. Reelin signaling is a critical player in the modulation of synaptic function.

  5. Reelin was expressed by human hepatic stellate cells/myofibroblasts and the number of these cells increased significantly in the lobule as the liver fibrosis progressed, suggesting a role for Reelin in the activation of hepatic stellate cells/myofibroblasts during liver injury.

  6. The presence of reelin was elevated in junctional areas as in dysplastic nevi. VLDLR (show VLDLR Proteins) presented positive values in 16 cases (16/ 32) and ApoER2 (show LRP8 Proteins) was weak positive in 7 cases.

  7. common variants of GABRG2 (show GABRG2 Proteins), RELN and NRG3 (show NRG3 Proteins) and the GABRG2 (show GABRG2 Proteins)-RELN-PTCH1 (show PTCH1 Proteins) interaction networks might confer altered susceptibility to Hirschsprung disease.

  8. RELN is mapped at 7q22, which had been identified as a candidate region for autism by early genetic linkage study.

  9. reelin promotes multiple myeloma cell adhesion, survival, and drug resistance via activation of integrin alpha5beta1.

  10. These findings suggest that circulating Reelin promotes atherosclerosis by increasing vascular inflammation, and that reducing or inhibiting circulating Reelin may present a novel approach for the prevention of cardiovascular disease.

Pig (Porcine) Reelin (RELN) interaction partners

  1. A peak in Reelin mRNA and protein expression is present in the pig embryonic brain during the period of major neurogenesis and neuronal migration.

Reelin (RELN) Protein Profile

Protein Summary

This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined.

Alternative names and synonyms associated with Reelin (RELN)

  • reelin (RELN)
  • reelin (reln)
  • reelin (Reln)
  • reelin-like (RELN)
  • LIS2 protein
  • MGC172539 protein
  • PRO1598 protein
  • Reelen protein
  • reeler protein
  • RELN protein
  • Rl protein

Protein level used designations for Reelin Proteins (RELN)

reelin , reelin-like , extracellular matrix serine protease , reelin, extracellular

GENE ID SPECIES
100058621 Equus caballus
260303 Danio rerio
398547 Xenopus laevis
463635 Pan troglodytes
579060 Strongylocentrotus purpuratus
696372 Macaca mulatta
786373 Bos taurus
100013879 Monodelphis domestica
100049232 Oryzias latipes
100192371 Xenopus (Silurana) tropicalis
100403212 Callithrix jacchus
100480458 Ailuropoda melanoleuca
100552788 Anolis carolinensis
100593340 Nomascus leucogenys
19699 Mus musculus
5649 Homo sapiens
24718 Rattus norvegicus
427850 Gallus gallus
483273 Canis lupus familiaris
100127480 Sus scrofa
100723362 Cavia porcellus
281450 Bos taurus
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