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Homotypic fusion and vacuole protein sorting complex colocalizes and interacts with Syntaxin 17, suggesting their association is critical during tethering and fusion of autophagosomes with lysosomes.
Syntaxin17 is recruited to the outer membrane of autophagosomes to mediate fusion through its interactions with ubisnap (SNAP-29 (show SNAP29 Proteins)) and VAMP7 (show VAMP7 Proteins) in Drosophila melanogaster
A 4.6 kb duplication in Syntaxin 17, associated with the Grey phenotype in horses, does not only predispose to melanoma development, but that a copy number expansion of the duplication may be a driving force for melanoma development.
In transgenic zebrafish, a construct with 2 copies of a 4.6-kb intronic duplication is a strong enhancer in neural crest cells but a single copy is a weak enhancer. It contains 2 MITF (show MITF Proteins) binding sites.
Both STX17 and the neighboring NR4A3 (show NR4A3 Proteins) gene are overexpressed in melanomas from Gray horses.
Data suggest that accumulation of autophagosomes confers cytotoxicity in a number of cell types including neurons mimicking neurodegeneration; RNA interference of combinations of MTOR (show FRAP1 Proteins), VPS33A (show VPS33A Proteins), and STX17 lead to accumulation of autophagosomes and cytotoxicity. (MTOR (show FRAP1 Proteins) = mechanistic target of rapamycin (show FRAP1 Proteins) kinase; VPS33A (show VPS33A Proteins) = vacuolar protein sorting 33A (show VPS33A Proteins); STX17 = syntaxin 17)
Pacer recruits PI3KC3 and HOPS (show ALPL Proteins) complexes to the autophagosome for their site-specific activation by anchoring to the autophagosomal SNARE (show NAPA Proteins) Stx17.
This study demonstrates that the amount of syntaxin 17 decreased in Hepatitis C Virus replicating cells. In addition, syntaxin 17 is identified to be a novel factor controlling the release of HCV, and the relevance of autophagosome-lysosome fusion as a regulator of the amount of released viral particles is revealed.
the homotypic fusion and protein sorting-tethering complex promotes autophagosome-lysosome fusion through interaction with STX17
Study identifies syntaxin 17 (Stx17) as the autophagosomal SNARE (show NAPA Proteins) required for fusion with the endosome/lysosome.
The syntaxin 17 is essential for maintaining the architecture of ERGIC and Golgi.
Common variants in the STX17 gene region do not play a key role in the pathogenesis of human melanoma.
Syntaxin-17 can be traced to the last eukaryotic common ancestor, hinting that the removal of damaged mitochondrial content may represent one of the earliest vesicle transport routes in the cell.
Study identifies syntaxin 17 (Stx17) as the autophagosomal SNARE (show VTI1B Proteins) required for fusion with the endosome/lysosome.
Implicated in vesicle trafficking to lysosomes. Could be involved in processes related to cell division (By similarity).
, syntaxin 17