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Aurora A (show AURKA Proteins) and B kinases directly phosphorylate Lgl to promote its mitotic relocalization.
Regulation of Polo by Aurora B and Map205 is required for cytokinesis.
We propose that mutual inhibitions between Aurora B a (show CDK1 Proteins)nd Cyclin B regulate the duration of abscission and thereby the number of sister cells in each cyst.
Aurora B kinase activity is not required during contractile ring ingression, providing insight into the mechanism of cytokinesis.
Aurora B interacts with and requires the Cdc37 (show CDC37 Proteins)/Hsp90 (show HSP90 Proteins) complex for its stability.
INCENP (show INCENP Proteins) binds to the cohesion protector protein (show PRDX2 Proteins) MEI-S332, which is also an excellent in vitro substrate for Aurora B kinase.
The results of experiment indicated that specific knockdown of Aurora kinase B led to prostate carcinoma cells apoptosis and inhibited tumor growth.
decrease in Aurora B results in diminished binding of the chromokinesin Kif4A to chromosome arms.
Aurora B kinase interacts with and phosphorylates Sgo1 (show SGOL1 Proteins). Aurora B-mediated phosphorylation of Sgo1 (show SGOL1 Proteins) regulates the distribution of Sgo1 (show SGOL1 Proteins) between centromeres and chromosome arms.
AURKC (show AURKC Proteins) rs758099 TT and (CC + CT) genotypes were positively associated with increased intestinal type gastric cancer (GC)risk, but not with an increased diffuse type GC risk. Based on these results, we can conclude that AURKA (show AURKA Proteins) rs1047972 and AURKC (show AURKC Proteins) rs758099 polymorphisms could affect the risk of GC development.
Aurora-C (show AURKC Proteins) interactions with members of the Chromosome Passenger Complex (CPC), Survivin (show BIRC5 Proteins) and Inner Centromere Protein (INCENP (show INCENP Proteins)) in reference to known Aurora-B interactions to understand the functional significance of Aurora-C (show AURKC Proteins) overexpression in human cancer cells, is reported.
Aurora kinase (show AURKA Proteins) inhibitor danusertib negatively regulated AURKB/p70S6K (show RPS6KB1 Proteins)/RPL15 (show RPL15 Proteins) axis with the involvement of PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins), AMPK (show PRKAA1 Proteins), and p38 MAPK (show MAPK14 Proteins) signaling pathways, leading to the induction of apoptosis and autophagy in human leukemia cells.
The kinase activity of Aurora B on serine 31 of histone H3.3 (show H3F3A Proteins) was biochemically confirmed with nucleosomal substrates in vitro.
in addition to its role in checkpoint signaling, MAD2 (show MAD2L1 Proteins) ensures chromosome stability through the regulation of AURORA B.
Ska promotes Aurora B activity to limit its own microtubule and kinetochore association.
partial co-localization of AKT3 (show AKT3 Proteins) with AURKB was observed during anaphase. Overall, this study suggests that AKT3 (show AKT3 Proteins) could repress the antiproliferative effects of AURKi, with a novel activity particularly suppressing the aneuploidy induction.
Aurkb phosphorylates Oct4 (show POU5F1 Proteins)(S229) during G2/M phase, leading to the dissociation of Oct4 (show POU5F1 Proteins) from chromatin, whereas PP1 (show PPP1CC Proteins) binds Oct4 (show POU5F1 Proteins) and dephosphorylates Oct4 (show POU5F1 Proteins)(S229) during M/G1 transition, which resets Oct4 (show POU5F1 Proteins)-driven transcription for pluripotency and the cell cycle.
Overexpression of Aurora B (show AURKC Proteins) also results in a reduced DNA damage response and decreased levels of the p53 (show TP53 Proteins) target p21(Cip1 (show CDKN1A Proteins)) in vitro and in vivo.
Chromsome stability is on of the tumor-suppressive functions of ARF as well as regulation of Aurora B (show AURKC Proteins) expression in tumors.
Using this mutant we show for the first time that AURKC has functions that do not overlap with AURKB. These functions include regulating localized CPC activity and regulating chromosome alignment and K-MT attachments at metaphase of meiosis I (Met I).
reduced accumulation of Aurora B (show AURKC Proteins) at the inner centromere region in cells lacking Pds5B (show PDS5B Proteins) impairs its error correction function, promoting chromosome mis (show AMH Proteins)-segregation and aneuploidy
Aurora B (show AURKC Proteins) and Ring1B (show RNF2 Proteins) co-occupy active promoters in resting lymphocytes.
FBXL2 (show FBXL2 Proteins) mediates Aurora B (show AURKC Proteins) ubiquitination and degradation within the midbody, which is sufficient to induce mitotic arrest and apoptosis.
Inhibitions of Aurora B (show AURKC Proteins) and Cyclin-dependent kinase 1 (show CDK1 Proteins) activity in vertebrate cells also have opposite effects on the timing of abscission.
Aurora B (show AURKC Proteins) represses p21(Cip1 (show CDKN1A Proteins)), preventing delayed DNA replication, Cdk (show CDK4 Proteins) inhibition and premature mitotic exit.
Calmodulin protects Aurora B (show AURKC Proteins) on the midbody to regulate the fidelity of cytokinesis.
Alterations in PGRMC1 (show PGRMC1 Proteins) and/or AURKB localization account in part for the increased aneuploidy and low development competence of oocytes from ovaries with reduced antral follicle counts.
AURKB associated with metaphase chromosomes.
Aurora B kinase is essential for furrow induction and maturation in the zebrafish embryo.
This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene.
, aurora B
, aurora B kinase
, dAurora B
, aurora/IPL1-related kinase 2
, serine/threonine-protein kinase 12
, serine/threonine-protein kinase aurora-B
, aurora kinase B
, serine/threonine-protein kinase 12-like
, aurora 1
, aurora kinase B-Sv1
, aurora kinase B-Sv2
, aurora- and Ipl1-like midbody-associated protein 1
, aurora-related kinase 2
, protein phosphatase 1, regulatory subunit 48
, serine/threonine kinase 12
, serine/threonine-protein kinase 5
, aurora- and IPL1-like midbody-associated protein 1
, serine/threonine kinase 5
, Serine/threonine-protein kinase 12
, cellular island
, serine/threonine kinase a
, I-kappa-B kinase 2
, I-kappa-B-kinase beta
, inhibitor of kappaB kinase beta
, inhibitor of nuclear factor kappa B kinase beta subunit
, inhibitor of nuclear factor kappa-B kinase subunit beta
, nuclear factor NF-kappa-B inhibitor kinase beta