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This study demonstrate an unprecedented role for c-Cbl in microglia-mediated neuroinflammation involving PI3K/Akt (show AKT1 Proteins)/NF-kappaB (show NFKB1 Proteins) pathway.
These studies reveal a novel, cell-autonomous requirement of CBL and CBL-B in epithelial stem cell maintenance during organ development and remodeling through modulation of mTOR (show FRAP1 Proteins) signaling.
mutant CBL proteins effectively compete with the remaining wild type CBL-B and juxtapose tyrosine kinase (show TYRO3 Proteins)-binding domain-associated protein tyrosine kinases with proline-rich region-associated signaling proteins to hyper-activate signaling downstream of hematopoietic growth factor (show IL-3 Proteins) receptors
results demonstrate that c-Cbl mediates the ubiquitination/degradation of integrin beta1, which leads to COMP (show COMP Proteins) deficiency-induced dilated cardiomyopathy.
Gem (show GEM Proteins), a gene encoding a GTPase (show RACGAP1 Proteins) that is upregulated by Cbl(Q367P) , enhanced hematopoietic stem cell activity and induced myeloid cell proliferation. In addition, Evi1 (show MECOM Proteins), a gene encoding a transcription factor, was found to cooperate with Cbl(Q367P) and progress CMML to AML (show RUNX1 Proteins).
Fasudil, a clinically safe ROCK inhibitor, decreases disease burden in a Cbl/Cbl-b deficiency-driven murine model of myeloproliferative disorders.
Cbl down-regulation protects mice against high-fat diet-induced obesity and insulin (show INS Proteins) resistance.
Cbl-b and c-Cbl regulate the degradation of Osterix through the ubiquitin-proteasome pathway.
Overexpression of Smad7 (show SMAD7 Proteins) in human HaCaT keratinocyte cells and mouse skin tissues elevated EGF receptor (EGFR (show EGFR Proteins)) activity by impairing ligand-induced ubiquitination and degradation of activated receptor, which is induced by the E3 ubiquitin ligase (show MUL1 Proteins) c-Cbl.
Erbin (show ERBB2IP Proteins) promotes tumourigenesis and tumour growth in colorectal cancer by stabilizing epidermal growth factor receptor (show EGFR Proteins)
These results suggest MET overexpression is related to altered c-CBL expression in head and neck squamous cell carcinoma, which may influence tumorigenesis
This study identified a new regulatory axis in which miR (show MLXIP Proteins)-124-3p and CBL regulate the proliferation and invasion of breast cancer cells.
The viral entry receptor Nectin-1 (show PVRL1 Proteins) is also internalized during HSV-1 infection in a Cbl-dependent mechanism, and that increases the opportunity of the virus to spread to uninfected cells.
mutant CBL proteins effectively compete with the remaining wild type CBL-B and juxtapose tyrosine kinase (show TXK Proteins)-binding domain-associated protein tyrosine kinases with proline-rich region-associated signaling proteins to hyper-activate signaling downstream of hematopoietic growth factor (show IL-3 Proteins) receptors
we report that two JMML patients survived >20 years without HSCT and both patients had uniparental disomy of 11q23 where CBL is located without the phenomenon found in neither Noonan syndrome nor Noonan syndrome-like disorder. We think that some JMML patients with CBL mutation might show the good prognosis in later life after remission of JMML.
we found that CQ decreased the expression of Cbl, an E3 ligase of DR5 (show TNFRSF10B Proteins), and knock-down of Cbl markedly enhanced DR5 (show TNFRSF10B Proteins) up-regulation. Other lysosomal inhibitors, including monensin and nigericin, also up-regulated DR5 (show TNFRSF10B Proteins) and sensitized TRAIL-mediated apoptosis
miR (show MLXIP Proteins)-513a-5p, miR (show MLXIP Proteins)-22-3p and miR (show MLXIP Proteins)-625-5p may have an impact on the regulation of the immune response and inflammatory cytokine pathways through the regulation of their target gene(s), CBL, PPARGC1B and ESR1 (show ESR1 Proteins), which may then lead to a dust mite-induced asthma attack
Data suggest that the combination of peritumoral Cbl and EGFR (show EGFR Proteins) serves as a much stronger indicator to make an accurate prognosis, especially during early recurrence.
H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b.
The study reveals a role of CBL in restricting myeloid proliferation of human AML1 (show RUNX1 Proteins)-ETOinduced leukemia, and identifies UBASH3B (show STS1 Proteins) as a potential target for pharmaceutical intervention.
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder.
E3 ubiquitin-protein ligase CBL
, casitas B-lineage lymphoma proto-oncogene
, proto-oncogene c-CBL
, signal transduction protein CBL
, Cas-Br-M (murine) ecotropic retroviral transforming sequence
, RING finger protein 55
, fragile site, folic acid type, rare, fra(11)(q23.3)
, oncogene CBL2
, proto-oncogene c-Cbl
, Casitas B-lineage lymphoma