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Browse our CBL Proteins (CBL)

Full name:
Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence Proteins (CBL)
On are 6 Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) Proteins from 4 different suppliers available. Additionally we are shipping CBL Antibodies (266) and CBL Kits (12) and many more products for this protein. A total of 305 CBL products are currently listed.
4732447J05Rik, C-CBL, c-cbl-like, cbl, Cbl-2, CBL2, FRA11B, NSLL, RGD1561386, RNF55
list all proteins Gene Name GeneID UniProt
CBL 12402 P22682
CBL 867 P22681
Rat CBL CBL 500985  

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CBL Proteins (CBL) by Origin

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More Proteins for CBL Interaction Partners

Mouse (Murine) Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) interaction partners

  1. Gem (show GEM Proteins), a gene encoding a GTPase (show RACGAP1 Proteins) that is upregulated by Cbl(Q367P) , enhanced hematopoietic stem cell activity and induced myeloid cell proliferation. In addition, Evi1 (show MECOM Proteins), a gene encoding a transcription factor, was found to cooperate with Cbl(Q367P) and progress CMML to AML (show RUNX1 Proteins).

  2. Fasudil, a clinically safe ROCK inhibitor, decreases disease burden in a Cbl/Cbl-b deficiency-driven murine model of myeloproliferative disorders.

  3. Cbl down-regulation protects mice against high-fat diet-induced obesity and insulin (show INS Proteins) resistance.

  4. Cbl-b and c-Cbl regulate the degradation of Osterix through the ubiquitin-proteasome pathway.

  5. Overexpression of Smad7 (show SMAD7 Proteins) in human HaCaT keratinocyte cells and mouse skin tissues elevated EGF receptor (EGFR (show EGFR Proteins)) activity by impairing ligand-induced ubiquitination and degradation of activated receptor, which is induced by the E3 ubiquitin ligase (show MUL1 Proteins) c-Cbl.

  6. Erbin (show ERBB2IP Proteins) promotes tumourigenesis and tumour growth in colorectal cancer by stabilizing epidermal growth factor receptor (show EGFR Proteins)

  7. Whereas Cbl-PI3K interaction regulates differentiation and survival, bone resorption is predominantly regulated by Cbl-b in osteoclasts.

  8. c-Cbl activation promotes myocyte apoptosis, inhibits angiogenesis, and causes adverse cardiac remodeling after myocardial infarction.

  9. Data indicate a Cbl/p85 (show ECM1 Proteins)/epsin-1 (show EPN1 Proteins) pathway in erythropoietin receptor (EpoR (show EPOR Proteins)) endocytosis.

  10. These results support the notion that the distal cytoplasmic domain of CD5 (show CD5 Proteins), including Y463, plays a relevant role in the downmodulation of TCR signals in thymocytes via c-Cbl.

Human Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) interaction partners

  1. we report that two JMML patients survived >20 years without HSCT and both patients had uniparental disomy of 11q23 where CBL is located without the phenomenon found in neither Noonan syndrome nor Noonan syndrome-like disorder. We think that some JMML patients with CBL mutation might show the good prognosis in later life after remission of JMML.

  2. we found that CQ decreased the expression of Cbl, an E3 ligase of DR5 (show TNFRSF10B Proteins), and knock-down of Cbl markedly enhanced DR5 (show TNFRSF10B Proteins) up-regulation. Other lysosomal inhibitors, including monensin and nigericin, also up-regulated DR5 (show TNFRSF10B Proteins) and sensitized TRAIL-mediated apoptosis

  3. miR (show MLXIP Proteins)-513a-5p, miR (show MLXIP Proteins)-22-3p and miR (show MLXIP Proteins)-625-5p may have an impact on the regulation of the immune response and inflammatory cytokine pathways through the regulation of their target gene(s), CBL, PPARGC1B and ESR1 (show ESR1 Proteins), which may then lead to a dust mite-induced asthma attack

  4. Data suggest that the combination of peritumoral Cbl and EGFR (show EGFR Proteins) serves as a much stronger indicator to make an accurate prognosis, especially during early recurrence.

  5. H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b.

  6. The study reveals a role of CBL in restricting myeloid proliferation of human AML1 (show RUNX1 Proteins)-ETOinduced leukemia, and identifies UBASH3B (show STS1 Proteins) as a potential target for pharmaceutical intervention.

  7. By up-regulating the expression of c-Cbl and Cbl-b, which leads to inhibition of PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling and down-regulation of P-gp (show ABCB4 Proteins) expression, beta-elemene is capable of enhancing the efficacy of doxorubicin in leukemia and gastric cancer cells.

  8. Genotype-phenotype correlation analysis performed on available records indicated that germline CBL mutations cause a variable phenotype characterized by a relatively high frequency of neurological features, predisposition to diseases.

  9. The result indicated that TMZ may overcome TRAIL resistance in GSCs by suppressing c-FLIP (show CFLAR Proteins) expression through c-Cbl-mediated ubiquitination and degradation

  10. Demonstrate role for CBL in the control of AXL (show AXL Proteins)/SYK (show SYK Proteins)/LYN (show LYN Proteins) network mediating resistance to nilotinib treatment in chronic myeloid leukemia (show BCL11A Proteins) cells.

CBL Protein Profile

Protein Summary

This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder.

Alternative names and synonyms associated with CBL

  • Casitas B-lineage lymphoma (Cbl)
  • Cbl proto-oncogene, E3 ubiquitin protein ligase (CBL)
  • Cbl proto-oncogene, E3 ubiquitin protein ligase (Cbl)
  • 4732447J05Rik protein
  • C-CBL protein
  • c-cbl-like protein
  • cbl protein
  • Cbl-2 protein
  • CBL2 protein
  • FRA11B protein
  • NSLL protein
  • RGD1561386 protein
  • RNF55 protein

Protein level used designations for CBL

E3 ubiquitin-protein ligase CBL , casitas B-lineage lymphoma proto-oncogene , proto-oncogene c-CBL , signal transduction protein CBL , Cas-Br-M (murine) ecotropic retroviral transforming sequence , RING finger protein 55 , fragile site, folic acid type, rare, fra(11)(q23.3) , oncogene CBL2 , proto-oncogene c-Cbl , Casitas B-lineage lymphoma

12402 Mus musculus
867 Homo sapiens
489369 Canis lupus familiaris
100518854 Sus scrofa
527418 Bos taurus
500985 Rattus norvegicus
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