Browse our CD137 Proteins (TNFRSF9)

Full name:
Tumor Necrosis Factor Receptor Superfamily, Member 9 Proteins (TNFRSF9)
On are 62 Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) Proteins from 15 different suppliers available. Additionally we are shipping CD137 Antibodies (326) and CD137 Kits (28) and many more products for this protein. A total of 426 CD137 products are currently listed.
4-1BB, A930040I11Rik, AA408498, AI325004, Cd137, CDw137, ILA, Ly63, TNFRSF9, zgc:136557
list all proteins Gene Name GeneID UniProt
TNFRSF9 3604 Q07011
TNFRSF9 21942 P20334
TNFRSF9 708281  

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CD137 Proteins (TNFRSF9) by Origin

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Top referenced CD137 Proteins

  1. Human CD137 Protein expressed in Human Cells - ABIN2001947 : Ma, Mikolajczak, Danesh, Hosiawa, Cameron, Takaori-Kondo, Uchiyama, Kelvin, Ochi: The expression and the regulatory role of OX40 and 4-1BB heterodimer in activated human T cells. in Blood 2005 (PubMed)
    Show all 5 references for 2001947

  2. Human CD137 Protein expressed in Human Cells - ABIN2001949 : Alderson, Smith, Tough, Davis-Smith, Armitage, Falk, Roux, Baker, Sutherland, Din: Molecular and biological characterization of human 4-1BB and its ligand. in European journal of immunology 1994 (PubMed)
    Show all 4 references for 2001949

  3. Dog (Canine) CD137 Protein expressed in Human Cells - ABIN2008959 : Wen, Bukczynski, Watts: 4-1BB ligand-mediated costimulation of human T cells induces CD4 and CD8 T cell expansion, cytokine production, and the development of cytolytic effector function. in Journal of immunology (Baltimore, Md. : 1950) 2002 (PubMed)
    Show all 4 references for 2008959

  4. Dog (Canine) CD137 Protein expressed in Human Cells - ABIN2008961 : Saito, Ohara, Hotokezaka, Fukumoto, Yuasa, Naito, Fujiwara, Nakayama: Infection-induced up-regulation of the costimulatory molecule 4-1BB in osteoblastic cells and its inhibitory effect on M-CSF/RANKL-induced in vitro osteoclastogenesis. in The Journal of biological chemistry 2004 (PubMed)
    Show all 4 references for 2008961

  5. Human CD137 Protein expressed in Escherichia coli (E. coli) - ABIN1098269 : Langstein, Becke, Söllner, Krause, Brockhoff, Kreutz, Andreesen, Schwarz: Comparative analysis of CD137 and LPS effects on monocyte activation, survival, and proliferation. in Biochemical and biophysical research communications 2000 (PubMed)
    Show all 2 references for 1098269

  6. Human CD137 Protein expressed in HEK-293 Cells - ABIN2180545 : Jang, Lee, Kim, Kim, Kwon: Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B. in Biochemical and biophysical research communications 1998 (PubMed)

More Proteins for CD137 Interaction Partners

Human Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) interaction partners

  1. Egr2 (show EGR2 Proteins)-driven cell surface proteins LAG-3 (show LAG3 Proteins) and 4-1BB can identify dysfunctional tumor antigen-specific CD8 (show CD8A Proteins)(+) TIL (show TLR1 Proteins).

  2. Findings indicate that CD137 antigen is a useful marker that can be used for identifying Mycobacterium tuberculosis (Mtb (show NCAPG2 Proteins))-reactive CD4 (show CD4 Proteins)(+) T cells (Mtb (show NCAPG2 Proteins)-reactive CD4 (show CD4 Proteins)(+) T cells) by flow cytometry.

  3. Anti-4-1BB single chain variable fragments enhanced surface CD69 (show CD69 Proteins) expression and interleukin-2 (show IL2 Proteins) production in stimulated CCRF-CEM cells which confirmed the agonistic effect of the selected single chain variable fragments. The data from this study have provided a rationale for further experiments involving the biological functions of anti-4-1BB single chain variable fragments in future studies.

  4. Studies suggest that adoptive T cell therapy and CD137 antigen offer much opportunity to raise the efficacy of current cancer immunotherapies.

  5. Triple costimulation via CD80 (show CD80 Proteins), 4-1BB, and CD83 (show CD83 Proteins) ligand elicits the long-term growth of Vgamma9Vdelta2 T cells in low levels of IL-2 (show IL2 Proteins).

  6. These studies provide the first direct evidence that ligation of tumour necrosis factor (show TNF Proteins) superfamily members and their cognate receptors is important for the control of viral lytic replication.

  7. Our findings provide a novel, TNFRSF9-positive, reactive astrocytic phenotype in human gliomas

  8. Human genetic evidence for involvement of CD137 in atherosclerosis

  9. As a result of becoming activated, transferred human T lymphocytes express the inducible surface antigens hPD-1 (show PDCD1 Proteins) and hCD137 on their plasma membrane.

  10. Our results provide biological explanations for the antitumor effects of CD19 (show CD19 Proteins) CARs and for the observations that CD19 (show CD19 Proteins) CAR T cells incorporating the 4-1BB costimulatory domain are more persistent than those incorporating CD28 (show CD28 Proteins) in clinical trials.

Mouse (Murine) Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) interaction partners

  1. results indicate that one important diabetogenic function of CD137 is to promote the expansion and accumulation of beta cell-autoreactive CD8 (show CD8A Proteins) T cells, and in the absence of CD137 or its interaction with CD137 ligand, type 1 diabetes progression is suppressed

  2. High CD137 expression is associated with neoplasms.

  3. Ly6C, 4-1BB, and KLRG1 (show KLRG1 Proteins) have roles in the activation of lamina propria lymphocytes in the small intestine in a mouse model of Crohn's disease

  4. CD137 Regulates NFATc1 (show NFATC1 Proteins) Expression in Mouse VSMCs through TRAF6 (show TRAF6 Proteins)/NF-kappaB (show NFKB1 Proteins) p65 (show NFkBP65 Proteins) Signaling Pathway.

  5. 4-1BB triggering preferentially enhances the expansion of CD8 (show CD8A Proteins)+ T cells through the amplification of autocrine IL-2 (show IL2 Proteins)/IL-2R signaling loop.

  6. c-IAP (show ALPI Proteins) ubiquitin protein ligase (show UBE2K Proteins) activity is required for 4-1BB signaling and CD8 (show CD8A Proteins)(+) memory T-cell survival.

  7. we conclude that in vivo 4-1BB signaling of myeloid cells negatively regulates peripheral T cell responses

  8. activation of CD137 signaling decreases the stability of advanced atherosclerotic plaques via its combined effects on Teff cells, vascular smooth muscle cells, and macrophages

  9. 4-1BB mediates the inflammatory responses in obese skeletal muscle by interacting with its ligand 4-1BBL (show TNFSF9 Proteins) on macrophages.

  10. CD137-CD137L (show TNFSF9 Proteins) interactions mediated via regulation of CyPA (show PPIA Proteins) contribute to the progression of atherosclerosis.

CD137 (TNFRSF9) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.

Alternative names and synonyms associated with CD137 (TNFRSF9)

  • tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)
  • tumor necrosis factor receptor superfamily, member 9a (tnfrsf9a)
  • tumor necrosis factor receptor superfamily, member 9 (LOC100348914)
  • tumor necrosis factor receptor superfamily, member 9 (Tnfrsf9)
  • 4-1BB protein
  • A930040I11Rik protein
  • AA408498 protein
  • AI325004 protein
  • Cd137 protein
  • CDw137 protein
  • ILA protein
  • Ly63 protein
  • TNFRSF9 protein
  • zgc:136557 protein

Protein level used designations for TNFRSF9

tumor necrosis factor receptor superfamily, member 9 , tumor necrosis factor receptor superfamily member 9 , 4-1BB ligand receptor , CD137 antigen , T cell antigen ILA , T-cell antigen 4-1BB homolog , T-cell antigen ILA , homolog of mouse 4-1BB , induced by lymphocyte activation (ILA) , interleukin-activated receptor, homolog of mouse Ly63 , receptor protein 4-1BB , T-cell antigen 4-1BB , secreted CD137 antigen

419365 Gallus gallus
520341 Bos taurus
608274 Canis lupus familiaris
678622 Danio rerio
708281 Macaca mulatta
746029 Pan troglodytes
100196937 Papio anubis
100348914 Oryctolagus cuniculus
3604 Homo sapiens
21942 Mus musculus
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