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Human CD137 Protein expressed in Human Cells - ABIN2001947
Ma, Mikolajczak, Danesh, Hosiawa, Cameron, Takaori-Kondo, Uchiyama, Kelvin, Ochi: The expression and the regulatory role of OX40 and 4-1BB heterodimer in activated human T cells. in Blood 2005
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the role of CD137-CRDI (cysteine rich domain I) in the binding of CD137-CD137L (show TNFSF9 Proteins) was further investigated.
Egr2 (show EGR2 Proteins)-driven cell surface proteins LAG-3 (show LAG3 Proteins) and 4-1BB can identify dysfunctional tumor antigen-specific CD8 (show CD8A Proteins)(+) TIL (show TLR1 Proteins).
Findings indicate that CD137 antigen is a useful marker that can be used for identifying Mycobacterium tuberculosis (Mtb (show NCAPG2 Proteins))-reactive CD4 (show CD4 Proteins)(+) T cells (Mtb (show NCAPG2 Proteins)-reactive CD4 (show CD4 Proteins)(+) T cells) by flow cytometry.
Anti-4-1BB single chain variable fragments enhanced surface CD69 (show CD69 Proteins) expression and interleukin-2 (show IL2 Proteins) production in stimulated CCRF-CEM cells which confirmed the agonistic effect of the selected single chain variable fragments. The data from this study have provided a rationale for further experiments involving the biological functions of anti-4-1BB single chain variable fragments in future studies.
Studies suggest that adoptive T cell therapy and CD137 antigen offer much opportunity to raise the efficacy of current cancer immunotherapies.
Triple costimulation via CD80 (show CD80 Proteins), 4-1BB, and CD83 (show CD83 Proteins) ligand elicits the long-term growth of Vgamma9Vdelta2 T cells in low levels of IL-2 (show IL2 Proteins).
These studies provide the first direct evidence that ligation of tumour necrosis factor (show TNF Proteins) superfamily members and their cognate receptors is important for the control of viral lytic replication.
Our findings provide a novel, TNFRSF9-positive, reactive astrocytic phenotype in human gliomas
Human genetic evidence for involvement of CD137 in atherosclerosis
As a result of becoming activated, transferred human T lymphocytes express the inducible surface antigens hPD-1 (show PDCD1 Proteins) and hCD137 on their plasma membrane.
Data indicate that anti-CD137 agonists can function as inhibitors of CD137L (show TNFSF9 Proteins) signaling, resulting in the creation of tumor microenvironments unfavorable for tumor immune evasion.
These studies reveal that the costimulatory effects of TLR1 (show TLR1 Proteins)-TLR2 signaling in CD8 (show CD8A Proteins)(+) T cells are in part mediated by 4-1BB and are important for mounting an effective antitumor immune response.
This study discovers the 4-1BB pathway signaling enhances inflammatory response and promotes pulmonary fibrosis induced by crystalline silica.
Constitutive interaction between 4-1BB and 4-1BBL (show TNFSF9 Proteins) on murine LPS (show TLR4 Proteins)-activated bone marrow dendritic cells masks detection of 4-1BBL (show TNFSF9 Proteins) by TKS (show PTK6 Proteins)-1 but not 19H3 antibody.
results indicate that one important diabetogenic function of CD137 is to promote the expansion and accumulation of beta cell-autoreactive CD8 (show CD8A Proteins) T cells, and in the absence of CD137 or its interaction with CD137 ligand, type 1 diabetes progression is suppressed
High CD137 expression is associated with neoplasms.
Ly6C, 4-1BB, and KLRG1 (show KLRG1 Proteins) have roles in the activation of lamina propria lymphocytes in the small intestine in a mouse model of Crohn's disease
CD137 Regulates NFATc1 (show NFATC1 Proteins) Expression in Mouse VSMCs through TRAF6 (show TRAF6 Proteins)/NF-kappaB (show NFKB1 Proteins) p65 (show NFkBP65 Proteins) Signaling Pathway.
4-1BB triggering preferentially enhances the expansion of CD8 (show CD8A Proteins)+ T cells through the amplification of autocrine IL-2 (show IL2 Proteins)/IL-2R signaling loop.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
tumor necrosis factor receptor superfamily, member 9
, tumor necrosis factor receptor superfamily member 9
, 4-1BB ligand receptor
, CD137 antigen
, T cell antigen ILA
, T-cell antigen 4-1BB homolog
, T-cell antigen ILA
, homolog of mouse 4-1BB
, induced by lymphocyte activation (ILA)
, interleukin-activated receptor, homolog of mouse Ly63
, receptor protein 4-1BB
, T-cell antigen 4-1BB
, secreted CD137 antigen