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Deletion of CD28 co-stimulatory signals exacerbates left ventricular remodeling and increases cardiac rupture after MI through prolongation of the inflammatory period and reduction of collagen fiber in the infarct scars.
identified a new plasmacytoid dendritic cells regulatory mechanism by which the same CD28 molecule that promotes stimulation in most cells
Ndrg1 (show NDRG1 ELISA Kits) is phosphorylated and degraded by CD28 signalling in a proteasome-dependent manner.
The CD4/CD8 positive lymphocyte count and the expression of CD28 and CD38 antigens in the murine schistosomiasis japonica model are reported.
results suggest a key role for CD28 costimulation in promoting a central Treg to eTreg transition with appropriate upregulation of chemokine (show CCL1 ELISA Kits) receptors such as CCR6 (show CCR6 ELISA Kits) that are required for tissue homing
provide evidence that CD28 and the TCR complex regulate NF-kappaB (show NFKB1 ELISA Kits) via different signaling modules of GRB-2 (show GRB2 ELISA Kits)/VAV1 (show VAV1 ELISA Kits) and LAT (show LAT ELISA Kits)/ADAP (show APP ELISA Kits) pathways respectively.
CD28 can still stimulate T cell activation in the absence of its cytosolic domain.
CD3 (show CD3E ELISA Kits)/CD28-inducible MNSFbeta (show FAU ELISA Kits)-Bcl-G complex may be involved in the regulation of T cell function and survival.
Virus exposure results in reduced T-cell expression of CD28.
CD28 persistence is required for helper T cell polarization in response to infection.
Following phosphorylation of the tyrosine, the proteins growth factor receptor-bound protein 2 (Grb2 (show GRB2 ELISA Kits)), Grb2 (show GRB2 ELISA Kits)-related adaptor downstream of Shc (show SHC1 ELISA Kits) (Gads (show GRAP2 ELISA Kits)), and p85 subunit of phosphoinositide 3-kinase may bind to pYMNM (where pY is phosphotyrosine) via their Src (show SRC ELISA Kits) homology 2 (SH2) domains, leading to downstream signaling to distinct immune pathways. These three adaptor proteins bind to the same site on CD28 with variable affinity
CD28 family receptors are potential clinical indicators for the rapid monitoring of changes in T cell function during CHB treatment.
The eQTL mapping analysis revealed that the variations in CD28 and NFKB1 gene content might affect the abundance of transcripts of CD28 and Family with sequence similarity 177 member A1 (FAM177A1) genes, respectively. These results suggest that CD28 and NFKB1 gene variants may be associated with increased risks to IRM.
this study shows that CD28 contributes to rheumatoid arthritis susceptibility in Egyptian
A highly recurrent novel missense mutation in CD28 among angioimmunoblastic T-cell lymphoma patients.
Human mesenchymal stromal cells enhance the immunomodulatory function of CD8 (show CD8A ELISA Kits)(+)CD28(-) regulatory T cells.
These findings indicate that the associations of the CTLA-4 (show CTLA4 ELISA Kits) and CD28 polymorphisms with the risk of renal cancer are worth further study in a larger group of patients.
In patients presenting with acute coronary syndrome, the CD4 (show CD4 ELISA Kits) + CD28null T cell percentage was higher in patients with non-ST-segment-elevation acute coronary syndrome versus those with STEMI.
Data show that CD28 antigen costimulation modulates CD46 (show CD46 ELISA Kits) antigen surface expression on activated T cells.
study also uncovered a previously unappreciated role for Vav1 in crosstalk between the CD28 and TCR signaling pathways
The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, T-cell-specific surface glycoprotein CD28
, CD28 antigen (Tp44)
, T-cell-specific surface glycoprotein CD28 homolog
, T-cell costimulatory molecule CD28
, cell surface protein
, costimulatory molecule B7 receptor CD28
, antigen CD28
, T-cell specific surface glycoprotein CD28