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Deletion of CD28 co-stimulatory signals exacerbates left ventricular remodeling and increases cardiac rupture after MI through prolongation of the inflammatory period and reduction of collagen fiber in the infarct scars.
identified a new plasmacytoid dendritic cells regulatory mechanism by which the same CD28 molecule that promotes stimulation in most cells
Ndrg1 (show NDRG1 ELISA Kits) is phosphorylated and degraded by CD28 signalling in a proteasome-dependent manner.
The CD4/CD8 positive lymphocyte count and the expression of CD28 and CD38 antigens in the murine schistosomiasis japonica model are reported.
results suggest a key role for CD28 costimulation in promoting a central Treg to eTreg transition with appropriate upregulation of chemokine (show CCL1 ELISA Kits) receptors such as CCR6 (show CCR6 ELISA Kits) that are required for tissue homing
provide evidence that CD28 and the TCR complex regulate NF-kappaB (show NFKB1 ELISA Kits) via different signaling modules of GRB-2 (show GRB2 ELISA Kits)/VAV1 (show VAV1 ELISA Kits) and LAT (show LAT ELISA Kits)/ADAP (show APP ELISA Kits) pathways respectively.
CD28 can still stimulate T cell activation in the absence of its cytosolic domain.
CD3 (show CD3E ELISA Kits)/CD28-inducible MNSFbeta (show FAU ELISA Kits)-Bcl-G complex may be involved in the regulation of T cell function and survival.
Virus exposure results in reduced T-cell expression of CD28.
CD28 persistence is required for helper T cell polarization in response to infection.
A highly recurrent novel missense mutation in CD28 among angioimmunoblastic T-cell lymphoma patients.
Human mesenchymal stromal cells enhance the immunomodulatory function of CD8 (show CD8A ELISA Kits)(+)CD28(-) regulatory T cells.
These findings indicate that the associations of the CTLA-4 (show CTLA4 ELISA Kits) and CD28 polymorphisms with the risk of renal cancer are worth further study in a larger group of patients.
In patients presenting with acute coronary syndrome, the CD4 (show CD4 ELISA Kits) + CD28null T cell percentage was higher in patients with non-ST-segment-elevation acute coronary syndrome versus those with STEMI.
Data show that CD28 antigen costimulation modulates CD46 (show CD46 ELISA Kits) antigen surface expression on activated T cells.
study also uncovered a previously unappreciated role for Vav1 in crosstalk between the CD28 and TCR signaling pathways
Among CD8 (show CD8A ELISA Kits)+ T-lymphocytes, CD28+CD57 (show B3GAT1 ELISA Kits)+ cells represent a subset with some senescent features that are distinct from the CD28-CD57 (show B3GAT1 ELISA Kits)+ cells.
The CD28 gene polymorphisms may not only act in immune deregulation observed in schizophrenia, but may also influence the course of the illness by modifying the susceptibility to the co-occurrence of psychotic and affective symptoms
CD28 polymorphism, rs3116496, contributes to cancer susceptibility in the case of multiple cancers.
The functional decline of invariant natural killer T cells was closely related to the decrease in CD28 expression and the increases of Tim-3 (show HAVCR2 ELISA Kits) and PD-1 (show PDCD1 ELISA Kits).
The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, T-cell-specific surface glycoprotein CD28
, CD28 antigen (Tp44)
, T-cell-specific surface glycoprotein CD28 homolog
, T-cell costimulatory molecule CD28
, cell surface protein
, costimulatory molecule B7 receptor CD28
, antigen CD28
, T-cell specific surface glycoprotein CD28