Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species
The model showed agreement at several key nodes, involving scaffolding proteins Gab1, Gab2 and their complexes with Shp2 (show PTPN11 ELISA Kits). VEGFR2 (show KDR ELISA Kits) recruitment of Gab1 is greater in magnitude, slower, and more sustained than that of Gab2. As Gab2 binds VEGFR2 (show KDR ELISA Kits) complexes more transiently than Gab1, VEGFR2 (show KDR ELISA Kits) complexes can recycle and continue to participate in other signaling pathways.
The authors showed that GAB2 is cleaved at G238 during Coxsackievirus type B3 infection by viral proteinase 2A, generating two cleaved fragments of GAB2-N1-237 and GAB2-C238-676.
Studied BAK1 (show BAK1 ELISA Kits), SPRY4 (show SPRY4 ELISA Kits) and GAB2 SNPs in pediatric germ cell tumors(GCT (show QPCT ELISA Kits)); found a variant in SPRY4 (show SPRY4 ELISA Kits) was associated with reduced risk of GCT (show QPCT ELISA Kits); a variant in BAK1 (show BAK1 ELISA Kits) was positively associated with GCT (show QPCT ELISA Kits) with a strong estimated effect for testis tumors; and a SNP in GAB2 was associated with increased risk for GCT (show QPCT ELISA Kits).
overexpression of GAB2 in ovarian cancer cells promotes tumor growth and angiogenesis by upregulating expression of CXCL1 (show CXCL1 ELISA Kits), CXCL2 (show CXCL2 ELISA Kits) and CXCL8 (show IL8 ELISA Kits) that is IKKbeta (show IKBKB ELISA Kits)-dependent.
GAB2 is a key intermediary between YAP (show YAP1 ELISA Kits)/TAZ (show TAZ ELISA Kits) and the PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) pathway.
The findings of this study suggested that GAB2 rs2373115 may contribute to Alzheimer's disease susceptibility only in European population but not in East Asian population.
ERK1 (show MAPK3 ELISA Kits) and ERK2 (show MAPK1 ELISA Kits) interact with Gab2 via a novel docking motif, which is required for subsequent Gab2 phosphorylation in response to ERK1/2 (show MAPK1/3 ELISA Kits) activation.
GAB2 is a functional downstream target of miR (show MLXIP ELISA Kits)-302a in glioma. GAB2 role in cell proliferation, migration and invasion of glioma.
overexpression of GAB2 suppressed the expression of miR197 in glioblastoma cells.
GAB2 might promote hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)) cell proliferation by enhancing ERK (show EPHB2 ELISA Kits) signaling.
High Gab2 expression is associated with myeloproliferative neoplasm.
Gab2 may be a disease-associated protein that is induced by pathogenic factors to amplify and coordinate multifactor-induced signals to govern disease development in the liver.
Data, including data from studies in transgenic/knockout mice, suggest expression of Gab1/Gab2 is up-regulated in activated macrophages in pulmonary fibrosis; both Gab1/Gab2 are recruited to Il4r (show IL4R ELISA Kits), synergistically enhancing downstream signal amplification. (Gab1 = growth factor receptor bound protein 2-associated protein 1; Gab2 = growth factor receptor bound protein 2-associated protein 2; Il4r (show IL4R ELISA Kits) = interleukin-4 receptor (show IL4R ELISA Kits))
Given that GAB2 is dispensable for normal hematopoiesis, GAB2 and its effectors PI3K and SHP2 represent promising targets for therapy in Ph(+)hematologic neoplasms
Down-regulation of Gab2 has a protective function during M. tuberculosis infection, revealing a potential negative regulatory role for Gab2 in immunity to TB.
These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development
These results define a novel role for Gab2 in mediating mucin (show SLC13A2 ELISA Kits) gene expression and GCH (show GCH1 ELISA Kits); these findings have important implications for the pathogenesis and therapy of airway inflammatory diseases.
Our data provide genetic and biochemical evidence that CSF-1R, through Gab2, utilizes different effectors at different stages of MNP development to promote their expansion
Data indicate that fetal liver cells isolated from homozygous STAT5 (show STAT5A ELISA Kits) mutant mice lacking Gab2 showed significant reduction in HSC (show FUT1 ELISA Kits) number and survival.
The limited contribution of Fyn and Gab2 to the high affinity IgE receptor signaling in mast cells.
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
GRB2-associated binding protein 2
, GRB2-associated-binding protein 2
, Grb2-associated binder 2
, growth factor receptor bound protein 2-associated protein 2
, GRB2-associated binder 2
, Grb2 associated binder 2
, PH domain-containing adaptor molecule p97