Browse our GAB2 Proteins (GAB2)

On are 5 GRB2-Associated Binding Protein 2 (GAB2) Proteins from 4 different suppliers available. Additionally we are shipping GAB2 Antibodies (182) and GAB2 Kits (9) and many more products for this protein. A total of 202 GAB2 products are currently listed.
AI463667, D130058I17Rik, GAB2, p97
list all proteins Gene Name GeneID UniProt
GAB2 9846 Q9UQC2
GAB2 84477 Q9EQH1
GAB2 14389  

GAB2 Proteins (GAB2) by Origin

More Proteins for GAB2 Interaction Partners

Human GRB2-Associated Binding Protein 2 (GAB2) interaction partners

  1. The authors showed that GAB2 is cleaved at G238 during Coxsackievirus type B3 infection by viral proteinase 2A, generating two cleaved fragments of GAB2-N1-237 and GAB2-C238-676.

  2. Studied BAK1 (show BAK1 Proteins), SPRY4 (show SPRY4 Proteins) and GAB2 SNPs in pediatric germ cell tumors(GCT (show QPCT Proteins)); found a variant in SPRY4 (show SPRY4 Proteins) was associated with reduced risk of GCT (show QPCT Proteins); a variant in BAK1 (show BAK1 Proteins) was positively associated with GCT (show QPCT Proteins) with a strong estimated effect for testis tumors; and a SNP in GAB2 was associated with increased risk for GCT (show QPCT Proteins).

  3. overexpression of GAB2 in ovarian cancer cells promotes tumor growth and angiogenesis by upregulating expression of CXCL1 (show CXCL1 Proteins), CXCL2 (show CXCL2 Proteins) and CXCL8 (show IL8 Proteins) that is IKKbeta (show IKBKB Proteins)-dependent.

  4. GAB2 is a key intermediary between YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins) and the PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) pathway.

  5. The findings of this study suggested that GAB2 rs2373115 may contribute to Alzheimer's disease susceptibility only in European population but not in East Asian population.

  6. ERK1 and ERK2 interact with Gab2 via a novel docking motif, which is required for subsequent Gab2 phosphorylation in response to ERK1/2 activation.

  7. GAB2 is a functional downstream target of miR (show MLXIP Proteins)-302a in glioma. GAB2 role in cell proliferation, migration and invasion of glioma.

  8. overexpression of GAB2 suppressed the expression of miR197 in glioblastoma cells.

  9. GAB2 might promote hepatocellular carcinoma (HCC (show FAM126A Proteins)) cell proliferation by enhancing ERK (show EPHB2 Proteins) signaling.

  10. Data indicate that the most prominent proteins associating with Gab2 are PTPN11 (show PTPN11 Proteins), PIK3R1 and ARID3B (show ARID3B Proteins).

Mouse (Murine) GRB2-Associated Binding Protein 2 (GAB2) interaction partners

  1. Gab2 may be a disease-associated protein that is induced by pathogenic factors to amplify and coordinate multifactor-induced signals to govern disease development in the liver.

  2. Data, including data from studies in transgenic/knockout mice, suggest expression of Gab1/Gab2 is up-regulated in activated macrophages in pulmonary fibrosis; both Gab1/Gab2 are recruited to Il4r (show IL4R Proteins), synergistically enhancing downstream signal amplification. (Gab1 = growth factor receptor bound protein 2-associated protein 1; Gab2 = growth factor receptor bound protein 2-associated protein 2; Il4r (show IL4R Proteins) = interleukin-4 receptor (show IL4R Proteins))

  3. Given that GAB2 is dispensable for normal hematopoiesis, GAB2 and its effectors PI3K and SHP2 represent promising targets for therapy in Ph(+)hematologic neoplasms

  4. Down-regulation of Gab2 has a protective function during M. tuberculosis infection, revealing a potential negative regulatory role for Gab2 in immunity to TB.

  5. These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development

  6. These results define a novel role for Gab2 in mediating mucin (show SLC13A2 Proteins) gene expression and GCH (show GCH1 Proteins); these findings have important implications for the pathogenesis and therapy of airway inflammatory diseases.

  7. Our data provide genetic and biochemical evidence that CSF-1R, through Gab2, utilizes different effectors at different stages of MNP development to promote their expansion

  8. Data indicate that fetal liver cells isolated from homozygous STAT5 (show STAT5A Proteins) mutant mice lacking Gab2 showed significant reduction in HSC (show FUT1 Proteins) number and survival.

  9. The limited contribution of Fyn and Gab2 to the high affinity IgE receptor signaling in mast cells.

  10. comparative FISH mapping of Gab1 and Gab2 genes in human, mouse and rat

GAB2 Protein Profile

Protein Summary

This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.

Alternative names and synonyms associated with GAB2

  • GRB2-associated binding protein 2 (GAB2)
  • GRB2-associated binding protein 2 (LOC100349301)
  • GRB2-associated binding protein 2 (gab2)
  • GRB2-associated binding protein 2 (Gab2)
  • growth factor receptor bound protein 2-associated protein 2 (Gab2)
  • AI463667 protein
  • D130058I17Rik protein
  • GAB2 protein
  • p97 protein

Protein level used designations for GAB2

GRB2-associated binding protein 2 , GRB2-associated-binding protein 2 , Grb2-associated binder 2 , growth factor receptor bound protein 2-associated protein 2 , pp100 , GRB2-associated binder 2 , Grb2 associated binder 2 , PH domain-containing adaptor molecule p97

100062877 Equus caballus
748918 Pan troglodytes
100349301 Oryctolagus cuniculus
100566822 Anolis carolinensis
9846 Homo sapiens
485167 Canis lupus familiaris
84477 Rattus norvegicus
100513609 Sus scrofa
529346 Bos taurus
419027 Gallus gallus
14389 Mus musculus
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