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The findings of this study suggested that GAB2 rs2373115 may contribute to Alzheimer's disease susceptibility only in European population but not in East Asian population.
ERK1 and ERK2 interact with Gab2 via a novel docking motif, which is required for subsequent Gab2 phosphorylation in response to ERK1/2 activation.
GAB2 is a functional downstream target of miR (show MLXIP Proteins)-302a in glioma. GAB2 role in cell proliferation, migration and invasion of glioma.
overexpression of GAB2 suppressed the expression of miR197 in glioblastoma cells.
GAB2 might promote hepatocellular carcinoma (HCC (show FAM126A Proteins)) cell proliferation by enhancing ERK (show EPHB2 Proteins) signaling.
Data indicate that the most prominent proteins associating with Gab2 are PTPN11 (show PTPN11 Proteins), PIK3R1 and ARID3B (show ARID3B Proteins).
Study shows that Gab2 is significantly upregulated in metastasis-positive colorectal cancer (CRC (show CALR Proteins)) tissues and suggest that it plays a vital role in regulating CRC (show CALR Proteins) metastasis and a potential target for diagnosis.
Grb2-associated binder 2 silencing impairs growth and migration of non-small cell lung cancer cells via PI3K (show PIK3CA Proteins)-Akt (show AKT1 Proteins) signaling.
Gab2 may be involved in the onset and progression of HCC (show FAM126A Proteins), but its expression is unable to serve as an independent prognosis factor in HCC (show FAM126A Proteins) patients.
miR125a-5p acting as a novel Gab2 suppressor is partly down- regulated by DNA hypermethylation in glioma
Given that GAB2 is dispensable for normal hematopoiesis, GAB2 and its effectors PI3K and SHP2 represent promising targets for therapy in Ph(+)hematologic neoplasms
Down-regulation of Gab2 has a protective function during M. tuberculosis infection, revealing a potential negative regulatory role for Gab2 in immunity to TB.
These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development
These results define a novel role for Gab2 in mediating mucin (show SLC13A2 Proteins) gene expression and GCH (show GCH1 Proteins); these findings have important implications for the pathogenesis and therapy of airway inflammatory diseases.
Our data provide genetic and biochemical evidence that CSF-1R, through Gab2, utilizes different effectors at different stages of MNP development to promote their expansion
Data indicate that fetal liver cells isolated from homozygous STAT5 (show STAT5A Proteins) mutant mice lacking Gab2 showed significant reduction in HSC (show FUT1 Proteins) number and survival.
The limited contribution of Fyn and Gab2 to the high affinity IgE receptor signaling in mast cells.
comparative FISH mapping of Gab1 and Gab2 genes in human, mouse and rat
Transfected Gab2 is a limiting signaling component for Erk MAP kinase (show MAPK1 Proteins) activation and terminal differentiation of K562 CML cells.
Requirement of Gab2 for mast cell development and KitL/c-Kit signaling.
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
GRB2-associated binding protein 2
, GRB2-associated-binding protein 2
, Grb2-associated binder 2
, growth factor receptor bound protein 2-associated protein 2
, GRB2-associated binder 2
, Grb2 associated binder 2
, PH domain-containing adaptor molecule p97