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These data are consistent with a model in which bivalent recruitment of a GADS/SLP-76 (show LCP2 ELISA Kits) complex is required for costimulation by CD6 (show CD6 ELISA Kits).
Following phosphorylation of the tyrosine, the proteins growth factor receptor-bound protein 2 (Grb2 (show GRB2 ELISA Kits)), Grb2 (show GRB2 ELISA Kits)-related adaptor downstream of Shc (show SHC1 ELISA Kits) (Gads), and p85 subunit of phosphoinositide 3-kinase may bind to pYMNM (where pY is phosphotyrosine) via their Src (show SRC ELISA Kits) homology 2 (SH2) domains, leading to downstream signaling to distinct immune pathways. These three adaptor proteins bind to the same site on CD28 (show CD28 ELISA Kits) with variable affinity
GADS deficient T cells displayed similar levels of T cell receptor -induced SLP-76 (show LCP2 ELISA Kits) and PLC-gamma1 (show PLCG1 ELISA Kits) phosphorylation but exhibited substantial decrease in TCR-induced IL-2 (show IL2 ELISA Kits) and IFN-gamma (show IFNG ELISA Kits) release.
Gads was dispensable for TCR-induced phosphorylation of SLP-76 (show LCP2 ELISA Kits), but was a dose-dependent amplifier of TCR-induced CD69 (show CD69 ELISA Kits) expression.
GADS mediates lymphoid disease downstream of BCR-ABL (show ABL1 ELISA Kits) through the recruitment of specific signaling intermediates.
Histidine domain-protein tyrosine phosphatase (show ACP1 ELISA Kits) interacts with Grb2 (show GRB2 ELISA Kits) and GrpL
The results show that Bcr-Abl (show ABL1 ELISA Kits) regulates the actin cytoskeleton and non-apoptotic membrane blebbing via a GADS/Slp-76 (show LCP2 ELISA Kits)/Nck1 (show NCK1 ELISA Kits) adaptor protein pathway.
Exogenous expression of GrpL in a GrpL-negative B cell line leads to enhanced antigen receptor-induced extracellular signal-related kinase and p38 mitogen-activated protein kinase (show MAPK14 ELISA Kits) phosphorylation.
AML-1 (show RUNX1 ELISA Kits) plays a role in driving Mona (show MMP2 ELISA Kits) protein expression in T and myelomonocytic cells.
Plays a tissue-specific role as an inhibitor of RET receptor tyrosine kinase (show RET ELISA Kits) mitogenic signaling
High GADS expression is associated with neoplasms.
The combined loss of Gads and CD127 (show IL7R ELISA Kits) reveals a novel function of Gads prior to T cell receptor beta expression
Data show that the primary function of Gads is to regulate the sensitivity of the TCR to Ag ligation.
Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein (show GAB3 ELISA Kits) during monocyte/macrophage differentiation. (Gab3 scaffolding protein (show GAB3 ELISA Kits))
Results reveal the basis for preferential recognition of specific LAT (show LAT ELISA Kits) sites by Gads.
Mona/Gads SH3C binding to hematopoietic progenitor kinase 1 (HPK1) combines an atypical SH3 binding motif, R/KXXK, with a classical PXXP motif embedded in a polyproline type II (PPII) helix
The Gads adaptor protein is critical for homeostasis of CD4 (show CD4 ELISA Kits)(+) T cells.
Selective impairment of FcepsilonRI (show FCER1A ELISA Kits)-mediated allergic reaction in Gads-deficient mice
Gads plays a key role in linking the adapter LAT (show LAT ELISA Kits) to SLP-76 (show LCP2 ELISA Kits) in response to weak activation of GPVI (show GP6 ELISA Kits) and CLEC-2 (show CLEC1B ELISA Kits) whereas LAT (show LAT ELISA Kits) is required for full activation over a wider range of agonist concentrations.
This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Transcript variants utilizing alternative polyA sites exist.
GRB2-related adaptor protein 2
, GRB2-related adapter protein 2
, GRB-2-like protein
, GRB2-related protein with insert domain
, SH3-SH2-SH3 adapter Mona
, SH3-SH2-SH3 adaptor molecule
, adapter protein GRID
, grf40 adapter protein
, growth factor receptor-binding protein
, growth factor receptor-bound protein 2-related adaptor protein 2
, hematopoietic cell-associated adapter protein GrpL
, hematopoietic cell-associated adaptor protein GRPL
, GRB-2-related monocytic adapter protein
, Grb2-related adaptor downstream of Sch
, hematopoietic cell-associated adaptor protein GrpL
, monocytic adapter
, monocytic adaptor