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Data suggest that KH1 (show KCNF1 ELISA Kits) and HK2 (show HK2 ELISA Kits) domains of MEX3C (show MEX3C ELISA Kits) bind with high affinity to MRE10, a 10-mer (show MERTK ELISA Kits) RNA (5prime-CAGAGUUUAG-3prime) containing an eight-nucleotide MEX3C (show MEX3C ELISA Kits) recognition element motif (AGAGUUUA); 3prime-untranslated region of HLA-A2 mRNA contains such a high affinity binding site for KH domains of MEX3C (show MEX3C ELISA Kits). (MEX3C (show MEX3C ELISA Kits) = mex-3 RNA binding family member C; HLA-A2 = HLA class I (show MICA ELISA Kits) histocompatibility antigen, A-2 alpha chain (show FCGRT ELISA Kits))
this study shows that alpha3-deletion isoform of HLA-A11 plays role in the immune escape of HIV-1
Data suggest that personalized peptide vaccine (PPV (show PPP6C ELISA Kits)) with these nine CTL epitope peptides exhibit a good safety profile and positive immunological responses in HLA-A11+ or -A33 (show GPA33 ELISA Kits)+ cancer patients.
findings demonstrate that gliadins contain epitopes that elicit CD8 (show CD8A ELISA Kits)+ T cell responses restricted by HLA class I (show MICA ELISA Kits) A*0101 and B*0801 molecules
Data suggest that only a small fraction of HLA-A*02:01- (HA)-binding ESO peptides are immunogenic, namely those that have high peptide-binding strength and peptide/HA complex stability. This study involved comparison of in silico-predicted and observed cytotoxic T-lymphocyte recognition of tumor antigen epitopes in melanoma patients and transgenic/knockout mice. (ESO = tumor antigen NY-ESO-1 (show CTAG1B ELISA Kits))
The safety, the overall survival (OS), and the immunological responses based on an ELISPOT assay were determined to assess differences in patients who were HLA-A24 (show CD164 ELISA Kits)-positive [24(+)] and HLA-A24 (show CD164 ELISA Kits)-negative [24(-)].
Here we define the nature and extent of the variation in 3,489 HLA-A, 4,356 HLA-B and 3,111 HLA-C alleles. The common alleles of human populations comprise 42 core alleles, which represent all selected polymorphism, and recombinants that have assorted this polymorphism
It was shown that the HLA-A*34 allele is a risk factor for recurrent spontaneous abortion, while the HLA-A*24 and HLA-B*35 alleles are associated with protection, and no allele of the DRB1 locus was associated with recurrent spontaneous abortion
HLA-A alleles were not associated with predisposition to cutaneous leishmaniasis.
a significant level of epitope-specific T cells could be detected ex vivo in peripheral blood mononuclear cells from active TB patients by an HLA-A*11:01 dextramer carrying the peptide Rv3130c194-204.
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.
HLA class I histocompatibility antigen, A-1 alpha chain
, MHC class I antigen HLA-A heavy chain
, antigen presenting molecule
, leukocyte antigen class I-A