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Human LAT Protein expressed in Escherichia coli (E. coli) - ABIN667578
Paz, Wang, Clarke, Lu, Stokoe, Abo: Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells. in The Biochemical journal 2001
Show all 2 references for ABIN667578
Data indicate that the T cell-specific adaptor protein (TSAd (show SH2D2A Proteins)) SH2 domain interacts with CD6 antigen (show CD6 Proteins) and linker for activation of T cells protein (LAT (show ORC3 Proteins)) phosphotyrosine (pTyr) peptides.
High expression of LAT1 and ASCT2 (show SLC1A5 Proteins) correlates with metastasis and invasion in esophageal squamous cell carcinoma.
IFT20 (show IFT20 Proteins) is required for the delivery of the intracellular pool of LAT (show ORC3 Proteins) to the immune synapse in naive primary T lymphocytes.
Data show that the palmitoylation mutation of linker for activation of T cells (LAT)attenuated the signal transduction induced by glycosylphosphatidylinositol-anchored CD59 antigen (show CD59 Proteins) in T cells.
HSV-1-encoded Us3 protein interrupted TCR signaling and interleukin-2 (show IL2 Proteins) production by inactivation of the linker for activation of T cells.
Patients with severe aplastic anemia had increased levels of LAT (show ORC3 Proteins) and disturbed Th1 (show TH1L Proteins)-Th2 balance.
LAT (show ORC3 Proteins) is a modulator of CD3zeta (show CD247 Proteins) and ZAP-70 (show ZAP70 Proteins) tyrosine phosphorylation.
mutation of palmitoylation site of LAT (show ORC3 Proteins)-EGFP attenuated the signal transduction of CD59 (show CD59 Proteins) in T cells
findings show that L-type amino acid transporter 1 is a major transporter for essential amino acids into activated human T cells
Histone hypoacetylation on LAT (show ORC3 Proteins) promoter could inhibit LAT (show ORC3 Proteins) expression and enhanced Th2 differentiation, while trichostatin A, a histone deacetylase (show HDAC1 Proteins) inhibitor, promoted LAT (show ORC3 Proteins) expression and inhibited Th2 cytokine production
IFT20 (show IFT20 Proteins) is required for the delivery of the intracellular pool of LAT to the immune synapse in naive primary T lymphocytes.
miR (show MLXIP Proteins)-155 regulates the delicate balance between PAK1 (show PAK1 Proteins)-mediated proliferation and apoptosis in T cells impacting lymphoid organ size and function.
provide evidence that CD28 (show CD28 Proteins) and the TCR complex regulate NF-kappaB (show NFKB1 Proteins) via different signaling modules of GRB-2 (show GRB2 Proteins)/VAV1 (show VAV1 Proteins) and LAT/ADAP (show APP Proteins) pathways respectively.
The result indicate that LAT-PLCg1 (show PLCG1 Proteins) interaction is important for controlling IL-6 (show IL6 Proteins) production by T cells and demonstrate a critical role of IL-6 (show IL6 Proteins) in the development of the lymphoproliferative syndrome.
low level of LAT-PLC-gamma1 (show PLCG1 Proteins) interaction was associated with Th2 polarized differentiation, and this may contribute to the etiology of asthma.
These results suggest that proteasome-mediated degradation is involved in hypophosphorylated LAT and PLCgamma1 (show PLCG1 Proteins) in Dow2-induced anergic T cells. The novel CD3 (show CD3E Proteins)-specific Ab, Dow2, may provide us with a unique tool for inducing immunosuppression
Sos1 (show SOS1 Proteins) has distinct roles in acting as a scaffold to oligomerize the adaptor protein LAT, and in guanine nucleotide exchange activity
this analysis identified 65 proteins not associated before with the Zap70 (show ZAP70 Proteins)-Lat-SLP-76 (show LCP2 Proteins) network and thus should provide cues for future functional experiments.
Data suggest that transmembrane adaptor protein LAT-PLCgamma1 (Phospholipase C gamma 1 (show PLCG1 Proteins)) signaling may function differently in various subsets of gammadelta T cells.
chemotaxis toward antigen is controlled in mast cells by a cross-talk among FcepsilonRI (show FCER1A Proteins), tetraspanin CD9 (show CD9 Proteins), transmembrane adaptor proteins NTAL (show LAT2 Proteins) and LAT, and cytoskeleton-regulatory proteins of the ERM (show ETV5 Proteins) family
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.
linker for activation of T cells
, 36 kDa phospho-tyrosine adapter protein
, 36 kDa phospho-tyrosine adaptor protein
, linker for activation of T cells, transmembrane adaptor
, linker for activation of T-cells family member 1
, linker protein