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Browse our Mu Opioid Receptor 1 Proteins (OPRM1)

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Opioid Receptor, mu 1 Proteins (OPRM1)
On are 6 Opioid Receptor, mu 1 (OPRM1) Proteins from 3 different suppliers available. Additionally we are shipping Mu Opioid Receptor 1 Antibodies (111) and Mu Opioid Receptor 1 Kits (12) and many more products for this protein. A total of 140 Mu Opioid Receptor 1 products are currently listed.
6430411K18Rik, LMOR, M-OR-1, Mar, Mart1, MOP, MOP-R, mor, MOR-1, MOR-1O, MOR1, MORA, muOR, OPRM, OPRM1, Oprrm1, or2, Peg11, ZFOR2
list all proteins Gene Name GeneID UniProt
Rat OPRM1 OPRM1 81829 P04636
OPRM1 4988 P35372
OPRM1 18390 P42866

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Mu Opioid Receptor 1 Proteins (OPRM1) by Origin

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Top referenced Mu Opioid Receptor 1 Proteins

  1. Human Mu Opioid Receptor 1 Protein expressed in Wheat germ - ABIN1313419 : Perlikowska, Gach, Fichna, Toth, Walkowiak, do-Rego, Janecka: Biological activity of endomorphin and [Dmt1]endomorphin analogs with six-membered proline surrogates in position 2. in Bioorganic & medicinal chemistry 2009 (PubMed)

More Proteins for Mu Opioid Receptor 1 Interaction Partners

Zebrafish Opioid Receptor, mu 1 (OPRM1) interaction partners

  1. demonstrate that zfMOR exhibits a pharmacological profile similar to that of the mammalian MOR.

Human Opioid Receptor, mu 1 (OPRM1) interaction partners

  1. AA patients for opioid receptor mu 1 single nucleotide polymorphism had significantly lower cognitive function than AG patients.

  2. Study shows that overnight-abstinent smokers have decreased mu-opioid receptor (MOR) nondisplaceable binding potential (BPND) compared to nonsmoking controls, and that those individuals with the lowest MOR BPND in the basal ganglia also had higher nicotine dependence scores and greater craving after overnight nicotine abstinence; also suggests that A118G genotype may differentially affect MOR BPND in smokers vs. nonsmo...

  3. OPRM1 minor variant of A118G (G-allele) predicts greater speed-dating success for women.

  4. The OPRM1 G118 allele was significantly associated with more severe alcohol dependence in the Turkish population. Similar to other European populations, the frequency of the OPRM1 T17 allele was very low.

  5. We found a C-rich element (CRE) in mu-opioid receptor (MOR) 3'-untranslated region (UTR) to which poly (rC) binding protein 1 (PCBP1 (show PCBP1 Proteins)) binds, resulting in MOR mRNA stabilization. AUF1 (show HNRNPD Proteins) phosphorylation also led to an increased interaction with PCBP1 (show PCBP1 Proteins).

  6. rs1799971 of OPRM1 contributes to mechanisms of addiction liability that are shared across different addictive substances.

  7. Initial studies in neonates with in utero opiate exposure demonstrated that single-nucleotide polymorphisms in OPRM1 gene were associated with improved outcomes in infants with Neonatal abstinence syndrome.

  8. OPRM1 might be used in near future to customize the opioid therapy, avoiding not only opioid side effects

  9. The study successfully developed a population PKPD model for oxycodone across three experimental pain types and investigated the association between 18 SNPs across all three opioid receptor genes (OPRM1, OPRK1, OPRD1) and analgesic response from oxycodone. None of the selected polymorphisms were significantly associated with analgesic response of oxycodone.

  10. OPRM1 A118G genotype was associated with alcohol self administration and subjective measures of alcohol sensitivity.

Mouse (Murine) Opioid Receptor, mu 1 (OPRM1) interaction partners

  1. inhibition of mu-opioid receptor expression blocks morphine and DAMGO increases in the translocation of NF-kB p65 protein in microglia.a low dose of morphine, exerting its effects via the mu-opioid receptor, increases the DNA-binding activity of NF-kB via PKCepsilon, while a high dose of morphine triggers a nonopiate receptor response mediated by TLR4 and, interestingly, PKC signalling

  2. Paternally expressed 11/Retrotransposon-like 1 (Peg11/Rtl1) knockout (KO) mice show mid- to late fetal lethality or late fetal growth retardation associated with frequent neonatal lethality

  3. findings indicate that G9a (show EHMT2 Proteins) contributes critically to transcriptional repression of MORs in primary sensory neurons in neuropathic pain. G9a (show EHMT2 Proteins) inhibitors may be used to enhance the opioid analgesic effect in the treatment of chronic neuropathic pain.

  4. In addition to generating a series of prototypic seven transmembrane domain G protein-coupled receptors, Oprm1 produces a set of truncated splice variants containing only six transmembrane domains through which selected opioids mediate a potent analgesia.

  5. Morphine treatment interferes with neuronal differentiation via MOR activation.

  6. These investigations represent a reverse translational approach to investigating how the OPRM1 A118G polymorphism alters mesolimbic responses to opioids, which may elucidate mechanisms influencing both opioid and alcohol abuse in human populations

  7. Results suggested that the MOPR A118G SNP results in a loss of receptor function in the mouse hippocampus

  8. Study demonstrates a functional role for Mu Opioid Splice Variant MOR-1K in a murine model of opioid-induced hyperalgesia.

  9. In the colon, monoglyceride lipase (show MGLL Proteins) deficiency causes increased mu opioid receptor sensitivity.

  10. This study resolves distinct ligand-directed mechanisms of JNK activation by mu opioid agonists and understanding ligand-directed signaling at MOR may improve opioid therapeutics.

Cow (Bovine) Opioid Receptor, mu 1 (OPRM1) interaction partners

Rhesus Monkey Opioid Receptor, mu 1 (OPRM1) interaction partners

  1. Coactivation of mu opioid receptors with nociceptin receptors produces synergistic antinociception.

  2. Thisstudy adds to the growing literature showing that variation in the mu-opioid receptor gene OPRM1 is associated with social attachment and rejection.

  3. OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors.

  4. findings suggest a role for OPRM1 variation in the expression of attachment behavior, especially as a function of separation from the caregiver

Mu Opioid Receptor 1 (OPRM1) Protein Profile

Protein Summary

This gene encodes one of three opioid receptors. The mu opioid receptor is the principal target of endogenous opioid peptides and opioid analgesic agents such a s beta-endorphn and enkephalins. The NM_001008503.1:c.118A>G allele had been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Mu Opioid Receptor 1 (OPRM1)

  • opioid receptor, mu 1 (oprm1)
  • opioid receptor, mu 1 (OPRM1)
  • outer membrane efflux protein (oprM1)
  • outer membrane protein OprM (oprM1)
  • malate dehydrogenase 2, NAD (mitochondrial) (Mdh2)
  • opioid receptor, mu 1 (Oprm1)
  • retrotransposon-like 1 (Rtl1)
  • 6430411K18Rik protein
  • LMOR protein
  • M-OR-1 protein
  • Mar protein
  • Mart1 protein
  • MOP protein
  • MOP-R protein
  • mor protein
  • MOR-1 protein
  • MOR-1O protein
  • MOR1 protein
  • MORA protein
  • muOR protein
  • OPRM protein
  • OPRM1 protein
  • Oprrm1 protein
  • or2 protein
  • Peg11 protein
  • ZFOR2 protein

Protein level used designations for Opioid Receptor, mu 1 Proteins (OPRM1)

ZfMOR , mu-type opioid receptor , opioid receptor, mu 1 , mu-opioid receptor , outer membrane efflux protein , outer membrane protein OprM , malate dehydrogenase, mitochondrial , M-OR-1 , MOR-1 , MUOR1 , mu opioid receptor splice variant rMOR-1S , mu opioid receptor splice variant rMOR-1Z , opioid receptor B , micro opioid receptor isoform hMOR-1A2 , mu opiate receptor , mu opioid receptor hMOR-1a , MOP receptor , mu opioid receptor , mammalian retrotransposon derived protein 1 , paternally expressed gene 11 protein , retrotransposon-derived protein PEG11 , retrotransposon-like protein 1

65088 Danio rerio
484041 Canis lupus familiaris
100033967 Equus caballus
100585188 Nomascus leucogenys
4606278 Azoarcus sp. BH72
10918065 Cupriavidus necator N-1
81829 Rattus norvegicus
25601 Rattus norvegicus
4988 Homo sapiens
18390 Mus musculus
100379267 Cavia porcellus
396802 Sus scrofa
281958 Bos taurus
472165 Pan troglodytes
574141 Macaca mulatta
353326 Mus musculus
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