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anti-Rat (Meriones) PKC delta antibody for Western Blotting

Recommended PKC delta Antibody (supplied by: Log in to see )

Antigen
Protein Kinase C, delta (PKCd) Antibodies
  • AI385711
  • D14Ertd420e
  • fb09d10
  • fv43b11
  • MAY1
  • may1
  • npkc-delta
  • nPKC-delta
  • Pkaca
  • PKC-delta
  • pkc-delta2
  • pkcd
  • Pkcd
  • PKCD
  • PKCdelta
  • PKC[d]
  • prkcd
  • PRKCD
  • tpa-1
  • wu:fb09d10
  • wu:fv43b11
  • zgc:56558
Reactivity
Human, Mouse (Murine), Rat (Meriones)
256
144
125
7
2
2
2
2
2
Host
Rabbit
266
19
Clonality
Polyclonal
Conjugate
This PKC delta antibody is un-conjugated
9
9
7
4
4
4
3
3
3
3
3
3
3
3
3
Application
Western Blotting (WB)
225
128
104
36
35
27
11
10
6
2
1
1
1
1
1
1
Supplier
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Catalog No. ABIN2802039
$ 324.50
Plus shipping costs $45.00

Top referenced anti-PKC delta antibody for Western Blotting

Similar anti-PKC delta Antibodies

Application / Reactivity Human Mouse (Murine) Rat (Meriones)
Western Blotting (WB) 204 Antibodies 105 Antibodies 1 Antibodies
RNA Interference (RNAi) 1 Antibodies
Radioimmunoassay (RIA) 1 Antibodies
Proximity Ligation Assay (PLA) 1 Antibodies
Immunoprecipitation (IP) 11 Antibodies 5 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 35 Antibodies 20 Antibodies
Immunohistochemistry (IHC) 105 Antibodies 46 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 3 Antibodies 2 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 35 Antibodies 34 Antibodies
Immunofluorescence (IF) 27 Antibodies 19 Antibodies
Immunocytochemistry (ICC) 9 Antibodies 4 Antibodies

General

Antigen Protein Kinase C, delta (PKCd) Antibodies
Reactivity Human, Mouse (Murine), Rat (Meriones)
(256), (144), (125), (7), (2), (2), (2), (2), (2)
Host Rabbit
(266), (19)
Clonality
Polyclonal
Conjugate This PKC delta antibody is un-conjugated
(9), (9), (7), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application Western Blotting (WB)
(225), (128), (104), (36), (35), (27), (11), (10), (6), (2), (1), (1), (1), (1), (1), (1)
Pubmed 3 references available
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Product Details anti-PKC delta Antibody

Target Details PKC delta Application Details Handling References for anti-PKC delta Antibody (ABIN2802039) Images
Isotype IgG

Target Details PKC delta

Product Details anti-PKC delta Antibody Application Details Handling References for anti-PKC delta Antibody (ABIN2802039) Images back to top
Antigen
Alternative Name PKCD (PKCd Antibody Abstract)
Background Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor- initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53. In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)- induced inhibition of cell cycle progression at G1/S phase by up- regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation. Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1. Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro- survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl- phenylalanine (fMLP)-treated cells, is required for NCF1 (p47- phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways. May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA. In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation. Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion, acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release. Phosphorylates MUC1 in the C- terminal and regulates the interaction between MUC1 and beta- catenin. The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity).
Synonyms: Protein kinase C delta type, Tyrosine-protein kinase PRKCD, nPKC-delta, Protein kinase C delta type regulatory subunit, Protein kinase C delta type catalytic subunit, Sphingosine-dependent protein kinase-1, SDK1, PRKCD
Molecular Weight 77505 Da
Gene ID 5580
UniProt Q05655
Pathways TCR Signaling, Interferon-gamma Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-PKC delta Antibody Target Details PKC delta Handling References for anti-PKC delta Antibody (ABIN2802039) Images back to top
Application Notes WB - 1:250-1:1000
Restrictions For Research Use only

Handling

Product Details anti-PKC delta Antibody Target Details PKC delta Application Details References for anti-PKC delta Antibody (ABIN2802039) Images back to top
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

References for anti-PKC delta Antibody (ABIN2802039)

Product Details anti-PKC delta Antibody Target Details PKC delta Application Details Handling Images back to top
Background publications

Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003

Product cited in:

Nomoto, Watanabe, Ninomiya-Tsuji, Yang, Nagai, Kiuchi, Hagiwara, Hidaka, Matsumoto, Irie: "Functional analyses of mammalian protein kinase C isozymes in budding yeast and mammalian fibroblasts." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 2, Issue 10, pp. 601-14, 1998

Aris, Basta, Holmes, Ballas, Moomaw, Rankl, Blobel, Loomis, Burns: "Molecular and biochemical characterization of a recombinant human PKC-delta family member." in: Biochimica et biophysica acta, Vol. 1174, Issue 2, pp. 171-81, 1993

Images

Product Details anti-PKC delta Antibody Target Details PKC delta Application Details Handling References for anti-PKC delta Antibody (ABIN2802039) back to top
Supplier Images
Western Blotting (WB) image for anti-PKC delta antibody (Protein Kinase C, delta) (ABIN2802039) anti-Protein Kinase C, delta (PKCd) antibody