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PKCdelta is a critical regulator of signaling mechanisms of neutrophil-endothelium interaction in acute inflammation. Inhibition of PKCdelta in human endothelial cells and neutrophils reduced chemoattractant-induced neutrophil migration across TNF-alpha (show TNF ELISA Kits)-activated endothelium, and reduced expression of E-selectin (show SELE ELISA Kits) and ICAM-1 (show ICAM1 ELISA Kits). Shear rate and vascular geometry regulate the impact of PKCdelta inhibition of neutrophil-endot...
Lysophosphatidylcholines prime polymorphonuclear neutrophil through Hck (show HCK ELISA Kits)-dependent activation of PKCdelta, which stimulates PKCgamma (show PRKCG ELISA Kits), resulting in translocation of phosphorylated p47(phox).
The interplay between intracellular progesterone receptor (show PGR ELISA Kits) and PRKCA (show PKCa ELISA Kits)-PRKCD plays a key role in migration and invasion of human glioblastoma cells.
Amphiregulin (show AREG ELISA Kits) enhances VEGF-A (show VEGFA ELISA Kits) production in human chondrosarcoma cells and promotes angiogenesis by inhibiting miR (show MLXIP ELISA Kits)-206 via FAK (show PTK2 ELISA Kits)/c-Src (show SRC ELISA Kits)/PKCdelta pathway.
In the present investigation, we demonstrated that miR486 is negatively associated with the expression of PKC-delta and could regulate the development of osteosarcoma. miR (show MLXIP ELISA Kits)-486 may be a potential target for the treatment of osteosarcoma
PKCdelta and PKCepsilon (show PRKCE ELISA Kits) work as a functional couple with opposite roles on thrombopoiesis, and the modulation of their balance strongly impacts platelet production.
These findings suggest that targeting Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) or Akt (show AKT1 ELISA Kits) pathways may increase the efficacy of taxane chemotherapy in advanced human prostate cancers that have lost PKCdelta expression.
description of a rare monogenic form of juvenile systemic lupus erythematosus caused by a novel but damaging homozygous mutation affecting the active region of PRKCD.
MALAT1 recruits splice factor serine-arginine-rich splice factor 2 (SRSF2 (show SRSF2 ELISA Kits)) to promote alternative splicing of PKCdeltaII.
mechanistic studies, inhibition of SRC (show SRC ELISA Kits) and PKCdelta completely ablated the ability of MDA-7/IL-24 (show IL24 ELISA Kits) to reduce the Bcl-x(L (show BCL2L1 ELISA Kits))/(s) mRNA ratio and cell viability. These findings show that Bcl-x (show BCL2L1 ELISA Kits)(s) expression is an important mediator of MDA-7/IL-24 (show IL24 ELISA Kits)-induced cytotoxicity requiring the SRC (show SRC ELISA Kits)/PKCdelta signaling axis in NSCLC cells.
Data show that laminin alpha2beta1gamma1 (Lm211) can inhibit neuregulin 1 (show NRG1 ELISA Kits) type III (Nrg1III) by limiting protein kinase A (PKA) activation, which is required to initiate myelination.
spinal PKCdelta has a role in the development of chronic pain in SCD (show SCD ELISA Kits), which may become a potential target for pharmacological interventions
study identifies a new role of Dual-AKAP1 in regulating mitochondrial trafficking through Miro-2, and supports a model in which PINK1 and mitochondrial PKA participate in a similar neuroprotective signaling pathway to maintain dendrite connectivity
Data suggest that enzyme activation by cAMP involves highly stable conformation of Prkar1a as it binds to Prkaca; glycine residue, G235, appears to function as hinge in B/C helix conserved in Prkar1a; this "Flipback" conformation plays role in cAMP association to A domain of Prkar1a. (Prkar1a = cyclic AMP-dependent protein kinase RIalpha subunit; Prkaca = cyclic AMP-dependent protein kinase catalytic subunit)
K8/K18 (show KRT18 ELISA Kits)-dependent PKCdelta- and ASMase (show SMPD1 ELISA Kits)-mediated modulation of lipid raft size can explain the more prominent FasR-mediated signaling resulting from K8/K18 (show KRT18 ELISA Kits) loss.
cAMP dependent protein kinase A (PKA) is a key intracellular factor mediating SHH (show SHH ELISA Kits) signaling through regulation of GLI3 (show GLI3 ELISA Kits) processing.
this study shows illustrates for the first time the ability of protein kinase A to increase colony-stimulating factor 1 receptor (show CSF1R ELISA Kits) DNA methylation (show HELLS ELISA Kits) resulting in macrophage maturation
these results suggest that the activation of 5-HT1D receptors selectively enhanced IA via the Gbetagamma of the Go-protein, PKA, and the sequential B-Raf (show SNRPE ELISA Kits)-dependent p38 MAPK (show MAPK14 ELISA Kits) signaling cascade.
SphK1 (show SPHK1 ELISA Kits) dependent PKC-delta activation plays an important role in promoting NF-kappaB (show NFKB1 ELISA Kits) activation and inflammatory response in acute liver failure, and inhibition of PKC-delta activation might be a potential therapeutic strategy for this disease.
Report PRKCD-dependent regulation of bovine embryonic development, gene expression and post-hatching events.
investigation of signaling mechanism used by fibroblast growth factor-2 (FGF2 (show FGF2 ELISA Kits)) to regulate interferon-tau (IFNT) production in trophoblasts: several lines of evidence suggest that FGF2 (show FGF2 ELISA Kits) regulates IFNT production in trophoblasts by acting through PRKCD
deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS (show NOS3 ELISA Kits) post-translational modification
stimulation of bovine theca cells with lysophosphatidic acid leads to redistribution of protein kinase C delta from the cytosol to the perinuclear area and in the presence of LH, complete nuclear translocation of protein kinase C delta is induced
Protein kinase (show CDK7 ELISA Kits) Cdelta-dependent phosphorylation of syndecan-4 (show SDC4 ELISA Kits) regulates cell migration.
Activation of PKC (show PKC ELISA Kits) induces the translocation of Nrf2 (show NFE2L2 ELISA Kits) and the enhancement of endogenous antioxidant defenses in ischemic preconditioned rabbit heart.
PKC-delta (show PRKCG ELISA Kits) mediates the apoptotic processes through ROS (show ROS1 ELISA Kits)-dependent caspase-3 (show CASP3 ELISA Kits) activation
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed.
protein kinase C delta type
, protein kinase-delta2
, protein kinase C, delta
, protein kinase C delta type-like
, protein kinase C delta VIII
, tyrosine-protein kinase PRKCD
, protein kinase C delta variant IX
, protein kinase C, delta IV
, protein kinase C, delta V
, protein kinase C[d]
, protein kinase C delta
, PKA C-alpha
, cAMP-dependent protein kinase catalytic subunit alpha
, sperm cAMP-dependent protein kinase catalytic subunit