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The results indicate that PKC (show FYN ELISA Kits) could be the final target and an integrator molecule of different signaling pathways triggered by angiotensin II (Ang II), which could explain the sustained activation of Na(+)-ATPase (show DNAH8 ELISA Kits) by Ang II (show AGT ELISA Kits).
Phorbol 12-myristate 13-acetate activation of ERK (show MAPK1 ELISA Kits) and JNK (show MAPK8 ELISA Kits) signaling is relevant in the regulation of gene expression during follicular development, ovulation, and luteinization.
PKC-theta; is a critical factor for type 2 innate lymphoid cells activation that contributes to TH2 cell differentiation, which is associated with IRF4 (show IRF4 ELISA Kits) and NFAT1 (show NFAT1 ELISA Kits) expression in allergic lung inflammation.
Enhanced PRKCQ/PKCtheta; expression can promote growth-factor-independent growth, anoikis resistance, and migration. PRKCQ critically regulates growth and survival of a subset of TNBC.
Data suggest that, in T-lymphocytes, nitric oxide generated by eNOS (show NOS3 ELISA Kits) S-nitrosylates Cys374 on ACTB (show ACTB ELISA Kits) and thus regulates activation/recruitment of PRKCQ at immune synapse; S-nitrosylation of beta-actin (show ACTB ELISA Kits) impairs actin binding to PFN1 (show PFN1 ELISA Kits) and regulates protein transport in lamellipodia. (eNOS (show NOS3 ELISA Kits) = nitric oxide synthase (show NOS ELISA Kits) 3; ACTB (show ACTB ELISA Kits) = beta-actin (show ACTB ELISA Kits); PRKCQ = protein kinase C-theta; PFN1 (show PFN1 ELISA Kits) = profilin-1 (show PFN1 ELISA Kits))
PKCtheta;-induced phosphorylations control the ability of Fra-1 (show FOSL1 ELISA Kits) to stimulate gene expression and breast cancer cell migration.
Within the nucleus, PKC-theta; catalytic activity maintains the Ser536 phosphorylation on the p65 subunit of NF-kappaB (also known as RelA) and can directly influence chromatin accessibility at transcriptional memory genes by regulating H2B deposition.
Data show that tonantzitlolone (TZL) was able to induce protein kinase c theta (PKCtheta;)-dependent heat shock transcription factor 1 (HSF1 (show HSF1 ELISA Kits))phosphorylation.
The PRKCQ polymorphism is not associated with Behcet's Disease.
Sumoylation of PKC-theta; was essential for T cell activation. Desumoylation did not affect the catalytic activity of PKC-theta; but inhibited the association of CD28 (show CD28 ELISA Kits) with PKC-theta; and filamin A (show FLNA ELISA Kits) and impaired the assembly of a mature immunological synapse.
Together, these findings both in Jurkat T cells as well as in primary T cells indicate a regulatory role of Coro1A (show CORO1A ELISA Kits) on PKCtheta; recruitment and function downstream of the TCR leading to NF-kappaB (show NFKB1 ELISA Kits) transactivation.
PKCtheta; acts through the activation of p38 MAPK (show MAPK14 ELISA Kits) and autophagy induction. PKCtheta; acts through the activation of p38 MAPK (show MAPK14 ELISA Kits) and autophagy induction to induce the Epstein-Barr virus (EBV) lytic cycle.
Results suggest that while PKCtheta; is involved in Treg cell differentiation in vivo, it is dispensable for Treg-mediated suppression.
Data show that pharmacological inhibition of Protein Kinase C theta (PKCtheta;) in Duchenne Muscular Dystrophy (DMD (show DMD ELISA Kits)) can be considered an attractive strategy to modulate immune response and prevent the progression of the disease.
Knockdown of PKCtheta suppresses phosphorylation of IKK (show CHUK ELISA Kits) and JNK (show MAPK8 ELISA Kits) and consequently attenuates the HOCl-impaired insulin (show INS ELISA Kits) signaling pathway.
Data indicate that Protein kinase C theta; (PKCtheta;) is critical for stabilizing Th17 cell phenotype.
Data suggest that protein kinase (show CDK7 ELISA Kits) Ctheta (PKCtheta;) inhibition alone is insufficient for complete efficacy in rodent arthritis model.
Inhibition of PKC-theta preserves cardiac function and reduces fibrosis in streptozotocin-induced diabetic cardiomyopathy
DTX1, similar to Cbl-b and Itch, participates in T cell anergy-induced PKC-theta degradation. there is a coupling of DTX1 to Cbl-b in T cell anergy.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.
protein kinase C theta type
, PKC theta