Browse our RELA Proteins (RELA)

Full name:
V-Rel Reticuloendotheliosis Viral Oncogene Homolog A (Avian) Proteins (RELA)
On are 1 V-Rel Reticuloendotheliosis Viral Oncogene Homolog A (Avian) (RELA) Proteins from 1 different suppliers available. A total of 1 RELA products are currently listed.
NFKB3, p65
list all proteins Gene Name GeneID UniProt
RELA 5970 Q04206

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Human V-Rel Reticuloendotheliosis Viral Oncogene Homolog A (Avian) (RELA) interaction partners

  1. Whole-exome sequencing (WES) of the unaffected father and patients P1-P4 revealed seven rare NF-kappaB (show NFKB1 Proteins) subunit RelA (RELA (show NFkBP65 Proteins)) heterozygous variants shared by the patients and absent in the healthy father.

  2. miR (show MLXIP Proteins)-124 controls NF-kappaB (show NFKB1 Proteins)-dependent inflammatory responses in keratinocytes and chronic skin inflammation in atopic eczema; rescuing miR (show MLXIP Proteins)-124 expression presents a promising strategy for atopic eczema treatment.

  3. Data suggest that only the Fe(III) form of pirin (show PIR Proteins) [not the Fe(II) form] enhances affinity of binding between p65 (show GORASP1 Proteins) and DNA in the pirin (show PIR Proteins)-p65 (show GORASP1 Proteins)-DNA supramolecular complex. (pirin (show PIR Proteins) = quercetin 2,3-dioxygenase; p65 (show GORASP1 Proteins) = RELA (show NFkBP65 Proteins) proto-oncogene (show RAB1A Proteins) NF-kappaB (show NFKB1 Proteins) subunit)

  4. p21 (show CDKN1A Proteins) adjusts the equilibrium between p65 (show GORASP1 Proteins)-p50 (show CD40 Proteins) and p50-p50 NF-kappaB (show NFKB1 Proteins) pathways to mediate macrophage plasticity in LPS (show IRF6 Proteins) tolerance

  5. knockdown of RPA2 (show RPA2 Proteins) promoted formation of the menin-p65 (show GORASP1 Proteins) complex and repressed the expression of NF-kappaB (show NFKB1 Proteins)-mediated genes. RPA2 (show RPA2 Proteins) expression was induced via an E2F1 (show E2F1 Proteins)-dependent mechanism in MCF7 and MDA-MB-231 cells treated with NF-kappaB (show NFKB1 Proteins) activators, TNF-alpha (show TNF Proteins) or lipopolysaccharide (LPS (show IRF6 Proteins)).

  6. Consistent with these effects, RelA (show NFkBP65 Proteins) T505A mice exhibit earlier onset of cancer in the N-nitrosodiethylamine model of hepatocellular carcinoma. These data reveal a critical pathway controlling NF-kappaB (show NFKB1 Proteins) function in the liver that acts to suppress the tumour-promoting activities of RelA (show NFkBP65 Proteins).

  7. NF-kappaB (show NFKB1 Proteins) RelB (show RELB Proteins) protein, but not RelA (show NFkBP65 Proteins), displayed high expression in Endometrial cancer samples and cell lines.

  8. This study demonstrates for the first time that a prominent pathway of reovirus oncolysis of breast cancer is mediated through NF-kB p65 and that PUMA (show BBC3 Proteins) upregulation is dependent on NF-kB p65 activation.

  9. Site-differential phosphorylation of RelA/p65 (show NFkBP65 Proteins) modulates RITA (show ZNF331 Proteins) sensitivity in cancer cells.

  10. Vaccinia virus K1 inhibited acetylation of the RelA (p65 (show NFkBP65 Proteins)) subunit of NF-kappaB (show NFKB1 Proteins), a nuclear event known to be required for NF-kappaB (show NFKB1 Proteins) activation.

Cow (Bovine) V-Rel Reticuloendotheliosis Viral Oncogene Homolog A (Avian) (RELA) interaction partners

  1. Hepatic SREBP-1c (show SREBF1 Proteins)-mediated lipid synthesis and the NF-kappaB (show NFKB1 Proteins) inflammatory pathway were both overinduced in cows with fatty liver.

  2. Cytopathic bovine viral diarrhea virus strain induces immune marker production in bovine cells through the NF-kappaB (show NFKB1 Proteins) signaling pathway.

  3. The role of NF-kappaB (show NFKB1 Proteins) and C/EBP (show CEBPA Proteins) factors in regulating basal and pathogen-induced expression of both genes from cattle, is investigated.

  4. Altering the extracellular matrix to promote p38 (show MAPK14 Proteins) activation in cells on fibronectin (show FN1 Proteins) suppresses NF-kappaB (show NFKB1 Proteins) activation, suggesting a novel therapeutic strategy for treating

  5. full length coding sequence of the cattle transcription factor p65 (show NFkBP65 Proteins) was isolated and cloned

  6. the pathogen causing subclinical mastitis impairs NF-kappaB (show NFKB1 Proteins) activation in MEC (show CCL28 Proteins) thereby severely weakening the immune response,induction of IL-8 (show IL8 Proteins) and TNFalpha (show TNF Proteins), in the udder

  7. These results confirm that VEGI (show TNFSF15 Proteins) utilizes NF-kappaB (show NFKB1 Proteins) as a pro-survival role factor in endothelial cells.

RELA Protein Profile

Protein Summary

NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with RELA

  • v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA)
  • v-rel reticuloendotheliosis viral oncogene homolog A (avian) (RELA)
  • NFKB3 protein
  • p65 protein

Protein level used designations for RELA

NF-kappa-B p65delta3 , nuclear factor NF-kappa-B p65 subunit , nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 , transcription factor p65 , v-rel reticuloendotheliosis viral oncogene homolog A , NF-kB p65 subunit , NF-kappaB transcription factor p65 subunit , v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65

5970 Homo sapiens
396027 Gallus gallus
508233 Bos taurus
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