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Browse our TGFB1 Proteins (TGFB1)

Full name:
Transforming Growth Factor, beta 1 Proteins (TGFB1)
On www.antibodies-online.com are 117 Transforming Growth Factor, beta 1 (TGFB1) Proteins from 26 different suppliers available. Additionally we are shipping TGFB1 Antibodies (397) and TGFB1 Kits (166) and many more products for this protein. A total of 703 TGFB1 products are currently listed.
Synonyms:
ai39657, betaig-h3, bigh3, cdb1, cdg2, cdgg1, ced, csd, csd1, csd2, csd3, dpd1, ebmd, lap, lcd1, MGC146225, tgf, tgf-beta, TGF-BETA-1, TGF-beta1, TGF-beta5, tgfb, Tgfb-1, TGFB1, TGFB4, tgfb5, tgfbeta, TGFbeta1, TGFBI, wu:fb13a07, xx:ai39657
list all proteins Gene Name GeneID UniProt
TGFB1 7040 P01137
TGFB1 59086 P17246
TGFB1 21803 P04202

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TGFB1 Proteins (TGFB1) by Origin

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Top referenced TGFB1 Proteins

  1. Human TGFB1 Protein expressed in CHO Cells - ABIN2666973 : Acosta-Rodriguez, Napolitani, Lanzavecchia, Sallusto: Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. in Nature immunology 2007 (PubMed)
    Show all 13 references for ABIN2666973

  2. Human TGFB1 Protein expressed in CHO Cells - ABIN809732 : Farges, Romeas, Melin, Pin, Lebecque, Lucchini, Bleicher, Magloire: TGF-beta1 induces accumulation of dendritic cells in the odontoblast layer. in Journal of dental research 2003 (PubMed)
    Show all 7 references for ABIN809732

  3. Rat (Rattus) TGFB1 Protein expressed in Human Cells - ABIN2009188 : Assoian, Komoriya, Meyers, Miller, Sporn: Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization. in The Journal of biological chemistry 1983 (PubMed)
    Show all 4 references for ABIN2009188

  4. Dog (Canine) TGFB1 Protein expressed in Human Cells - ABIN2008955 : Letterio, Roberts: Regulation of immune responses by TGF-beta. in Annual review of immunology 1998 (PubMed)
    Show all 3 references for ABIN2008955

  5. Human TGFB1 Protein expressed in CHO Cells - ABIN2003410 : Vaughn, Broussard, Hall, Scott, Blanton, Milunsky, Hecht: Confirmation of the mapping of the Camurati-Englemann locus to 19q13. 2 and refinement to a 3.2-cM region. in Genomics 2000 (PubMed)
    Show all 3 references for ABIN2003410

  6. Human TGFB1 Protein expressed in HEK293 - ABIN2039654 : Munger, Harpel, Gleizes, Mazzieri, Nunes, Rifkin: Latent transforming growth factor-beta: structural features and mechanisms of activation. in Kidney international 1997 (PubMed)
    Show all 3 references for ABIN2039654

  7. Human TGFB1 Protein expressed in HEK-293 Cells - ABIN2181808 : Derynck, Jarrett, Chen, Eaton, Bell, Assoian, Roberts, Sporn, Goeddel: Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells. in Nature 1985 (PubMed)

More Proteins for TGFB1 Interaction Partners

Rhesus Monkey Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. TGF-beta1 regulated pAKT (show AKT1 Proteins) and IFNgamma expressions were associated with epithelial cell survival in rhesus macaque colon explants and suggest a potential role of mucosal TGF-beta1 in regulating intestinal homeostasis and EC integrity.

  2. These findings suggest that FBLN5 (show FBLN5 Proteins) may interfere with choroidal neovascularization by downregulating VEGF (show VEGFA Proteins), CXCR4 (show CXCR4 Proteins), and TGFB1 expression and inhibiting choroidl endothelial cell proliferation.

  3. SIV infection of rhesus macaques results in the emergence of IL-17 (show IL17A Proteins)-expressing cells during the acute phase. This subpopulation appears at day 14 postinfection concomitantly with an increase in TGF-beta and IL-18 (show IL18 Proteins) expression.

  4. SIV-infected macaques exhibiting progression to AIDS displayed greater expression of TGF-beta and indoleamine 2,3 dioxygenase in CD8 (show CD8A Proteins)+ T cells from mesentric lymph nodes.

Zebrafish Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. The fine tuning of TGF-beta signaling derives from positive and negative control by Ldb2a (show LDB2 Proteins).

  2. TGFbeta1a regulates zebrafish posterior lateral line formation via Smad5 (show SMAD5 Proteins) mediated pathway.

  3. PCSK7 (show PCSK7 Proteins) is essential for zebrafish development and regulates the expression and proteolytic cleavage of TGFbeta1a.

  4. TGFbeta signaling orchestrates the beneficial interplay between scar-based repair and cardiomyocyte-based regeneration to achieve complete heart regeneration.

  5. TGFbeta1 plays a role in zebrafish keratocyte migration.

  6. data presented show that Zili suppresses TGF-beta signaling by physically associating with Smad4 (show SMAD4 Proteins) and preventing the formation of Smad2 (show SMAD2 Proteins)/3/4 and Smad1 (show SMAD1 Proteins)/5/9/4 complexes

  7. TGF-beta1 acts at multiple sites, including LH receptor (show LHCGR Proteins), 20beta-HSD (show HAL Proteins) and membrane progestin receptor-beta (show PAQR8 Proteins), to inhibit zebrafish oocyte maturation

  8. These data suggest Pez plays a crucial role in organogenesis by inducing TGFbeta and epithelial-mesenchymal transition.

  9. Data show that Rock2 (show ROCK2 Proteins) acts as a negative regulator of the TGFbeta signaling pathway.

Xenopus laevis Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. These data indicate that TGF-beta signaling is crucial for the function of the transition zone, which in turn may affect the regulation of cilia length.

  2. R-Smads are the key components of TGFbeta beta signals in germ layer induction. SCP3 (show SYCP3 Proteins) serves as a vegetally enriched, intrinsic factor (show GIF Proteins) to ensure a prepared status of Smads for their activation.

  3. the present in vitro system, which permits not only the cell contraction-mediated cell sorting but also the TGF-b-directed mesodermal induction such as cartilage formation, may fairly reflect the embryogenesis in vivo.

  4. Loss of XTgfbi impaired blastopore formation and dorsal tissue morphogenesis.

  5. TGF-beta signaling has a role in nuclear localization of transcription factor Smad4 (show SMAD4 Proteins)

  6. sortilin (show SORT1 Proteins) negatively regulates TGF-beta signaling by diverting trafficking of precursor proteins to the lysosome during transit through the biosynthetic pathway

Human Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. Paracrine Effect of Degenerated Disc Cells on Healthy Human Nucleus Pulposus Cells Is Mediated by MAPK (show MAPK1 Proteins) and NF-kappaB (show NFKB1 Proteins) Pathways and Can Be Reduced by TGF-beta1

  2. these results suggest that cytokeratin 18 (show KRT18 Proteins) critically contributes to initiating TGF-beta1-induced EMT (show ITK Proteins) via the smad 2 (show SMAD2 Proteins)/3-mediated regulation of snail (show SNAI1 Proteins) and slug (show SNAI2 Proteins) expression in breast epithelial cells.

  3. Craniofacial deformities seen in Loeys-Dietz Syndromes patients may reflect altered TGFbeta signaling in neural crest derivatives.

  4. A constant observation was that 1,25(OH)2D3 or synthetic ligands via the active vitamin D receptor (VDR) impede transforming growth factor (TGF)-beta/mothers against decapentaplegic homologs (SMADs) signaling in myofibroblasts regardless of the initiating insult. The translational impact of 1,25(OH)2D3 in targetting stromal CAFs is discussed

  5. these results suggest that TGF-beta1 stimulates HSC-4 cell invasion through the Slug (show SNAI2 Proteins)/Wnt-5b (show WNT5B Proteins)/MMP-10 (show MMP10 Proteins) signalling axis.

  6. TGFbeta1 was the direct target of miR (show MLXIP Proteins)-663 and mediated the effect of miR (show MLXIP Proteins)-663 on papillary thyroid carcinoma development. By targeting TGFbeta1, miR (show MLXIP Proteins)-663 efficiently regulates the expression of epithelial-mesenchymal transition markers and matrix metalloproteinases.

  7. overexpression of miR (show MLXIP Proteins)-93 in lung cancer cells promoted TGF-b-induced EMT (show ITK Proteins) through downregulation of NEDD4L (show NEDD4L Proteins). The analysis of publicly available gene expression array datasets indicates that low NEDD4L (show NEDD4L Proteins) expression correlates with poor outcomes among patients with lung cancer, further supporting the oncogenic role of miR (show MLXIP Proteins)-93 in lung tumorigenesis and metastasis.

  8. The molecular pathogenesis of radiotherapy-induced muscle fibrosis involves the TGF-beta1 pathway and its repression of MyoD (show MYOD1 Proteins) expression. Our results suggest a correlation between traditional swallow therapy /neuromuscular electrical stimulation combined therapy and the restoration of TGF-beta1/MyoD (show MYOD1 Proteins) homeostasis in cervical muscles.

  9. Profiles of N-glycopeptides / N-glycoproteins / N-glycosites in LX-2 cells, with and without activation by TGFB1, were identified and compared using hydrazide chemistry enrichment coupled with liquid chromatography - mass spectrometry analysis. A total of 103 non-redundant N-glycopeptides, with 107 glycosylation sites from 86 N-glycoproteins, were identified in activated and quiescent LX-2 cells respectively.

  10. It has now been shown that CTGF (show CTGF Proteins) expression is essential for multiplication of fibroblasts, and in its absence, the fibroblasts become unresponsive to agents like TGF-beta1 that normally enhance their growth

Pig (Porcine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. The results indicated that TGF-beta-1 was associated with the restoration of intestinal morphology and barrier function following weaning stress.

  2. Data (including data from in vitro and in vivo experiments) suggest that day 14 elongated conceptus secretes proteins that up-regulate TGFbeta1 mRNA and TGFbeta1 expression in endometrium; TGFbeta1 may be important during pregnancy maintenance.

  3. The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10 (show IL10 Proteins), and IL-6 (show IL6 Proteins) in ovarian follicles are reported.

  4. Dietary (1,3/1,6)-beta-D-glucan reduced the mRNA expression of transforming growth factor (TGF) beta2 (show TGFB2 Proteins) and tended to reduce the mRNA expression of TGF-beta1 in lung tissue of neonatal piglet.

  5. TGF-beta1, via TGF-beta1 receptor I and p38 MAPK (show MAPK14 Proteins) signaling, reduces CFTR (show CFTR Proteins) expression to impair CFTR (show CFTR Proteins)-mediated anion secretion, which would likely compound the effects associated with mild CFTR (show CFTR Proteins) mutations and ultimately would compromise male fertility.

  6. High yield isolation of BMP-2 (show BMP2 Proteins) from bone and in vivo activity of a combination of BMP-2 (show BMP2 Proteins)/TGF-beta1.

  7. Boar seminal plasma contained TGF- beta1 and IL-10 (show IL10 Proteins) but with high individual variation.

  8. The present study was aimed to determine the association between metalloproteinase 3 (MMP3 (show MMP3 Proteins)), transforming growth factor beta 1 (TGFbeta1) and collagen type X alpha I (COL10A1 (show COL10A1 Proteins)) gene polymorphisms with traits related to leg weakness in pigs.

  9. Inhibition of transforming growth factor beta-1 augments liver regeneration after partial portal vein ligation in a porcine experimental model.

  10. TGF-beta prevents excessive heart valve growth under normal physiological conditions while it promotes cell proliferation in the early stages of repair.

Cow (Bovine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. The results identify TGFB1 and ESRRA (show ESRRA Proteins) as likely transcriptional regulators of rumen epithelial development and energy metabolism, respectively, and provide targets for modulation of rumen development and function in the growing calf.

  2. the combined treatment with TGF-beta1 and BMP-7 (show BMP7 Proteins) or treatment first with TGF-beta1 followed by BMP-7 (show BMP7 Proteins) was more effective than other treatment groups in both chondrogenic differentiation and SZP (show PRG4 Proteins) secretion.

  3. Tenascin-X (show TNXB Proteins) promotes activation of latent TGF-beta1 and subsequent epithelial to mesenchymal transition in mammary epithelial cells.

  4. a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Proteins)/5/8 and Smad2 (show SMAD2 Proteins)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Proteins).

  5. Endogenous TGF-beta1 became more bioactive following activation of the transgene protein product in chondrocytes.

  6. A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.

  7. Data show that TGF-beta pathways operate during ovarian fetal development, and fibrillin 3 is highly expressed at a critical stage early in developing human and bovine fetal ovaries.

  8. Role of TGF-beta1 and TNF-alpha (show TNF Proteins) in IL-1beta (show IL1B Proteins) mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease.

  9. vascular endothelial growth factor indirectly stimulates smooth muscle cell proliferation and migration through the modulation of basic fibroblast growth factor (show FGF2 Proteins) and transforming growth factor beta(1) released by endothelial cells

  10. Data show that as antral follicles develop, transforming growth factor (TGF)-beta3 (show TGFB3 Proteins) is the most abundant TGF-beta isoform and TGF-beta1 protein levels decline in large follicles.

Mouse (Murine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. Pro-fibrotic cardiac effect of miR (show MLXIP Proteins)-328 was mediated by down-regulating TGFbR3 (show TGFBR3 Proteins) and up-regulating TGFb1.

  2. Activation of CB2 (show CNR2 Proteins) ameliorates myocardial fibrosis via Nrf2 (show NFE2L2 Proteins)-mediated inhibition of TGF-beta1/Smad3 (show SMAD3 Proteins) pathway in mice with myocardial infarction.

  3. Data show that regulation of interleukin-6 (IL-6 (show IL6 Proteins)) on transforming growth factor beta1 (TGFbeta1) and microRNA miR (show MLXIP Proteins)-29 pathway reduced myocardial fibrosis and improved cardiac function of diabetic mice.

  4. T3 reduces occupancy of SMAD (show SMAD1 Proteins)-binding elements in response to TGF-beta, reducing histone acetylation and inhibiting transcription. In agreement with this transcriptional cross-talk, T3 is able to antagonize fibrotic processes in vivo.

  5. This study found evidence of increased leukocyte phosphorylated-Smad2 (show SMAD2 Proteins)/3 staining in both single leukocytes and platelet-leukocyte aggregates in mice that developed aortic valve stenosis, suggesting the presence of increased circulating active TGF-beta1.

  6. Findings establish that transforming growth factor-beta1 activates TGF-beta receptor-I and its downstream p38 MAPK (show MAPK14 Proteins) and PI3K-Akt (show AKT1 Proteins) signaling pathways in microglia to protect against dopaminergic neuronal loss that characterizes in Parkinson's disease.

  7. The findings in this study strongly suggest the following: i) that VEGF-C promotes the proliferative activity and migratory ability of mesenchymal stem cell ; and ii) VEGF-C and Tgfb reciprocally regulate mesenchymal stem cell commitment to differentiation into lymphatic endothelial or osteoblastic phenotypes, respectively.

  8. Interactions among the TGF-beta signalling pathways, Jagged2 (show JAG2 Proteins)/Notch1 (show NOTCH1 Proteins) signalling pathways and epigenetic modifications regulate the expansion of lingual epithelial stem cells.

  9. tumor antigen-specific vaccination in combination with focal radiation therapy reversed tolerance and improved survival. This treatment regimen was associated with increased polyfunctionality of CD8 (show CD8A Proteins) T cells, elevated T effector to T regulatory cell ratios, and decreased TGFbeta secretion from microglia.

  10. TGF-beta1 increased the expression of TREM-1 (show TREM1 Proteins) in mouse macrophages partly via the transcription factor AP-1 (show JUN Proteins).

Rabbit Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.

  2. cell therapy promoted TGF-beta1 expression in nucleus pulposus, leading to anti-inflammatory effects via the inhibition of NF-kappaB (show NFKB1 Proteins), and the amelioration of disc degradation.

  3. that prenatal tracheal occlusion increases TGF-beta/Rho kinase (show ROCK1 Proteins) pathway, myofibroblast differentiation, and matrix deposition in neonatal rabbit and human congenital diaphragmatic hernia lungs

  4. observation. Based on the above results, we conclude that TGF-beta1-immobilized PLGA-gelatin scaffold seeded with ASCs considerably enhances the quality of the tissue-engineered cartilage, therefore, advancing the field of cartilage tissue engineering

  5. Smad7 (show SMAD7 Proteins) plays a crucial role in antagonizing epithelial-mesenchymal transition induced by TGFbeta signaling and is a Notch (show NOTCH1 Proteins) signaling target in limbal epithelial stem cells.

  6. the role of IL-10 in inhibited allograft rejection may be associated with CD4+CD25+ regulatory T cells and IL-10, and may be independent of TGF-b

  7. After NOTCH1 (show NOTCH1 Proteins) knockdown and TGFB1 stimulation, rabbit mesenchymal stem cells expressed higher levels of proteoglycan (show Vcan Proteins) and collagen II.

  8. TGF-beta1 gene transcription significantly correlates with the surgical vaginal and dermal wound closure rate.

  9. A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.

  10. Wound closure was significantly protracted (P < 0.02), whereas TGFbeta1 gene expression was significantly increased (P < 0.0001) during the wound healing process in oophorectomised rabbits.

Guinea Pig Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. TGF beta is involved in the pathogenesis of tympanosclerosis.

  2. There was significantly higher expression of TGF-beta1 and MMP-9 (show MMP9 Proteins) in nasal mucosa of experimental allergic rhinitis guinea pigs than in controls.

Horse (Equine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. Within the limitations of the study design, production of COMP (show COMP Proteins) during healing of skin wounds does not appear to be influenced by wound type or anatomic site, nor does it appear to be correlated with TGF-beta1 concentrations.

  2. Peritoneal TGF-beta(1) concentration was higher in horses with severe gastrointestinal diseases, in horses with an altered peritoneal fluid, and in nonsurvivors.

TGFB1 Protein Profile

Protein Summary

This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.

Alternative names and synonyms associated with TGFB1

  • transforming growth factor, beta 1 (TGFB1)
  • transforming growth factor, beta 1a (tgfb1a)
  • transforming growth factor, beta-induced, 68kDa (TGFBI)
  • transforming growth factor, beta-induced, 68kDa (tgfbi)
  • transforming growth factor, beta-induced, 68kDa (LOC100227786)
  • transforming growth factor beta 1 (TGFB1)
  • transforming growth factor, beta 1 (Tgfb1)
  • transforming growth factor, beta 1 (tgfb1)
  • transforming growth factor, beta 1 (tgf)
  • ai39657 protein
  • betaig-h3 protein
  • bigh3 protein
  • cdb1 protein
  • cdg2 protein
  • cdgg1 protein
  • ced protein
  • csd protein
  • csd1 protein
  • csd2 protein
  • csd3 protein
  • dpd1 protein
  • ebmd protein
  • lap protein
  • lcd1 protein
  • MGC146225 protein
  • tgf protein
  • tgf-beta protein
  • TGF-BETA-1 protein
  • TGF-beta1 protein
  • TGF-beta5 protein
  • tgfb protein
  • Tgfb-1 protein
  • TGFB1 protein
  • TGFB4 protein
  • tgfb5 protein
  • tgfbeta protein
  • TGFbeta1 protein
  • TGFBI protein
  • wu:fb13a07 protein
  • xx:ai39657 protein

Protein level used designations for TGFB1

transforming growth factor beta1 , transforming growth factor, beta 1 , transforming growth factor, beta-induced, 68kDa , transforming growth factor-beta-induced protein ig-h3-like , transforming growth factor beta-1-like , TGF-beta-1 , transforming growth factor beta 4 , transforming growth factor beta-1 , TGF-beta 1 protein , latency-associated peptide , transforming growth factor, beta 1 (Camurati-Engelmann disease) , transforming growth factor-beta-1 , TGF-beta 1 , transforming growth factor-beta 1 , transforming growth factor, beta-1 , transforming growth factor beta 1 , regulatory protein , transforming growth factor-beta , TGF-beta-5 , tgf beta , tgf-beta 5 , transforming gorwth factor-Beta5 , transforming growth factor-B5 , transforming growth factor-beta 5 , Transforming growth factor beta-1

GENE ID SPECIES
574135 Macaca mulatta
359834 Danio rerio
768263 Felis catus
456060 Pan troglodytes
462081 Pan troglodytes
481519 Canis lupus familiaris
495971 Xenopus laevis
712503 Macaca mulatta
779782 Xenopus (Silurana) tropicalis
100227786 Taeniopygia guttata
100397340 Callithrix jacchus
100401979 Callithrix jacchus
100441300 Pongo abelii
100459982 Pongo abelii
100580274 Nomascus leucogenys
100581386 Nomascus leucogenys
100873157 Gallus gallus
7040 Homo sapiens
397078 Sus scrofa
443417 Ovis aries
59086 Rattus norvegicus
403998 Canis lupus familiaris
282089 Bos taurus
21803 Mus musculus
100008645 Oryctolagus cuniculus
100135628 Cavia porcellus
100033900 Equus caballus
397778 Xenopus laevis
100136774 Oncorhynchus mykiss
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