Browse our TGFB1 Proteins (TGFB1)

Full name:
Transforming Growth Factor, beta 1 Proteins (TGFB1)
On are 116 Transforming Growth Factor, beta 1 (TGFB1) Proteins from 26 different suppliers available. Additionally we are shipping TGFB1 Antibodies (452) and TGFB1 Kits (193) and many more products for this protein. A total of 784 TGFB1 products are currently listed.
ai39657, betaig-h3, bigh3, cdb1, cdg2, cdgg1, ced, csd, csd1, csd2, csd3, dpd1, ebmd, lap, lcd1, MGC146225, tgf, tgf-beta, TGF-BETA-1, TGF-beta1, TGF-beta5, tgfb, Tgfb-1, TGFB1, TGFB4, tgfb5, tgfbeta, TGFbeta1, TGFBI, wu:fb13a07, xx:ai39657
list all proteins Gene Name GeneID UniProt
TGFB1 7040 P01137
TGFB1 59086 P17246
TGFB1 21803 P04202

Show all synonyms

TGFB1 Proteins (TGFB1) by Origin

Select your origin of interest

Top referenced TGFB1 Proteins

  1. Human TGFB1 Protein expressed in CHO Cells - ABIN2666973 : Acosta-Rodriguez, Napolitani, Lanzavecchia, Sallusto: Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. in Nature immunology 2007 (PubMed)
    Show all 13 references for 2666973

  2. Rat (Rattus) TGFB1 Protein expressed in Human Cells - ABIN2009188 : Assoian, Komoriya, Meyers, Miller, Sporn: Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization. in The Journal of biological chemistry 1983 (PubMed)
    Show all 4 references for 2009188

  3. Dog (Canine) TGFB1 Protein expressed in Human Cells - ABIN2008955 : Letterio, Roberts: Regulation of immune responses by TGF-beta. in Annual review of immunology 1998 (PubMed)
    Show all 3 references for 2008955

  4. Human TGFB1 Protein expressed in HEK293 - ABIN2039654 : Munger, Harpel, Gleizes, Mazzieri, Nunes, Rifkin: Latent transforming growth factor-beta: structural features and mechanisms of activation. in Kidney international 1997 (PubMed)
    Show all 3 references for 2039654

  5. Human TGFB1 Protein expressed in CHO Cells - ABIN2003410 : Vaughn, Broussard, Hall, Scott, Blanton, Milunsky, Hecht: Confirmation of the mapping of the Camurati-Englemann locus to 19q13. 2 and refinement to a 3.2-cM region. in Genomics 2000 (PubMed)
    Show all 3 references for 2003410

  6. Human TGFB1 Protein expressed in HEK-293 Cells - ABIN2181808 : Derynck, Jarrett, Chen, Eaton, Bell, Assoian, Roberts, Sporn, Goeddel: Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells. in Nature 1985 (PubMed)

  7. Human TGFB1 Protein expressed in HEK-293 Cells - ABIN2733505 : Wang, Reece, Yang: Oxidative stress is responsible for maternal diabetes-impaired transforming growth factor beta signaling in the developing mouse heart. in American journal of obstetrics and gynecology 2015 (PubMed)

More Proteins for TGFB1 Interaction Partners

Rhesus Monkey Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. TGF-beta1 regulated pAKT (show AKT1 Proteins) and IFNgamma expressions were associated with epithelial cell survival in rhesus macaque colon explants and suggest a potential role of mucosal TGF-beta1 in regulating intestinal homeostasis and EC integrity.

  2. These findings suggest that FBLN5 (show FBLN5 Proteins) may interfere with choroidal neovascularization by downregulating VEGF (show VEGFA Proteins), CXCR4 (show CXCR4 Proteins), and TGFB1 expression and inhibiting choroidl endothelial cell proliferation.

  3. SIV infection of rhesus macaques results in the emergence of IL-17 (show IL17A Proteins)-expressing cells during the acute phase. This subpopulation appears at day 14 postinfection concomitantly with an increase in TGF-beta and IL-18 (show IL18 Proteins) expression.

  4. SIV-infected macaques exhibiting progression to AIDS displayed greater expression of TGF-beta and indoleamine 2,3 dioxygenase in CD8 (show CD8A Proteins)+ T cells from mesentric lymph nodes.

Zebrafish Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. transforming growth factor beta (TGFbeta) is required for hematopoietic progenitor cell specification. The requirement for TGFbeta is two fold and sequential: autocrine via Tgfbeta1a and Tgfbeta1b produced in the endothelial cells themselves, followed by a paracrine input of Tgfbeta3 from the notochord, suggesting that the former programs the hemogenic endothelium and the latter drives endothelial-to-hematopoietic tran...

  2. The fine tuning of TGF-beta signaling derives from positive and negative control by Ldb2a (show LDB2 Proteins).

  3. TGFbeta1a regulates zebrafish posterior lateral line formation via Smad5 (show SMAD5 Proteins) mediated pathway.

  4. PCSK7 (show PCSK7 Proteins) is essential for zebrafish development and regulates the expression and proteolytic cleavage of TGFbeta1a.

  5. TGFbeta signaling orchestrates the beneficial interplay between scar-based repair and cardiomyocyte-based regeneration to achieve complete heart regeneration.

  6. TGFbeta1 plays a role in zebrafish keratocyte migration.

  7. data presented show that Zili suppresses TGF-beta signaling by physically associating with Smad4 (show SMAD4 Proteins) and preventing the formation of Smad2 (show SMAD2 Proteins)/3/4 and Smad1 (show SMAD1 Proteins)/5/9/4 complexes

  8. TGF-beta1 acts at multiple sites, including LH receptor (show LHCGR Proteins), 20beta-HSD (show HAL Proteins) and membrane progestin receptor-beta (show PAQR8 Proteins), to inhibit zebrafish oocyte maturation

  9. These data suggest Pez (show PTPN14 Proteins) plays a crucial role in organogenesis by inducing TGFbeta and epithelial-mesenchymal transition.

  10. Data show that Rock2 (show ROCK2 Proteins) acts as a negative regulator of the TGFbeta signaling pathway.

Xenopus laevis Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. These data indicate that TGF-beta signaling is crucial for the function of the transition zone, which in turn may affect the regulation of cilia length.

  2. R-Smads are the key components of TGFbeta beta signals in germ layer induction. SCP3 (show SYCP3 Proteins) serves as a vegetally enriched, intrinsic factor (show GIF Proteins) to ensure a prepared status of Smads for their activation.

  3. the present in vitro system, which permits not only the cell contraction-mediated cell sorting but also the TGF-b-directed mesodermal induction such as cartilage formation, may fairly reflect the embryogenesis in vivo.

  4. Loss of XTgfbi impaired blastopore formation and dorsal tissue morphogenesis.

  5. TGF-beta signaling has a role in nuclear localization of transcription factor Smad4 (show SMAD4 Proteins)

  6. sortilin (show SORT1 Proteins) negatively regulates TGF-beta signaling by diverting trafficking of precursor proteins to the lysosome during transit through the biosynthetic pathway

Human Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. In response to TGF-beta, RASSF1A (show RASSF1 Proteins) is recruited to TGF-beta receptor I and targeted for degradation by the co-recruited E3 ubiquitin ligase (show MUL1 Proteins) ITCH. RASSF1A (show RASSF1 Proteins) degradation is necessary to permit Hippo pathway effector YAP1 (show YAP1 Proteins) association with SMADs and subsequent nuclear translocation of receptor-activated SMAD2 (show SMAD2 Proteins).

  2. RCCD1 as a novel regulator of TGF-beta-induced epithelial mesenchymal transformation and cell migration in non-small lung carcinoma cells.

  3. ASPP2 (show TP53BP2 Proteins) suppresses invasion, peritoneal dissemination and TGF-beta1-induced EMT (show ITK Proteins) by inhibiting Smad7 (show SMAD7 Proteins) degradation mediated by ITCH in gastric cancer cells.

  4. These abnormalities are associated with increased transforming growth factor-b (show ATP5S Proteins) signaling and defects in matrix metalloproteinase 9 (show MMP9 Proteins) activity. Our data demonstrate that lamin A/C (show LMNA Proteins) gene mutations responsible for FPLD2 (show LMNA Proteins) and related lipodystrophies are associated with transforming growth factor-beta activation

  5. STAT3 (show STAT3 Proteins) activation promotes ERBIN (show ERBB2IP Proteins) expression and negatively regulates TGF-beta activity by the formation of a STAT3 (show STAT3 Proteins)-ERBIN (show ERBB2IP Proteins)-SMAD2 (show SMAD2 Proteins)/3 complex.

  6. These studies support previously unrecognized, cooperative interaction between the CCN1 (show CCNA2 Proteins) matricellular protein and canonical TGF-beta1/SMAD3 (show SMAD3 Proteins) signaling that promotes lung fibrosis.

  7. Our data demonstrate that N-Cadherin (show CDH2 Proteins) was markedly overexpressed and miR (show MLXIP Proteins)-199b-5p was significantly downregulated in hepatocellular carcinoma (HCC (show FAM126A Proteins)). MiR (show MLXIP Proteins)-199b-5p exerts inhibitory effects on EMT (show ITK Proteins), and directly targets N-cadherin (show CDH2 Proteins) in HCC (show FAM126A Proteins), supporting the potential utility of miR (show MLXIP Proteins)-199b-5p as a promising strategy to treat HCC (show FAM126A Proteins)

  8. Simvastatin attenuates the tumor-associated macrophage mediated gemcitabine resistance of PDAC by blocking the TGF-beta1/Gfi-1 axis.

  9. In hepatocellular carcinoma, TGFB1 expression most frequently correlates with a partial EMT (show ITK Proteins), increase in mesenchymal genes and CD44 (show CD44 Proteins) expression, as well as maintenance or over-expression of epithelial-related genes.

  10. c-Abl (show ABL1 Proteins) promotes TGF-beta-induced SKIP/Smad3 (show SMAD3 Proteins) interaction.

Pig (Porcine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. TGF-beta1-induced epithelial-myofibroblast plasticity is FAK (show PTK2 Proteins)- dependent, whereas TGF-beta1-induced apoptosis is favored when FAK (show PTK2 Proteins) signaling is inhibited.

  2. this study shows that TGF-beta1 protects intestinal integrity and influences Smad (show SMAD1 Proteins) and MAPK (show MAPK1 Proteins) signal pathways in intestinal epithelium cells after TNF-alpha (show TNF Proteins) challenge

  3. this study shows that anemonin may ameliorate LPS (show IRF6 Proteins)-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR (show EGFR Proteins) signaling pathways

  4. The results indicated that TGF-beta-1 was associated with the restoration of intestinal morphology and barrier function following weaning stress.

  5. Data (including data from in vitro and in vivo experiments) suggest that day 14 elongated conceptus secretes proteins that up-regulate TGFbeta1 mRNA and TGFbeta1 expression in endometrium; TGFbeta1 may be important during pregnancy maintenance.

  6. The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10 (show IL10 Proteins), and IL-6 (show IL6 Proteins) in ovarian follicles are reported.

  7. Dietary (1,3/1,6)-beta-D-glucan reduced the mRNA expression of transforming growth factor (TGF) beta2 (show TGFB2 Proteins) and tended to reduce the mRNA expression of TGF-beta1 in lung tissue of neonatal piglet.

  8. TGF-beta1, via TGF-beta1 receptor I and p38 MAPK (show MAPK14 Proteins) signaling, reduces CFTR (show CFTR Proteins) expression to impair CFTR (show CFTR Proteins)-mediated anion secretion, which would likely compound the effects associated with mild CFTR (show CFTR Proteins) mutations and ultimately would compromise male fertility.

  9. High yield isolation of BMP-2 (show BMP2 Proteins) from bone and in vivo activity of a combination of BMP-2 (show BMP2 Proteins)/TGF-beta1.

  10. Boar seminal plasma contained TGF- beta1 and IL-10 (show IL10 Proteins) but with high individual variation.

Cow (Bovine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. Taken together, Staphylococcus aureus induces TGF-beta1 and bFGF (show FGF2 Proteins) expression through the activation of AP-1 (show JUN Proteins) and NF-kappaB (show NFKB1 Proteins) in bovine mammary gland fibroblasts.

  2. The results identify TGFB1 and ESRRA (show ESRRA Proteins) as likely transcriptional regulators of rumen epithelial development and energy metabolism, respectively, and provide targets for modulation of rumen development and function in the growing calf.

  3. the combined treatment with TGF-beta1 and BMP-7 (show BMP7 Proteins) or treatment first with TGF-beta1 followed by BMP-7 (show BMP7 Proteins) was more effective than other treatment groups in both chondrogenic differentiation and SZP (show PRG4 Proteins) secretion.

  4. Tenascin-X (show TNXB Proteins) promotes activation of latent TGF-beta1 and subsequent epithelial to mesenchymal transition in mammary epithelial cells.

  5. a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Proteins)/5/8 and Smad2 (show SMAD2 Proteins)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Proteins).

  6. Endogenous TGF-beta1 became more bioactive following activation of the transgene protein product in chondrocytes.

  7. A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.

  8. Data show that TGF-beta pathways operate during ovarian fetal development, and fibrillin 3 is highly expressed at a critical stage early in developing human and bovine fetal ovaries.

  9. Role of TGF-beta1 and TNF-alpha (show TNF Proteins) in IL-1beta (show IL1B Proteins) mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease.

  10. vascular endothelial growth factor indirectly stimulates smooth muscle cell proliferation and migration through the modulation of basic fibroblast growth factor (show FGF2 Proteins) and transforming growth factor beta(1) released by endothelial cells

Mouse (Murine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. Studied endothelial cell-specific activation of TGF-beta signaling in tissue fibrosis and vasculopathy. Constitutive TGFbeta-1 signaling in endothelial cells resulted in cutaneous and visceral fibrosis.

  2. data show that the combination of cell lineage, immune mediators and both dietary and microbe-derived environmental factors shape intestinal dendritic cells into critical gatekeepers of TGF-beta-dependent immune responses through regulation of beta8 integrin expression

  3. Study found that transforming growth factor-beta (TGF-beta) is an upstream regulator of vascular endothelial growth factor (VEGF), whereas VEGF pathway activity does not alter the TGF-beta pathway in vitro.

  4. overexpression of Fam3c (show FAM3C Proteins) caused reduction of Runx2 (show RUNX2 Proteins) expression at both mRNA and protein levels. Fam3c (show FAM3C Proteins) was localized in the cytoplasm and it was not secreted outside the cell during osteoblast differentiation and therefore, may function intracellularly. Furthermore, Fam3c (show FAM3C Proteins) and TGF-beta1 were found to regulate each other reciprocally

  5. this study shows that the presence of IFN-alpha (show IFNA Proteins) at antigen sensitization activates an IDO1 (show IDO1 Proteins)/TGF-beta-dependent anti-inflammatory program that upon antigenic rechallenge prevents inflammation via plasmacytoid dendritic cells

  6. We show that astrocytes prevent synapse loss induced by AbetaOs, via production of transforming growth factor-beta1 (TGF-beta1). We found that AbetaOs trigger morphological and functional alterations in astrocytes, and impair their neuroprotective potential.

  7. this study shows that sodium benzoate induces the expression of TGF-beta in splenocytes and alleviates experimental allergic encephalomyelitis via the STAT6 (show STAT6 Proteins)-TGF-beta-Treg pathway

  8. IL-33 (show IL33 Proteins) receptor-expressing regulatory T cells are highly activated, Th2 biased and suppress CD4 (show CD4 Proteins) T cell proliferation through IL-10 (show IL10 Proteins) and TGFbeta release.

  9. triptolide enhances the suppressive effects of Tregs on osteoclast differentiation and bone resorption by enhancing the secretion of IL-10 (show IL10 Proteins) and TGF-beta1

  10. Cav-1 (show CAV1 Proteins) depletion, oxidative stress-mediated reduction in BMPRII (show BMPR2 Proteins) expression, and enhanced TGF-beta-driven SMAD-2 (show SMAD2 Proteins)/3 signaling promote pulmonary vascular remodeling in inflamed lungs.

Rabbit Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. Data indicate that cardiac contractility modulation (CCM) therapy exerted protective effects against myocardial fibrosis potentially by inhibiting TGF-beta1/Smad3 (show SMAD3 Proteins) signaling pathway in chronic heart failure .

  2. study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.

  3. cell therapy promoted TGF-beta1 expression in nucleus pulposus, leading to anti-inflammatory effects via the inhibition of NF-kappaB (show NFKB1 Proteins), and the amelioration of disc degradation.

  4. that prenatal tracheal occlusion increases TGF-beta/Rho kinase (show ROCK1 Proteins) pathway, myofibroblast differentiation, and matrix deposition in neonatal rabbit and human congenital diaphragmatic hernia lungs

  5. observation. Based on the above results, we conclude that TGF-beta1-immobilized PLGA-gelatin scaffold seeded with ASCs considerably enhances the quality of the tissue-engineered cartilage, therefore, advancing the field of cartilage tissue engineering

  6. Smad7 (show SMAD7 Proteins) plays a crucial role in antagonizing epithelial-mesenchymal transition induced by TGFbeta signaling and is a Notch (show NOTCH1 Proteins) signaling target in limbal epithelial stem cells.

  7. the role of IL-10 in inhibited allograft rejection may be associated with CD4+CD25+ regulatory T cells and IL-10, and may be independent of TGF-b

  8. After NOTCH1 (show NOTCH1 Proteins) knockdown and TGFB1 stimulation, rabbit mesenchymal stem cells expressed higher levels of proteoglycan (show Vcan Proteins) and collagen II.

  9. TGF-beta1 gene transcription significantly correlates with the surgical vaginal and dermal wound closure rate.

  10. A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.

Guinea Pig Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. TGF beta is involved in the pathogenesis of tympanosclerosis.

  2. There was significantly higher expression of TGF-beta1 and MMP-9 (show MMP9 Proteins) in nasal mucosa of experimental allergic rhinitis guinea pigs than in controls.

Horse (Equine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. Within the limitations of the study design, production of COMP (show COMP Proteins) during healing of skin wounds does not appear to be influenced by wound type or anatomic site, nor does it appear to be correlated with TGF-beta1 concentrations.

  2. Peritoneal TGF-beta(1) concentration was higher in horses with severe gastrointestinal diseases, in horses with an altered peritoneal fluid, and in nonsurvivors.

TGFB1 Protein Profile

Protein Summary

This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.

Alternative names and synonyms associated with TGFB1

  • transforming growth factor, beta 1 (TGFB1)
  • transforming growth factor, beta 1a (tgfb1a)
  • transforming growth factor, beta-induced, 68kDa (TGFBI)
  • transforming growth factor, beta-induced, 68kDa (tgfbi)
  • transforming growth factor, beta-induced, 68kDa (LOC100227786)
  • transforming growth factor beta 1 (TGFB1)
  • transforming growth factor, beta 1 (Tgfb1)
  • transforming growth factor, beta 1 (tgfb1)
  • transforming growth factor, beta 1 (tgf)
  • ai39657 protein
  • betaig-h3 protein
  • bigh3 protein
  • cdb1 protein
  • cdg2 protein
  • cdgg1 protein
  • ced protein
  • csd protein
  • csd1 protein
  • csd2 protein
  • csd3 protein
  • dpd1 protein
  • ebmd protein
  • lap protein
  • lcd1 protein
  • MGC146225 protein
  • tgf protein
  • tgf-beta protein
  • TGF-BETA-1 protein
  • TGF-beta1 protein
  • TGF-beta5 protein
  • tgfb protein
  • Tgfb-1 protein
  • TGFB1 protein
  • TGFB4 protein
  • tgfb5 protein
  • tgfbeta protein
  • TGFbeta1 protein
  • TGFBI protein
  • wu:fb13a07 protein
  • xx:ai39657 protein

Protein level used designations for TGFB1

transforming growth factor beta1 , transforming growth factor, beta 1 , transforming growth factor, beta-induced, 68kDa , transforming growth factor-beta-induced protein ig-h3-like , transforming growth factor beta-1-like , TGF-beta-1 , transforming growth factor beta 4 , transforming growth factor beta-1 , TGF-beta 1 protein , latency-associated peptide , transforming growth factor, beta 1 (Camurati-Engelmann disease) , transforming growth factor-beta-1 , TGF-beta 1 , transforming growth factor-beta 1 , transforming growth factor, beta-1 , transforming growth factor beta 1 , regulatory protein , transforming growth factor-beta , TGF-beta-5 , tgf beta , tgf-beta 5 , transforming gorwth factor-Beta5 , transforming growth factor-B5 , transforming growth factor-beta 5 , Transforming growth factor beta-1

574135 Macaca mulatta
359834 Danio rerio
768263 Felis catus
456060 Pan troglodytes
462081 Pan troglodytes
481519 Canis lupus familiaris
495971 Xenopus laevis
712503 Macaca mulatta
779782 Xenopus (Silurana) tropicalis
100227786 Taeniopygia guttata
100397340 Callithrix jacchus
100401979 Callithrix jacchus
100441300 Pongo abelii
100459982 Pongo abelii
100580274 Nomascus leucogenys
100581386 Nomascus leucogenys
100873157 Gallus gallus
7040 Homo sapiens
397078 Sus scrofa
443417 Ovis aries
59086 Rattus norvegicus
403998 Canis lupus familiaris
282089 Bos taurus
21803 Mus musculus
100008645 Oryctolagus cuniculus
100135628 Cavia porcellus
100033900 Equus caballus
397778 Xenopus laevis
100136774 Oncorhynchus mykiss
Selected quality suppliers for TGFB1 Proteins (TGFB1)
Did you look for something else?