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Browse our TGFB1 Proteins (TGFB1)

Full name:
Transforming Growth Factor, beta 1 Proteins (TGFB1)
On www.antibodies-online.com are 115 Transforming Growth Factor, beta 1 (TGFB1) Proteins from 25 different suppliers available. Additionally we are shipping TGFB1 Antibodies (437) and TGFB1 Kits (203) and many more products for this protein. A total of 778 TGFB1 products are currently listed.
Synonyms:
ai39657, betaig-h3, bigh3, cdb1, cdg2, cdgg1, ced, csd, csd1, csd2, csd3, dpd1, ebmd, lap, lcd1, MGC146225, tgf, tgf-beta, TGF-BETA-1, TGF-beta1, TGF-beta5, tgfb, Tgfb-1, TGFB1, TGFB4, tgfb5, tgfbeta, TGFbeta1, TGFBI, wu:fb13a07, xx:ai39657
list all proteins Gene Name GeneID UniProt
TGFB1 7040 P01137
TGFB1 59086 P17246
TGFB1 21803 P04202

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TGFB1 Proteins (TGFB1) by Origin

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Top referenced TGFB1 Proteins

  1. Human TGFB1 Protein expressed in CHO Cells - ABIN2666973 : Acosta-Rodriguez, Napolitani, Lanzavecchia, Sallusto: Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. in Nature immunology 2007 (PubMed)
    Show all 13 references for ABIN2666973

  2. Rat (Rattus) TGFB1 Protein expressed in Human Cells - ABIN2009188 : Assoian, Komoriya, Meyers, Miller, Sporn: Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization. in The Journal of biological chemistry 1983 (PubMed)
    Show all 4 references for ABIN2009188

  3. Dog (Canine) TGFB1 Protein expressed in Human Cells - ABIN2008955 : Letterio, Roberts: Regulation of immune responses by TGF-beta. in Annual review of immunology 1998 (PubMed)
    Show all 3 references for ABIN2008955

  4. Human TGFB1 Protein expressed in HEK293 - ABIN2039654 : Munger, Harpel, Gleizes, Mazzieri, Nunes, Rifkin: Latent transforming growth factor-beta: structural features and mechanisms of activation. in Kidney international 1997 (PubMed)
    Show all 3 references for ABIN2039654

  5. Human TGFB1 Protein expressed in CHO Cells - ABIN2003410 : Vaughn, Broussard, Hall, Scott, Blanton, Milunsky, Hecht: Confirmation of the mapping of the Camurati-Englemann locus to 19q13. 2 and refinement to a 3.2-cM region. in Genomics 2000 (PubMed)
    Show all 3 references for ABIN2003410

  6. Human TGFB1 Protein expressed in HEK-293 Cells - ABIN2181808 : Derynck, Jarrett, Chen, Eaton, Bell, Assoian, Roberts, Sporn, Goeddel: Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells. in Nature 1985 (PubMed)

More Proteins for TGFB1 Interaction Partners

Rhesus Monkey Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. TGF-beta1 regulated pAKT (show AKT1 Proteins) and IFNgamma expressions were associated with epithelial cell survival in rhesus macaque colon explants and suggest a potential role of mucosal TGF-beta1 in regulating intestinal homeostasis and EC integrity.

  2. These findings suggest that FBLN5 (show FBLN5 Proteins) may interfere with choroidal neovascularization by downregulating VEGF (show VEGFA Proteins), CXCR4 (show CXCR4 Proteins), and TGFB1 expression and inhibiting choroidl endothelial cell proliferation.

  3. SIV infection of rhesus macaques results in the emergence of IL-17 (show IL17A Proteins)-expressing cells during the acute phase. This subpopulation appears at day 14 postinfection concomitantly with an increase in TGF-beta and IL-18 (show IL18 Proteins) expression.

  4. SIV-infected macaques exhibiting progression to AIDS displayed greater expression of TGF-beta and indoleamine 2,3 dioxygenase in CD8 (show CD8A Proteins)+ T cells from mesentric lymph nodes.

Zebrafish Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. transforming growth factor beta (TGFbeta) is required for hematopoietic progenitor cell specification. The requirement for TGFbeta is two fold and sequential: autocrine via Tgfbeta1a and Tgfbeta1b produced in the endothelial cells themselves, followed by a paracrine input of Tgfbeta3 from the notochord, suggesting that the former programs the hemogenic endothelium and the latter drives endothelial-to-hematopoietic tran...

  2. The fine tuning of TGF-beta signaling derives from positive and negative control by Ldb2a (show LDB2 Proteins).

  3. TGFbeta1a regulates zebrafish posterior lateral line formation via Smad5 (show SMAD5 Proteins) mediated pathway.

  4. PCSK7 (show PCSK7 Proteins) is essential for zebrafish development and regulates the expression and proteolytic cleavage of TGFbeta1a.

  5. TGFbeta signaling orchestrates the beneficial interplay between scar-based repair and cardiomyocyte-based regeneration to achieve complete heart regeneration.

  6. TGFbeta1 plays a role in zebrafish keratocyte migration.

  7. data presented show that Zili suppresses TGF-beta signaling by physically associating with Smad4 (show SMAD4 Proteins) and preventing the formation of Smad2 (show SMAD2 Proteins)/3/4 and Smad1 (show SMAD1 Proteins)/5/9/4 complexes

  8. TGF-beta1 acts at multiple sites, including LH receptor (show LHCGR Proteins), 20beta-HSD (show HAL Proteins) and membrane progestin receptor-beta (show PAQR8 Proteins), to inhibit zebrafish oocyte maturation

  9. These data suggest Pez (show PTPN14 Proteins) plays a crucial role in organogenesis by inducing TGFbeta and epithelial-mesenchymal transition.

  10. Data show that Rock2 (show ROCK2 Proteins) acts as a negative regulator of the TGFbeta signaling pathway.

Xenopus laevis Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. These data indicate that TGF-beta signaling is crucial for the function of the transition zone, which in turn may affect the regulation of cilia length.

  2. R-Smads are the key components of TGFbeta beta signals in germ layer induction. SCP3 (show SYCP3 Proteins) serves as a vegetally enriched, intrinsic factor (show GIF Proteins) to ensure a prepared status of Smads for their activation.

  3. the present in vitro system, which permits not only the cell contraction-mediated cell sorting but also the TGF-b-directed mesodermal induction such as cartilage formation, may fairly reflect the embryogenesis in vivo.

  4. Loss of XTgfbi impaired blastopore formation and dorsal tissue morphogenesis.

  5. TGF-beta signaling has a role in nuclear localization of transcription factor Smad4 (show SMAD4 Proteins)

  6. sortilin (show SORT1 Proteins) negatively regulates TGF-beta signaling by diverting trafficking of precursor proteins to the lysosome during transit through the biosynthetic pathway

Human Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. TGF-beta1 increases PAI-1 (show SERPINE1 Proteins) expression in primary human esophageal epithelial cells and fibroblasts from patients with eosinophilic esophagitis

  2. the signal pathway of TGF-beta1/PI3K (show PIK3CA Proteins)/CTGF (show CTGF Proteins) plays an important role in the fibrogenesis of human lung epithelial cells.

  3. These studies identify TGFbeta2-TLR4 (show TLR4 Proteins) crosstalk as a novel pathway involved in ECM (show MMRN1 Proteins) regulation in the TM and ocular hypertension.

  4. Taken together, the results suggest that the decrease in collagen IV (show COL4 Proteins) in the dermo-epidermal junction, relative to age, could be due to a decrease in collagen IV (show COL4 Proteins) expression by senescent dermal fibroblasts and may involve TGF-beta1 signalling.

  5. reduced EMT (show ITK Proteins) in ovarian cancer cells upon co-activation with TGFbeta1 and LiCl as shown by the expressions of epithelial/mesenchymal markers and the EMT (show ITK Proteins) promoting factor, Snail1 (show SNAI1 Proteins), accompanied by decrease in the invasion and migration of the cells compared to individual pathway activation.

  6. Bapx1 (show NKX3-2 Proteins) indicates poor prognosis for gastric cancer patients by promoting tumor migration and invasion via TGF-beta-induced epithelial-mesenchymal transition.

  7. The increase in c-Jun N-terminal kinase (c-Jun) and specificity protein 1 (SP1 (show SP1 Proteins)) expressions was positively correlated with transforming growth factor beta 1 (TGFbeta1) in both high glucose-treated renal mesangial cells (HRMCs) and diabetic kidneys.

  8. In this review, we aim to shed light on the state-of-the-art in the signalling pathways induced by TGF-beta that are involved in different stages of liver physiology and pathology.

  9. Conversely, siRNA-mediated Klotho (show KL Proteins) silencing up-regulated Egr-1 (show EGR1 Proteins), FN, and Col (show HDAC1 Proteins) I expression and the p-Smad3/Smad3 (show SMAD3 Proteins) ratio. Moreover, the effects of si-Klotho (show KL Proteins) on Egr-1 (show EGR1 Proteins) expression were abolished by the TGF-beta1 inhibitor SB-431542. Klotho (show KL Proteins) overexpression can prevent mesangial ECM (show MMRN1 Proteins) production in high-glucose-treated human MCs (show SMCP Proteins), an effect that has been partially attributed to Egr-1 (show EGR1 Proteins) down-regulation facilitated by TGF-beta1/Smad3 (show SMAD3 Proteins) s...

  10. overexpressed miR185 could inhibit hypertrophic scarring fibroblast growth, and the underlying mechanism was mediated, at least partly, through the suppression of TGFbeta1 and Col1 expression.

Pig (Porcine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. this study shows that TGF-beta1 protects intestinal integrity and influences Smad (show SMAD1 Proteins) and MAPK (show MAPK1 Proteins) signal pathways in intestinal epithelium cells after TNF-alpha (show TNF Proteins) challenge

  2. this study shows that anemonin may ameliorate LPS (show IRF6 Proteins)-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR (show EGFR Proteins) signaling pathways

  3. The results indicated that TGF-beta-1 was associated with the restoration of intestinal morphology and barrier function following weaning stress.

  4. Data (including data from in vitro and in vivo experiments) suggest that day 14 elongated conceptus secretes proteins that up-regulate TGFbeta1 mRNA and TGFbeta1 expression in endometrium; TGFbeta1 may be important during pregnancy maintenance.

  5. The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10 (show IL10 Proteins), and IL-6 (show IL6 Proteins) in ovarian follicles are reported.

  6. Dietary (1,3/1,6)-beta-D-glucan reduced the mRNA expression of transforming growth factor (TGF) beta2 (show TGFB2 Proteins) and tended to reduce the mRNA expression of TGF-beta1 in lung tissue of neonatal piglet.

  7. TGF-beta1, via TGF-beta1 receptor I and p38 MAPK (show MAPK14 Proteins) signaling, reduces CFTR (show CFTR Proteins) expression to impair CFTR (show CFTR Proteins)-mediated anion secretion, which would likely compound the effects associated with mild CFTR (show CFTR Proteins) mutations and ultimately would compromise male fertility.

  8. High yield isolation of BMP-2 (show BMP2 Proteins) from bone and in vivo activity of a combination of BMP-2 (show BMP2 Proteins)/TGF-beta1.

  9. Boar seminal plasma contained TGF- beta1 and IL-10 (show IL10 Proteins) but with high individual variation.

  10. The present study was aimed to determine the association between metalloproteinase 3 (MMP3 (show MMP3 Proteins)), transforming growth factor beta 1 (TGFbeta1) and collagen type X alpha I (COL10A1 (show COL10A1 Proteins)) gene polymorphisms with traits related to leg weakness in pigs.

Cow (Bovine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. Taken together, Staphylococcus aureus induces TGF-beta1 and bFGF (show FGF2 Proteins) expression through the activation of AP-1 (show JUN Proteins) and NF-kappaB (show NFKB1 Proteins) in bovine mammary gland fibroblasts.

  2. The results identify TGFB1 and ESRRA (show ESRRA Proteins) as likely transcriptional regulators of rumen epithelial development and energy metabolism, respectively, and provide targets for modulation of rumen development and function in the growing calf.

  3. the combined treatment with TGF-beta1 and BMP-7 (show BMP7 Proteins) or treatment first with TGF-beta1 followed by BMP-7 (show BMP7 Proteins) was more effective than other treatment groups in both chondrogenic differentiation and SZP (show PRG4 Proteins) secretion.

  4. Tenascin-X (show TNXB Proteins) promotes activation of latent TGF-beta1 and subsequent epithelial to mesenchymal transition in mammary epithelial cells.

  5. a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Proteins)/5/8 and Smad2 (show SMAD2 Proteins)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Proteins).

  6. Endogenous TGF-beta1 became more bioactive following activation of the transgene protein product in chondrocytes.

  7. A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.

  8. Data show that TGF-beta pathways operate during ovarian fetal development, and fibrillin 3 is highly expressed at a critical stage early in developing human and bovine fetal ovaries.

  9. Role of TGF-beta1 and TNF-alpha (show TNF Proteins) in IL-1beta (show IL1B Proteins) mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease.

  10. vascular endothelial growth factor indirectly stimulates smooth muscle cell proliferation and migration through the modulation of basic fibroblast growth factor (show FGF2 Proteins) and transforming growth factor beta(1) released by endothelial cells

Mouse (Murine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. TGFbeta and KLF11 (show KLF11 Proteins) mediate critical, translationally relevant host and lesion-driven responses that enable establishment and progression of endometriosis.

  2. A decreased mRNA expression of GATA3 (show GATA3 Proteins) and TGF-beta was found in active VKH patients, which was correlated negatively with the DNA methylation (show HELLS Proteins) of these factors.

  3. the GARP (show LRRC32 Proteins)/LTGF-beta1 complex on Treg cells is a major source of TGF-beta1 needed for induction of pTreg cells during the process of oral tolerance.

  4. The results suggest that an antagonistic cascade exists between the TGF-beta1/Smad/deltaEF1 pathways and Npr1 expression and receptor signaling that is relevant to renal and vascular remodeling, and may be critical in the regulation of blood pressure and cardiovascular homeostasis.

  5. Results suggest that eplerenone (EPL) inhibits atrial fibrosis through interfering with transforming growth factor beta 1 (TGF-beta1) signaling.

  6. TGFbeta signaling contributes to development of pulmonary vascular remodeling by promoting the proliferation of vascular smooth muscle cells.

  7. Our study indicates that Ang II (show AGT Proteins) cannot induce TGF-beta activation without fibulin-2 (show FBLN2 Proteins) and that fibulin-2 (show FBLN2 Proteins) has an essential role in Ang II (show AGT Proteins)-induced TGF-beta signaling and subsequent myocardial fibrosis. Fibulin-2 (show FBLN2 Proteins) can be considered as a critical regulator of TGF-beta that induces myocardial fibrosis.

  8. Collectively, the data suggest that Cytl1 (show CYTL1 Proteins) plays an essential role in cardiac fibrosis likely through activating the TGF-beta-SMAD (show SMAD1 Proteins) signaling pathway.

  9. Survivin (show BIRC5 Proteins) was regulated by TGF-beta and was found to be highly expressed during mucosal healing following intestinal inflammation

  10. The disruption of decorin (show DCN Proteins)-restricted TGFbeta signalling leads to higher stiffness of articular cartilage matrix, rendering joints more resistant to osteoarthritis.

Rabbit Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. Data indicate that cardiac contractility modulation (CCM) therapy exerted protective effects against myocardial fibrosis potentially by inhibiting TGF-beta1/Smad3 (show SMAD3 Proteins) signaling pathway in chronic heart failure .

  2. study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.

  3. cell therapy promoted TGF-beta1 expression in nucleus pulposus, leading to anti-inflammatory effects via the inhibition of NF-kappaB (show NFKB1 Proteins), and the amelioration of disc degradation.

  4. that prenatal tracheal occlusion increases TGF-beta/Rho kinase (show ROCK1 Proteins) pathway, myofibroblast differentiation, and matrix deposition in neonatal rabbit and human congenital diaphragmatic hernia lungs

  5. observation. Based on the above results, we conclude that TGF-beta1-immobilized PLGA-gelatin scaffold seeded with ASCs considerably enhances the quality of the tissue-engineered cartilage, therefore, advancing the field of cartilage tissue engineering

  6. Smad7 (show SMAD7 Proteins) plays a crucial role in antagonizing epithelial-mesenchymal transition induced by TGFbeta signaling and is a Notch (show NOTCH1 Proteins) signaling target in limbal epithelial stem cells.

  7. the role of IL-10 in inhibited allograft rejection may be associated with CD4+CD25+ regulatory T cells and IL-10, and may be independent of TGF-b

  8. After NOTCH1 (show NOTCH1 Proteins) knockdown and TGFB1 stimulation, rabbit mesenchymal stem cells expressed higher levels of proteoglycan (show Vcan Proteins) and collagen II.

  9. TGF-beta1 gene transcription significantly correlates with the surgical vaginal and dermal wound closure rate.

  10. A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.

Guinea Pig Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. TGF beta is involved in the pathogenesis of tympanosclerosis.

  2. There was significantly higher expression of TGF-beta1 and MMP-9 (show MMP9 Proteins) in nasal mucosa of experimental allergic rhinitis guinea pigs than in controls.

Horse (Equine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

  1. Within the limitations of the study design, production of COMP (show COMP Proteins) during healing of skin wounds does not appear to be influenced by wound type or anatomic site, nor does it appear to be correlated with TGF-beta1 concentrations.

  2. Peritoneal TGF-beta(1) concentration was higher in horses with severe gastrointestinal diseases, in horses with an altered peritoneal fluid, and in nonsurvivors.

TGFB1 Protein Profile

Protein Summary

This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.

Alternative names and synonyms associated with TGFB1

  • transforming growth factor, beta 1 (TGFB1)
  • transforming growth factor, beta 1a (tgfb1a)
  • transforming growth factor, beta-induced, 68kDa (TGFBI)
  • transforming growth factor, beta-induced, 68kDa (tgfbi)
  • transforming growth factor, beta-induced, 68kDa (LOC100227786)
  • transforming growth factor beta 1 (TGFB1)
  • transforming growth factor, beta 1 (Tgfb1)
  • transforming growth factor, beta 1 (tgfb1)
  • transforming growth factor, beta 1 (tgf)
  • ai39657 protein
  • betaig-h3 protein
  • bigh3 protein
  • cdb1 protein
  • cdg2 protein
  • cdgg1 protein
  • ced protein
  • csd protein
  • csd1 protein
  • csd2 protein
  • csd3 protein
  • dpd1 protein
  • ebmd protein
  • lap protein
  • lcd1 protein
  • MGC146225 protein
  • tgf protein
  • tgf-beta protein
  • TGF-BETA-1 protein
  • TGF-beta1 protein
  • TGF-beta5 protein
  • tgfb protein
  • Tgfb-1 protein
  • TGFB1 protein
  • TGFB4 protein
  • tgfb5 protein
  • tgfbeta protein
  • TGFbeta1 protein
  • TGFBI protein
  • wu:fb13a07 protein
  • xx:ai39657 protein

Protein level used designations for TGFB1

transforming growth factor beta1 , transforming growth factor, beta 1 , transforming growth factor, beta-induced, 68kDa , transforming growth factor-beta-induced protein ig-h3-like , transforming growth factor beta-1-like , TGF-beta-1 , transforming growth factor beta 4 , transforming growth factor beta-1 , TGF-beta 1 protein , latency-associated peptide , transforming growth factor, beta 1 (Camurati-Engelmann disease) , transforming growth factor-beta-1 , TGF-beta 1 , transforming growth factor-beta 1 , transforming growth factor, beta-1 , transforming growth factor beta 1 , regulatory protein , transforming growth factor-beta , TGF-beta-5 , tgf beta , tgf-beta 5 , transforming gorwth factor-Beta5 , transforming growth factor-B5 , transforming growth factor-beta 5 , Transforming growth factor beta-1

GENE ID SPECIES
574135 Macaca mulatta
359834 Danio rerio
768263 Felis catus
456060 Pan troglodytes
462081 Pan troglodytes
481519 Canis lupus familiaris
495971 Xenopus laevis
712503 Macaca mulatta
779782 Xenopus (Silurana) tropicalis
100227786 Taeniopygia guttata
100397340 Callithrix jacchus
100401979 Callithrix jacchus
100441300 Pongo abelii
100459982 Pongo abelii
100580274 Nomascus leucogenys
100581386 Nomascus leucogenys
100873157 Gallus gallus
7040 Homo sapiens
397078 Sus scrofa
443417 Ovis aries
59086 Rattus norvegicus
403998 Canis lupus familiaris
282089 Bos taurus
21803 Mus musculus
100008645 Oryctolagus cuniculus
100135628 Cavia porcellus
100033900 Equus caballus
397778 Xenopus laevis
100136774 Oncorhynchus mykiss
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