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Browse our VAV1 Proteins (VAV1)

Full name:
Vav 1 Oncogene Proteins (VAV1)
On are 5 Vav 1 Oncogene (VAV1) Proteins from 4 different suppliers available. Additionally we are shipping VAV1 Antibodies (138) and VAV1 Kits (5) and many more products for this protein. A total of 152 VAV1 products are currently listed.
Vav, vav-T
list all proteins Gene Name GeneID UniProt
VAV1 7409 P15498
Rat VAV1 VAV1 25156  
Mouse VAV1 VAV1 22324 P27870

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VAV1 Proteins (VAV1) by Origin

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More Proteins for VAV1 Interaction Partners

Human Vav 1 Oncogene (VAV1) interaction partners

  1. revealed a new function for Vav1 in the negative feedback regulation of the phosphorylation of immunoreceptor tyrosine-based activation motifs within the zeta chains, CD3 delta (show CD3D Proteins), epsilon, gamma chains, as well as activation sites on the critical T cell tyrosine kinases

  2. Data indicate that only a single mutation in the proto-oncogene (show RAB1A Proteins) Vav1 enhances tumorigenicity.

  3. These findings establish VAV1 as a critical epigenetically regulated oncogene (show RAB1A Proteins) with a key role in MBSHH maintenance, and highlight its potential as a validated therapeutic target and prognostic biomarker for the improved therapy of medulloblastoma.

  4. The present study implies that estrogen-estrogen receptor (show ESR1 Proteins) modulates the transcription and expression of Vav1, which may contribute to the proliferation of cancerous cells.

  5. The role of Vav1 in T leukemia survival by selectively triggering Rac2 (show RAC2 Proteins)-Akt (show AKT1 Proteins) axis and elevating the expression of anti-apoptotic Bcl-2 (show BCL2 Proteins).

  6. results presented herein suggest a potential cross-talk between cancer cells and the microenvironment controlled by CSF1 (show CSF1 Proteins)/Vav1 signaling pathways.

  7. our data provide evidence that Vav1 is the linker molecule that couples CD28 to PIP5Kalpha activation and strongly fit with a potential model in which CD28 regulates PIP2 synthesis and turnover in T lymphocytes.

  8. suggest that Vav1 promotes the matrix-degrading processes underlying tumor cell migration and further, under conditions of ectopic Vav1 expression, that Vav1 is a central regulator and major driver of invasive matrix remodeling by pancreatic tumor cells

  9. VAV1 overexpression in both SKOV3 and human ovarian surface epithelial cells demonstrated that its upregulation of an E-cadherin (show CDH1 Proteins) transcriptional repressor, Snail (show SNAI1 Proteins) and Slug (show SNAI2 Proteins), was not confined to ovarian cancer cells

  10. The results highlight for the first time the potential role of Vav1 as an oncogenic stress activator in cancer and the p53 (show TP53 Proteins) dependence of its pro-apoptotic effect in breast cells.

Mouse (Murine) Vav 1 Oncogene (VAV1) interaction partners

  1. provide evidence that CD28 (show CD28 Proteins) and the TCR complex regulate NF-kappaB (show NFKB1 Proteins) via different signaling modules of GRB-2 (show GRB2 Proteins)/VAV1 and LAT (show LAT Proteins)/ADAP (show APP Proteins) pathways respectively.

  2. Platelet P-Rex and Vav family Rac (show AKT1 Proteins)-GEFs play important proinflammatory roles in leukocyte recruitment.

  3. The data show that vav1 not only affects transcription of the MHCII locus but also is an important regulator of MHCII protein transport to the cell surface.

  4. analyses revealed a SHP2 (show PTPN11 Proteins)- and Lyn (show LYN Proteins)-dependent pathway leading to phosphorylation of Vav1, Rac (show AKT1 Proteins) activation, and F-actin polymerization in SCF (show KITLG Proteins)-treated BMMCs

  5. Data indicate that Vav1 was a key negative regulator of macrophage-derived IL-6 (show IL6 Proteins) production.

  6. Bruton's Tyrosine Kinase (BTK (show BTK Proteins)) and Vav1 contribute to Dectin1 (show CLEC7A Proteins)-dependent phagocytosis of Candida albicans in macrophages.

  7. Suggest that Vav1 act as critical molecular link coupling hyperlipidemia with proatherogenic monocyte/macrophage responses.

  8. Loss of Vav1 activity does not favour development of colitis-associated colon cancer.

  9. SH2 and SH3(B) domains of Vav1 are critical for the phosphorylation of Vav1 and its signalling function in TCR-induced calcium flux.

  10. SAP (show APCS Proteins) couples SLAM (show SLAMF1 Proteins) family receptors to the kinase Fyn (show FYN Proteins), which triggered the exchange factor Vav-1 and augmented NK cell activation.

VAV1 Protein Profile

Protein Summary

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with VAV1

  • vav 1 guanine nucleotide exchange factor (VAV1)
  • vav 1 guanine nucleotide exchange factor (Vav1)
  • vav 1 oncogene (Vav1)
  • vav 1 oncogene (vav1)
  • Vav protein
  • vav-T protein

Protein level used designations for Vav 1 Oncogene Proteins (VAV1)

vav 1 oncogene , proto-oncogene vav , p95 , p95vav , vav oncogene

455647 Pan troglodytes
7409 Homo sapiens
25156 Rattus norvegicus
485016 Canis lupus familiaris
617345 Bos taurus
100519821 Sus scrofa
22324 Mus musculus
446826 Xenopus laevis
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