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Data show although no any significant differences between patient groups and lean subjects of proteins SYT4 (show SYT4 ELISA Kits), BAG3 (show BAG3 ELISA Kits), APOA1 (show APOA1 ELISA Kits), and VAV3, except for VGF (show VGF ELISA Kits) protein, there was a trend between the expression of these four genes and their protein levels.
VAV3 overexpression is a novel biomarker for poor prognosis and survival in ovarian carcinoma.
VAV3 overexpression could be a useful marker for predicting the outcomes of CRC (show CALR ELISA Kits) patients and that VAV3 targeting represents a potential modality for treating CRC (show CALR ELISA Kits)
Inhibition of Vav3 could reverse the drug resistance of gastric cancer cells by downregulating JNK (show MAPK8 ELISA Kits) signaling pathway.
This study proposes VAV3 as a biomarker and a rationale for its use as a signaling target to prevent and/or overcome resistance to endocrine therapy in breast cancer.
A new genome-wide significant association between VAV3 and IgA nephropathy.
Data indicate that Vav3 oncogene (show RAB1A ELISA Kits) protein plays a crucial role in prostate cancer growth and malignant behavior, and could be a potential therapeutic target.
Vav3 is involved in the proliferation, migration, and invasion of gastric cancer cell as a tumor oncogene (show RAB1A ELISA Kits)
Interrupting Vav3 signaling enhances docetaxel-induced apoptosis in LNCaP cells under chronic hypoxia by inhibiting the PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits), ERK (show EPHB2 ELISA Kits), and AR signaling pathways.
VAV3 can be seen as novel candidate gene for schizophrenia in which both rare and common variants may be related to increased genetic risk in a Japanese population. rs1410403 might affect the volume of the left temporal gyri.
Vav3 is a regulator of retinal progenitor cell differentiation, thus highlighting a novel role for guanine nucleotide exchange factors in retinogenesis.
Platelet P-Rex and Vav (show VAV1 ELISA Kits) family Rac (show AKT1 ELISA Kits)-GEFs play important proinflammatory roles in leukocyte recruitment.
chow diet-fed Vav3 knockout mice develop an incomplete postreceptor insulin (show INS ELISA Kits) state characterized by typical liver and plasma metabolic syndrome-like pathophysiologies that is not associated to other defects such as white adipocyte hypertrophy and obesity
Data demonstrate that the co-expression of the exchange factors Vav2 (show VAV2 ELISA Kits) and Vav3 is critical for the development of this tumor type.
Vav2 (show VAV2 ELISA Kits) and Vav3 are required for normal peripheral nerve degeneration/regeneration, revascularization and functional recovery.
Vav3 collaborates with p190 (show CNTNAP1 ELISA Kits)-BCR-ABL (show ABL1 ELISA Kits) in lymphoid progenitor leukemogenesis, proliferation, and survival.
Dectin-1 (show CLEC7A ELISA Kits) activates the integrin Mac-1 (show ITGAM ELISA Kits) in neutrophils via Vav1 (show VAV1 ELISA Kits) and Vav3 signaling to promote Candida albicans clearance.
study discloses an essential and nonredundant role for this Vav (show VAV1 ELISA Kits) family member in axon guidance events in brainstem neurons that control blood pressure and respiratory rates
CD36 (show CD36 ELISA Kits) contributes to activation of Vav-1 (show VAV1 ELISA Kits), -2, and -3 in aortae from hyperlipidemic mice
Vav3 is a bona fide Ahr (show AHR ELISA Kits) target that is in charge of a limited subset of the developmental and physiological functions controlled by this transcriptional factor.
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
vav 3 oncogene
, guanine nucleotide exchange factor VAV3
, vav 3 protein