Browse our ZAP70 Proteins (ZAP70)

Full name:
zeta-Chain (TCR) Associated Protein Kinase 70kDa Proteins (ZAP70)
On are 11 zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) Proteins from 6 different suppliers available. Additionally we are shipping ZAP70 Antibodies (563) and ZAP70 Kits (20) and many more products for this protein. A total of 610 ZAP70 products are currently listed.
70kDa, AI327364, MGC80670, MGC88962, mrtle, mur, SRK, STCD, STD, TZK, ZAP-70, ZAP70
list all proteins Gene Name GeneID UniProt
Mouse ZAP70 ZAP70 22637 P43404
Rat ZAP70 ZAP70 301348  
ZAP70 7535 P43403

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ZAP70 Proteins (ZAP70) by Origin

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Mouse (Murine) zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) interaction partners

  1. disruption of normal Zap70 autoinhibition engaged negative feedback mechanisms by which negative selection and inhibitory receptors restrain TCR signaling to enforce both central and peripheral tolerance.

  2. in this study, authors discovered a cycle of recruitment, activation and release for Zap70 kinases at phosphorylated T-cell antigen receptors, which turned them into a 'catalytic unit' that amplified antigenic stimuli

  3. was significantly increased in 22-month AEW mice compared with 5-month AEW mice. ELISA data showed that secretions of IL-2 and NGF in 22-month AEW mice were higher than 5-month AEW mice. Our results indicate that increased ZAP70 is involved in dry skin in elderly pruritus. Increased secretion of IL-2 and NGF may induce dry skin itch.

  4. this study shows that ZAP-70 mutation has a strong impact on T cell-driven arthritis in SKG model regardless of the genetic background

  5. These findings establish Otud7b (show OTUD7B Proteins) as a positive regulator of T cell receptor-proximal signaling and T cell activation, highlighting the importance of deubiquitination in regulating Zap70 function.

  6. Data suggest that ring finger protein 41 Nrdp1 (show RNF41 Proteins) terminates T cell antigen receptors (TCRs) signaling by inactivating Zap70 kinase.

  7. Zap70 as a structural protein regulates integrin-mediated control of actin and with its catalytic activity regulates T cell receptor-mediated control of actin and membrane remodelling during formation of the immunological synapse.

  8. Blockade of CXCR7 suppressed MIF (show MIF Proteins)-mediated ERK (show EPHB2 Proteins)- and zeta-chain-associated protein kinase (show CDK7 Proteins) (ZAP)-70 activation

  9. mediates the CD4 (show CD4 Proteins) lineage differentiation in response to Class II selecting ligands

  10. In mice with spondylarthritis, microbiota content varied according to whether T cell receptor signal strength was normal or was impaired due to the ZAP-70(W163C) mutation.

Human zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) interaction partners

  1. ZAP-70 signaling was impaired by cholesterol depletion, further supporting the importance of membrane organization in TCR signaling.

  2. We conclude that ZAP70 plays a role for the homing to and/or the survival of ALL cells in the CNS and that ZAP70 may represent a therapeutic target. Furthermore, targeting CCR7 (show CCR7 Proteins)/CXCR4 (show CXCR4 Proteins) may be particularly promising in treating T-ALL.

  3. The aim of this study was to evaluate the expression of ZAP70 changing during disease progression, the intracellular interferon gamma (IFN-gamma (show IFNG Proteins)) and IL-4 (show IL4 Proteins) content of T and B lymphocytes and the CLL cell subset (CD5 (show CD5 Proteins)+CD19 (show CD19 Proteins)+) in CLL patients and healthy subjects, and ZAP70 correlation with cytokine production.

  4. in this study, authors discovered a cycle of recruitment, activation and release for Zap70 kinases at phosphorylated T-cell antigen receptors, which turned them into a 'catalytic unit' that amplified antigenic stimuli

  5. The histological observations suggested that the patients represent diverse cases of NHL like mature B-cell type, mature T-cell type and high grade diffuse B-cell type NHL. The findings indicate that patients with NHL may also be analyzed for status of PAX5, CD19 and ZAP70, and their transcriptional and post-translational variants for the differential diagnosis of NHL and therapy.

  6. Compound heterozygous mutations in ZAP70 gene is associated with leaky severe combined immunodeficiency (show PRKDC Proteins) disorder.

  7. The results suggest that genetic polymorphism in the 3' UTR of ZAP-70 is associated with rheumatoid arthritis susceptibility in southern Taiwanese.

  8. Cellular studies with ZAP70 showed that multiple lipids bind its C-terminal SH2 domain in a spatiotemporally specific manner and thereby exert exquisite spatiotemporal control over its protein binding and signaling activities in T cells.

  9. Whole-exome sequencing performed on five family members revealed two affected siblings to be compound heterozygous for two unique missense mutations in the 70-kD T cell receptor zeta-chain associated protein (ZAP-70).

  10. The data suggest that ZO-1 (show TJP1 Proteins), along with CD38 and Zap-70, plays a role in cell cycle regulation in chronic B cell leukemia, and may be used as a prognostic marker in the disease monitoring.

Cow (Bovine) zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) interaction partners

  1. The surface expression of CTLA-4 (show CTLA4 Proteins) was increased in subclinical stages of paratuberculosis infection while levels of ZAP-70 were decreased in CD4 (show CD4 Proteins)+ T cells of both subclinical and clinical animals, indicating a change in T cell phenotype with disease state.

ZAP70 Protein Profile

Protein Summary

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.

Alternative names and synonyms associated with ZAP70

  • zeta-chain (TCR) associated protein kinase 70kDa (zap70)
  • zeta-chain (TCR) associated protein kinase 70kDa (ZAP70)
  • tyrosine-protein kinase zap-70 (Smp_149470)
  • zeta-chain (TCR) associated protein kinase (Zap70)
  • zeta-chain (TCR) associated protein kinase 70 (Zap70)
  • zeta-chain (TCR) associated protein kinase 70kDa (Zap70)
  • 70kDa protein
  • AI327364 protein
  • MGC80670 protein
  • MGC88962 protein
  • mrtle protein
  • mur protein
  • SRK protein
  • STCD protein
  • STD protein
  • TZK protein
  • ZAP-70 protein
  • ZAP70 protein

Protein level used designations for ZAP70

zeta-chain (TCR) associated protein kinase 70kDa , zeta-chain associated protein kinase 70kDa , tyrosine-protein kinase zap-70 , tyrosine-protein kinase ZAP-70-like , 70 kDa zeta-associated protein , 70 kDa zeta-chain associated protein , syk-related tyrosine kinase , tyrosine-protein kinase ZAP-70 , syk-related protein tyrosine kinase , zeta-chain associated protein kinase, 70kD

446840 Xenopus laevis
448557 Xenopus (Silurana) tropicalis
459427 Pan troglodytes
707555 Macaca mulatta
8343736 Schistosoma mansoni
100342021 Oryctolagus cuniculus
100390922 Callithrix jacchus
100451782 Pongo abelii
100542877 Meleagris gallopavo
100589243 Nomascus leucogenys
22637 Mus musculus
301348 Rattus norvegicus
7535 Homo sapiens
100271860 Canis lupus familiaris
100524930 Sus scrofa
504509 Bos taurus
100713473 Cavia porcellus
420086 Gallus gallus
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