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These findings establish Otud7b (show OTUD7B Proteins) as a positive regulator of T cell receptor-proximal signaling and T cell activation, highlighting the importance of deubiquitination in regulating Zap70 function.
Data suggest that ring finger protein 41 Nrdp1 (show RNF41 Proteins) terminates T cell antigen receptors (TCRs) signaling by inactivating Zap70 kinase.
Zap70 as a structural protein regulates integrin-mediated control of actin and with its catalytic activity regulates T cell receptor-mediated control of actin and membrane remodelling during formation of the immunological synapse.
Blockade of CXCR7 suppressed MIF (show MIF Proteins)-mediated ERK (show EPHB2 Proteins)- and zeta-chain-associated protein kinase (show CDK7 Proteins) (ZAP)-70 activation
mediates the CD4 (show CD4 Proteins) lineage differentiation in response to Class II selecting ligands
In mice with spondylarthritis, microbiota content varied according to whether T cell receptor signal strength was normal or was impaired due to the ZAP-70(W163C) mutation.
expression of Zap70 protein was essential for both long-term survival of naive T cells and for their proliferation in response to lymphopenia.
ZAP-70 enhances the migration of malignant B-cells into the supportive microenvironment found in the bone marrow mainly by enhancing signaling and migration after CXCR4 (show CXCR4 Proteins) stimulation.
Titration of Zap70 activity resulted in graded reductions in positive and negative selection but did not decrease the cumulative TCR signals integrated by positively selected OT-I cells
MIF (show MIF Proteins) promotes the migration of B cells through a ZAP-70-dependent pathway mediated by cooperative engagement of CXCR4 (show CXCR4 Proteins) and CD74 (show CD74 Proteins).
Cellular studies with ZAP70 showed that multiple lipids bind its C-terminal SH2 domain in a spatiotemporally specific manner and thereby exert exquisite spatiotemporal control over its protein binding and signaling activities in T cells.
Whole-exome sequencing performed on five family members revealed two affected siblings to be compound heterozygous for two unique missense mutations in the 70-kD T cell receptor zeta-chain associated protein (ZAP-70).
The data suggest that ZO-1 (show TJP1 Proteins), along with CD38 and Zap-70, plays a role in cell cycle regulation in chronic B cell leukemia, and may be used as a prognostic marker in the disease monitoring.
A distinct set of proteins interaction partners required for chemokine (show CCL1 Proteins)-directed T cell migration is attracted by phosphotyrosine 571 of ADAP (show FYB Proteins), including ZAP70.
Activation of innate immune receptors induces an antiapoptotic signal and proliferation in ZAP-70-positive chronic lymphocytic leukemia dependent on Syk (show SYK Proteins) activation.
In all, our study demonstrates that miR (show MLXIP Proteins)-631 decreases PCa (show FLVCR1 Proteins) cell migration and invasion by dampening ZAP70 expression.
The differential requirements of ZAP70 and SYK (show SYK Proteins) during thymic development.
Blockade of CXCR7 suppressed MIF (show AMH Proteins)-mediated ERK (show EPHB2 Proteins)- and zeta-chain-associated protein kinase (show CDK7 Proteins) (ZAP)-70 activation
The kinase activity of ZAP-70 stimulates negative feedback pathways that target Lck (show LCK Proteins) and thereby modulate the phosphorylation patterns of the immunoreceptor tyrosine-based activation motifs of t cell receptors.
Low ZAP-70 expression is associated with B-cell chronic lymphoid leukemia.
The surface expression of CTLA-4 (show CTLA4 Proteins) was increased in subclinical stages of paratuberculosis infection while levels of ZAP-70 were decreased in CD4 (show CD4 Proteins)+ T cells of both subclinical and clinical animals, indicating a change in T cell phenotype with disease state.
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
zeta-chain (TCR) associated protein kinase 70kDa
, zeta-chain associated protein kinase 70kDa
, tyrosine-protein kinase zap-70
, tyrosine-protein kinase ZAP-70-like
, 70 kDa zeta-associated protein
, 70 kDa zeta-chain associated protein
, syk-related tyrosine kinase
, tyrosine-protein kinase ZAP-70
, syk-related protein tyrosine kinase
, zeta-chain associated protein kinase, 70kD