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Browse our FEN1 (FEN1) ELISA Kits

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Flap Structure-Specific Endonuclease 1 ELISA Kits (FEN1)
On are 5 Flap Structure-Specific Endonuclease 1 (FEN1) ELISA Kits from 1 different suppliers available. Additionally we are shipping FEN1 Antibodies (101) and FEN1 Proteins (55) and many more products for this protein. A total of 169 FEN1 products are currently listed.
AW538437, cb879, fen-1, fen1, mf1, rad2, xFEN1a
list all ELISA KIts Gene Name GeneID UniProt
FEN1 14156  
FEN1 2237 P39748
FEN1 84490 Q5XIP6

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More ELISA Kits for FEN1 Interaction Partners

Arabidopsis thaliana Flap Structure-Specific Endonuclease 1 (FEN1) interaction partners

  1. Data show that shade avoidance 6 (SAV6; At5g26680), encodes flap endonuclease-1 (FEN1), assures proper root development through maintenance of genome integrity.

Mouse (Murine) Flap Structure-Specific Endonuclease 1 (FEN1) interaction partners

  1. WDR4 (show WDR4 ELISA Kits) regulates FEN1's potential DNA cleavage threat near the site of replication.

  2. The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers.

  3. PARP1 (show PARP1 ELISA Kits) is required for FEN1 recruitment to DNA repair intermediates in base excision repair.

  4. FFAA Fen1 mutation causes defective Pcna (show PCNA ELISA Kits) -coordinated Okazaki fragment maturation.

  5. A point mutation in the base excision repair gene flap endonuclease 1 causes a functional deficiency in repairing base damage, such that individuals carrying the mutation or similar mutations are predisposed to chemical-induced cancer development.

  6. FEN1 localization within the mitochondrial compartment of mouse brain tissue

  7. Distinct roles for two Mg2 (show MCOLN1 ELISA Kits)+ binding sites in the regulation of FEN-1 nuclease (show DCLRE1C ELISA Kits) activities include enhancement of DNA substrate binding ability and modulation of conformational changes.

  8. FEN1 has roles in DNA repair, as well as in DNA replication

  9. Fen1 is induced independently in mouse embryonic fibroblasts by ultraviolet (UV-C)light

  10. These data demonstrate the importance of the FEN-1/PCNA (show PCNA ELISA Kits) complex in DNA replication and in the embryonic development of mice.

Human Flap Structure-Specific Endonuclease 1 (FEN1) interaction partners

  1. Binding of DNA to human FEN1 in a bent conformation occurred independently of 5'-flap (show ALOX5AP ELISA Kits) accommodation and did not require active site metal ions or the presence of conserved active site residues.

  2. In this study, we found that cohesion establishment factors, like CHlR1, cooperatively stimulate endonuclease activity of hFen1 in in vivo mimic condition, including replication protein-A-coated DNA and high salt.

  3. Under DNA repair conditions, FEN1 efficiently repaired the 5'-phoshotyrosyl bond-containing SSB substrates in the presence of DNA ligase and DNA polymerase (show POLB ELISA Kits).

  4. WDR4 (show WDR4 ELISA Kits) regulates FEN1's potential DNA cleavage threat near the site of replication.

  5. Patients with expression of both FEN1 and RAD54B (show RAD54B ELISA Kits) were prone to have advanced nodal involvement and significantly poor prognosis.

  6. Fen1 significantly stimulated trinucleotide repeats expansion by Pol beta (show POLB ELISA Kits), but not by the related enzyme Pol lambda (show POLL ELISA Kits).

  7. YY1 (show YY1 ELISA Kits) is a transcription repressor of FEN1 regulating FEN1 levels in response to DNA damaging agents.

  8. EXO1 (show EXO1 ELISA Kits) and FEN1 cleaved the substrate at the boundary between the single-stranded 5' flap (show ALOX5AP ELISA Kits) and the duplex, whereas FAN1 (show FSCN1 ELISA Kits) incised it three to four nucleotides in the double-stranded region.

  9. Rate-determining step of FEN1 reflects a kinetic bias against long flaps and trinucleotide repeat sequences.

  10. FEN1 -69G>A and 4150G>T polymorphisms may be associated with cancer susceptibility in Chinese population.

FEN1 Antigen Profile

Antigen Summary

The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.

Alternative names and synonyms associated with FEN1

  • flap structure-specific endonuclease 1 (FEN1) Elisa Kit
  • flap endonuclease 1-like (LOC100808044) Elisa Kit
  • Flap endonuclease-1 (Bm1_49605) Elisa Kit
  • flap endonuclease-1 (AT5G26680) Elisa Kit
  • flap structure specific endonuclease 1 (Fen1) Elisa Kit
  • flap structure-specific endonuclease 1 (fen1) Elisa Kit
  • flap structure-specific endonuclease 1 (fen1-a) Elisa Kit
  • flap structure-specific endonuclease 1 (Fen1) Elisa Kit
  • nuclease, Rad2 family (FEN1) Elisa Kit
  • AW538437 Elisa Kit
  • cb879 Elisa Kit
  • fen-1 Elisa Kit
  • fen1 Elisa Kit
  • mf1 Elisa Kit
  • rad2 Elisa Kit
  • xFEN1a Elisa Kit

Protein level used designations for FEN1

flap endonuclease 1 , Flap structure-specific endonuclease 1 , flap structure-specific endonuclease 1 , DNase IV , maturation factor 1 , maturation factor-1 , 5' nuclease xFEN1a , FEN-1-A , flap endonuclease 1-A , flap structure-specific endonuclease 1-A , xFEN-1a , FEN-1

100059838 Equus caballus
100808044 Glycine max
6104806 Brugia malayi
832721 Arabidopsis thaliana
14156 Mus musculus
2237 Homo sapiens
386707 Danio rerio
394303 Xenopus laevis
769677 Gallus gallus
476063 Canis lupus familiaris
616242 Bos taurus
84490 Rattus norvegicus
100307042 Ovis aries
5721250 Chlamydomonas reinhardtii
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