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RNF20 (show RNF20 Proteins) and H2Bub1 promotes chronic colonic inflammation and inflammation-associated colorectal cancer in mice and humans, partly by augmenting NF-kappaB (show NFKB1 Proteins) activity and attenuating the antitumoral T cell response.
RNF20-mediated H2B ubiquitination at DSBs plays a critical role in HRR through chromatin remodeling
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails\; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.
H2B histone family, member F
, histone 1, H2bb
, histone H2B type 1-B
, histone H2B.1
, histone H2B.f