Browse our PAK1IP1 Proteins (PAK1IP1)

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PAK1 Interacting Protein 1 Proteins (PAK1IP1)
On are 5 PAK1 Interacting Protein 1 (PAK1IP1) Proteins from 3 different suppliers available. Additionally we are shipping PAK1IP1 Antibodies (26) and many more products for this protein. A total of 34 PAK1IP1 products are currently listed.
5830431I15Rik, 5930415H02Rik, AA419825, AI314040, AW556169, bA421M1.5, fb11d05, Gdpd1, hPIP1, MAK11, PAK1IP1, PIP1, PTOP, RP11-421M1.5, TINT1, TPP1, WDR84, wu:fb11d05, zgc:56683
list all proteins Gene Name GeneID UniProt
Rat PAK1IP1 PAK1IP1 361232  
PAK1IP1 65057 Q96AP0
PAK1IP1 68083 Q9DCE5

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PAK1IP1 Proteins (PAK1IP1) by Origin

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More Proteins for PAK1IP1 Interaction Partners

Human PAK1 Interacting Protein 1 (PAK1IP1) interaction partners

  1. a novel ACD (show ACD Proteins) mutation(p.G223V)is detected; ACD (show ACD Proteins) is a novel gene involved in childhood pre-B acute lymphoblastic leukemia and may play a functional role in enhancing leukemia cell survival

  2. The data support a causal relationship between a TPP1 (show TPP1 Proteins) mutation and bone marrow disorders in a family.

  3. Clustering of novel mutations in the POT1 (show POT1 Proteins) binding domain of ACD (show ACD Proteins) was statistically higher (P = .005) in melanoma probands compared with population control individuals (n = 6785).

  4. Shelterin protein TPP 1 (show TPP1 Proteins) interacts with hTERT and recruits hTERT onto the telomeres, suggesting that TPP 1 (show TPP1 Proteins) might be involved in regulation of telomere shortening.

  5. A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting.

  6. POT1 (show POT1 Proteins)-TPP1 (show TPP1 Proteins) binds telomeric DNA in a coordinated manner to facilitate assembly of the nucleoprotein complexes into a state that is more accessible to enzymatic activity.

  7. Study shows that the OB-fold domain of the telomere-binding protein TPP1 (show TPP1 Proteins) recruits telomerase to telomeres through an association with the telomerase reverse transcriptase TERT (show TERT Proteins); data define a potential interface for telomerase-TPP1 (show TPP1 Proteins) interaction required for telomere maintenance and implicate defective telomerase recruitment in telomerase-related disease.

  8. a paper that firstly reported cloning of human TTP1 (show COPRS Proteins) (PTOP) and its biological function at telomere. TPP1 (show TPP1 Proteins) interacts with both POT1 (show POT1 Proteins) and TIN2 (show TINF2 Proteins), heterodimerizes with POT1 (show POT1 Proteins) and regulates POT1 (show POT1 Proteins) telomeric recruitment and telomere length.

  9. The presence of dysfunctional telomeres in chronic lymphocytic leukemia did not correlate with telomere shortening or chromatin marks deregulation but with a down-regulation of 2 shelterin genes: ACD (show ACD Proteins) and TINF2 (show TINF2 Proteins).

  10. Results support a model in which POT1 (show POT1 Proteins)-TPP1 (show TPP1 Proteins) enhances telomerase processivity in a manner markedly different from the sliding clamps used by DNA polymerases.

Mouse (Murine) PAK1 Interacting Protein 1 (PAK1IP1) interaction partners

  1. A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting.

  2. Results suggest that the PAK-PIX-GIT1 complex is critical for Erk-dependent myosin phosphorylation and vascular permeability.

PAK1IP1 Protein Profile

Protein Summary

This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I.

Alternative names and synonyms associated with PAK1IP1

  • PAK1 interacting protein 1 (Pak1ip1)
  • PAK1 interacting protein 1 (PAK1IP1)
  • PAK1 interacting protein 1 (pak1ip1)
  • PAK1 interacting protein 1 (LOC100357229)
  • adrenocortical dysplasia homolog (mouse) (ACD)
  • 5830431I15Rik protein
  • 5930415H02Rik protein
  • AA419825 protein
  • AI314040 protein
  • AW556169 protein
  • bA421M1.5 protein
  • fb11d05 protein
  • Gdpd1 protein
  • hPIP1 protein
  • MAK11 protein
  • PAK1IP1 protein
  • PIP1 protein
  • PTOP protein
  • RP11-421M1.5 protein
  • TINT1 protein
  • TPP1 protein
  • WDR84 protein
  • wu:fb11d05 protein
  • zgc:56683 protein

Protein level used designations for PAK1IP1

PAK1 interacting protein 1 , rp11-421m1.5 , p21-activated protein kinase-interacting protein 1-like , POT1 and TIN2 organizing protein , POT1 and TIN2-interacting protein , TIN2 interacting protein 1 , adrenocortical dysplasia protein homolog , PAK/PLC-interacting protein 1 , PAK1-interacting protein 1 , WD repeat-containing protein 84 , p21-activated protein kinase-interacting protein 1 , glycerophosphodiester phosphodiesterase domain containing 1 , putative PAK inhibitor Skb15

361232 Rattus norvegicus
463143 Pan troglodytes
478719 Canis lupus familiaris
549808 Xenopus (Silurana) tropicalis
697856 Macaca mulatta
100051197 Equus caballus
100357229 Oryctolagus cuniculus
100397878 Callithrix jacchus
100468656 Ailuropoda melanoleuca
100602729 Nomascus leucogenys
65057 Homo sapiens
55003 Homo sapiens
68083 Mus musculus
505125 Bos taurus
420850 Gallus gallus
336470 Danio rerio
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