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Replication Protein A1, 70kDa Proteins (RPA1)
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Synonyms:
70kDa, 5031405K23Rik, AA589576, AW557552, Cb1-727, CG9633, D-RPA70, D-SSB, Dmel\\CG9633, DmRPA, dmrpa1, dRP-A, HSSB, i164, LOC100230990, MST075, Mt-SSB, MtSSB, REPA1, RF-A, rp-a, Rpa, Rpa-70, RPA1, rpa70, RPA 70, RPA 70 kDa, Ssb-70, Ssbp1, wu:fi14b08, zgc:55337, zgc:77092
list all proteins Gene Name GeneID UniProt
RPA1 68275 Q8VEE4
Rat RPA1 RPA1 287524  
RPA1 6117 P27694

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Replication Protein A1, 70kDa Proteins (RPA1) by Origin

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More Proteins for Replication Protein A1, 70kDa Interaction Partners

Fruit Fly (Drosophila melanogaster) Replication Protein A1, 70kDa (RPA1) interaction partners

  1. loss-of-function alleles indicate that RPA is required to prevent neuroepithelial cells from differentiating into medulla neuroblasts

  2. Data show that the basic cleft of the RPA70 N-terminal OB-fold domain binds multiple checkpoint proteins, including RAD9, to promote ATR signaling.

Mouse (Murine) Replication Protein A1, 70kDa (RPA1) interaction partners

  1. The authors establish that a second Dna2-Rpa interaction is mutually exclusive with Rpa-DNA interactions and mediates the displacement of Rpa from ssDNA.

  2. LT prevents recruitment of RPA to nuclear foci after DNA damage. This leads to failure to recruit repair proteins such as Rad51 (show RAD51 Proteins) or Rad9 (show RAD9A Proteins), explaining why LT prevents repair of double strand DNA breaks by homologous recombination.

  3. Most RPA recruitment during class switch recombination represents salvage of unrepaired breaks by homology-based pathways during the S-G2 (show STRN3 Proteins)/M phase of the cell cycle.

  4. POT1a (show POT1 Proteins) degradation resulted in rapid and reversible activation of the ATR pathway in G1 and S/G2 (show STRN3 Proteins).

  5. Rpa1(L230P) missense mutation significantly alters the tumor phenotype and spectrum of Trp53 (show TP53 Proteins) mutant mice by modifying the genetic mechanisms underlying tumorigenesis.

  6. both TNFR-p55 (show TNFRSF1A Proteins) and TNFR (show TNFRSF1A Proteins)-p75 (show NGFR Proteins) appear to be of minimal importance for modulation of Fas (show FAS Proteins)-mediated apoptosis and associated A1 protein expression despite normal Fas (show FAS Proteins)/TNFR-p55 (show TNFRSF1A Proteins) and increased TNFR (show TNFRSF1A Proteins)-p75 (show NGFR Proteins) expression in neutrophils

  7. Rpa1 functions in DNA metabolism are essential for the maintenance of chromosomal stability and tumor suppression.

  8. hyperphosphorylation may play a role in modulating cellular pathways by altering the DNA binding domain-mediated RPA-DNA and RPA-protein interactions, hypothetically via the interaction of hyperphosphorylated RPA32N with DBD-B

  9. These results demonstrate that neither RPA hyper-phosphorylation nor H2AX are required for the formation in RPA intra-nuclear foci in response to DNA damage/replicational stress.

Human Replication Protein A1, 70kDa (RPA1) interaction partners

  1. RPA is a sensor of R loops and a regulator of RNaseH1, extending the versatile role of RPA in suppression of genomic instability.

  2. Annealing helicase HARP closes RPA-stabilized DNA bubbles non-processively.

  3. Architectural plasticity of human BRCA2 (show BRCA2 Proteins)-RPA-RAD51 (show RAD51 Proteins) complexes in DNA break repair has been described.

  4. Results suggest that the UNG2 N-terminus may serve as a flexible scaffold to tether PCNA and RPA at the replication fork, and that post-translational modifications on the UNG2 N-terminus disrupt formation of the PCNA-UNG2-RPA protein complex.

  5. Data suggest RAD52 (show RAD52 Proteins) binds tightly to RPA/ssDNA complex in presynaptic complex and inhibits RPA turnover; during presynaptic complex assembly, most of RPA and RAD52 (show RAD52 Proteins) is displaced from ssDNA, but some RAD52 (show RAD52 Proteins)/RPA/ssDNA complexes persist as interspersed clusters surrounded by RAD51 (show RAD51 Proteins) filaments. (RAD52 (show RAD52 Proteins) = Rad52 (show RAD52 Proteins) DNA repair/recombination protein (show RAD50 Proteins); RPA = replication protein A (show GPR153 Proteins); ssDNA = single-stranded DNA; RAD51 (show RAD51 Proteins) = Rad51 (show RAD51 Proteins) recombinase (show RAG1 Proteins))

  6. Data suggest that, during human DNA replication, restricting PCNA (proliferating cell nuclear antigen (show PCNA Proteins)) to the vicinity of its DNA target site is important; PCNA (show PCNA Proteins) can be maintained at or near primer/template junctions during DNA synthesis by RPA (replication protein A (show GPR153 Proteins)) or SSB (single-stranded DNA-binding protein); here, the SSB used was from Escherichia coli.

  7. Strikingly, the addition of the single-stranded DNA (ssDNA)-binding replication protein A (RPA) selectively restores XPF-ERCC1 endonuclease activity on this structure. The 5'-3' exonuclease SNM1A can load from the XPF-ERCC1-RPA-induced incisions and digest past the crosslink to quantitatively complete the unhooking reaction.

  8. The authors have discovered a major sub-pathway of conventional long-patch base excision repair that involves formation of a 9-nucleotide gap 5' to the lesion. This new sub-pathway is mediated by RECQ1 (show RECQL Proteins) DNA helicase and ERCC1 (show ERCC1 Proteins)-XPF endonuclease in cooperation with PARP1 poly(ADP-ribose) polymerase (show PARP1 Proteins) and RPA.

  9. RPA deficiency induces activation of the Fanconi anemia pathway in an ATR-dependent manner, which may play a role in the genome maintenance.

  10. Force regulated dynamics of RPA1 on a DNA fork during DNA replication has been reported.

Xenopus laevis Replication Protein A1, 70kDa (RPA1) interaction partners

  1. This study found that the N-terminus of the RPA large subunit interacts with both WRN and DNA2 and is essential for stimulating WRN's 3'->5' helicase activity and DNA2's 5'->3' ss-DNA exonuclease (show EXO1 Proteins) activity.

  2. The results provide strong biochemical evidence to link RPA to a specific DSB repair pathway and reveal a novel function of RPA in the generation of 3' ss-DNA for homology-dependent DSB repair.

  3. Replication protein A (show GPR153 Proteins) accumulated increasingly on replication-arrested chromatin.

  4. RPA1 subunit may directly recognize and bind to the 5-formyluracil on the single-stranded DNA.

Replication Protein A1, 70kDa (RPA1) Protein Profile

Protein Summary

Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair\; it does not support chromosomal DNA replication and cell cycle progression through S- phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange. Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.

Alternative names and synonyms associated with Replication Protein A1, 70kDa (RPA1)

  • Replication Protein A 70 (RpA-70)
  • replication protein A1, 70kDa (RPA1)
  • replication protein A1, 70kDa (rpa1)
  • replication protein A1, 70kDa (LOC100230990)
  • replication protein A1 (LOC100341460)
  • replication protein A1 (Rpa1)
  • replication protein A1 (rpa1)
  • Sjogren syndrome antigen B (autoantigen La) (SSB)
  • uncharacterized LOC100298705 (LOC100298705)
  • 70kDa protein
  • 5031405K23Rik protein
  • AA589576 protein
  • AW557552 protein
  • Cb1-727 protein
  • CG9633 protein
  • D-RPA70 protein
  • D-SSB protein
  • Dmel\\CG9633 protein
  • DmRPA protein
  • dmrpa1 protein
  • dRP-A protein
  • HSSB protein
  • i164 protein
  • LOC100230990 protein
  • MST075 protein
  • Mt-SSB protein
  • MtSSB protein
  • REPA1 protein
  • RF-A protein
  • rp-a protein
  • Rpa protein
  • Rpa-70 protein
  • RPA1 protein
  • rpa70 protein
  • RPA 70 protein
  • RPA 70 kDa protein
  • Ssb-70 protein
  • Ssbp1 protein
  • wu:fi14b08 protein
  • zgc:55337 protein
  • zgc:77092 protein

Protein level used designations for RPA1

CG9633-PA , RpA-70-PA , drosophila replication protein A , replication protein A 70 , single stranded-binding protein 70 , replication protein A1, 70kDa , replication protein A 70 kDa DNA-binding subunit , RF-A protein 1 , RP-A p70 , replication factor A protein 1 , replication protein A1 , replication protein A 70 kDa DNA-binding subunit-like , MSTP075 , single-stranded DNA-binding protein , replication protein A (RPA) , single-stranded DNA binding , single-stranded DNA-binding protein, mitochondrial

GENE ID SPECIES
40972 Drosophila melanogaster
454414 Pan troglodytes
491196 Canis lupus familiaris
504844 Bos taurus
548449 Xenopus (Silurana) tropicalis
100230990 Taeniopygia guttata
100302100 Ovis aries
100341460 Oryctolagus cuniculus
100402829 Callithrix jacchus
100481495 Ailuropoda melanoleuca
100525428 Sus scrofa
100585556 Nomascus leucogenys
68275 Mus musculus
287524 Rattus norvegicus
327491 Danio rerio
6117 Homo sapiens
417563 Gallus gallus
397937 Xenopus laevis
100173266 Pongo abelii
100008866 Oryctolagus cuniculus
100298705 Bos taurus
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