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The interaction of MDC1 with RNF8 (show RNF8 Proteins), but not with ATM (show ATM Proteins) requires WRAP53beta, suggesting that WRAP53beta facilitates the former interaction without altering phosphorylation of MDC1 by ATM (show ATM Proteins).
the sub-cellular localization of the WRAP53 protein has a significant impact on breast cancer survival.
This study showed that UCA1 and WRAP53 upregulation may serve as novel serum biomarkers for hepatocellular carcinoma diagnosis and prognosis.
WRAP53 is associated with development and progression of esophageal squamous cell carcinoma
Decreasing the expression of WRAP53 using RNA interference technique can enhance the radiosensitivity.
The telomerase holoenzyme Cajal body-associated protein, TCAB1, was released from telomerase RNA in mitotic cells coincident with TCAB1 delocalization from Cajal bodies.
The data indicated that TCAB1 might facilitate the occurrence and development of head and neck carcinomas.
Studied the association of a frequent genetic variation in WRAP53, rs2287499 (C/G), with breast cancer risk and prognosis among Iranian-Azeri population.
Study finds that TRiC (show MARVELD2 Proteins) is required for folding the telomerase cofactor TCAB1, which controls trafficking of telomerase and small Cajal body RNAs (scaRNAs).
SNPs in WRAP53 (rs2287497 and rs2287498) have stronger association with an ovarian cancer risk than rs1042522 in TP53 (show TP53 Proteins).
This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene.
WD repeat-containing protein 79
, WD40 protein Wrap53
, WD40 repeat-containing protein encoding RNA antisense to p53
, telomerase Cajal body protein 1
, WD repeat domain 79
, WD40 repeat-containing protein encoded by RNA antisense to p53
, WD repeat containing, antisense to TP53