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PEGylated lipoplexes were well tolerated by both HEK293 (ASGP (show MUC4 Proteins)-R-negative) and HepG2 (ASGP (show MUC4 Proteins)-R-positive) cell lines and delivered DNA to the hepatoma cell line HepG2 by ASGP (show MUC4 Proteins)-R mediation at levels three-fold greater than nonPEGylated lipoplexes.
findings show that the hepatitis E virus (HEV) ORF2 protein interacts directly with the ectodomain of both ASGR1 and ASGR2; ASGPR is involved in and facilitates HEV infection by binding to ORF2
the distribution of ASGR (show ASGR1 Proteins) in human testis, was investigated.
sH2a (show SH2D4A Proteins) has the potential to be a uniquely sensitive and specific novel marker for liver fibrosis and function.
found that the asialoglycoprotein receptor (ASGPR (show ASGR1 Proteins)) is involved in hepatocyte recognition of cells predestined for killing, including activated autologous T lymphocytes
The minor subunit splice variants, H2b and H2c, of the human asialoglycoprotein receptor are present with the major subunit H1 in different hetero-oligomeric receptor complexes
trafficks intracellularly and forms homo-oligomers, but does not bind asialo-orosomucoid (show ORM1 Proteins)
primary renal proximal tubular epithelial cells have a functional ASGPR (show ASGR1 Proteins), consisting of the H1 and H2 subunits, that is capable of specific ligand binding and uptake
the key roles of the ManR and ASGR (show ASGR1 Proteins) in controlling circulating levels of numerous glycoproteins critical for regulating reproductive hormones and blood coagulation.
The Ashwell receptor is composed of type 2 transmembrane glycoproteins termed Asgr1 (show ASGR1 Proteins) and Asgr2. Both are predominantly expressed in the liver.
ASGP-R2 mediates the clearance of glycoproteins that bear oligosaccharides terminating with Siaalpha2,6Gal and thereby helps maintain the relative concentrations of these glycoproteins in the blood.
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
asialoglycoprotein receptor 2
, C-type lectin domain family 4 member H2
, HBxAg-binding protein
, hepatic lectin H2
, ASGP-R 2
, ASGPR 2
, hepatic lectin 2
, hepatic lectin 2 RHL2
, hepatic lectin 2, RHL2
, hepatic lectin R2/3