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Browse our ATF4 Proteins (ATF4)

Full name:
Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) Proteins (ATF4)
On are 16 Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) Proteins from 7 different suppliers available. Additionally we are shipping ATF4 Antibodies (276) and ATF4 Kits (15) and many more products for this protein. A total of 327 ATF4 products are currently listed.
Atf-4, ATF4, ATF4C, C/ATF, CREB-2, CREB2, sb:eu681, TAXREB67, TXREB, wu:fb08f07, wu:fj01c08, wu:fk30b04, zgc:85951, zgc:171702
list all proteins Gene Name GeneID UniProt
ATF4 468 P18848
ATF4 11911 Q06507
ATF4 79255 Q9ES19

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ATF4 Proteins (ATF4) by Origin

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Top referenced ATF4 Proteins

  1. Human ATF4 Protein expressed in Escherichia coli (E. coli) - ABIN667937 : Hoeffler, Meyer, Yun, Jameson, Habener: Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA. in Science (New York, N.Y.) 1989 (PubMed)
    Show all 2 references for ABIN667937

  2. Human ATF4 Protein expressed in Wheat germ - ABIN1345933 : Zhang, Khachigian et al.: Injury-induced platelet-derived growth factor receptor-alpha expression mediated by interleukin-1beta (IL-1beta) release and cooperative transactivation by NF-kappaB and ATF-4: IL-1beta facilitates ... in The Journal of biological chemistry 2009 (PubMed)

More Proteins for ATF4 Interaction Partners

Xenopus laevis Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) interaction partners

  1. Over-expression of atf4 in embryos interferes with neurogenesis and eye formation.

  2. Unlike other CREB2 (ATF4) proteins, the ATF4 isolated from the gonads of Xenopus embryos contains a consensus phosphorylation site for protein kinase A (PKA).

Human Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) interaction partners

  1. There was decreased or loss of ATF4 in 52% of medullary thyroid cancer (MTC) (show RET Proteins)tumors (n = 39) compared with normal thyroid follicle cells. A negative correlation was observed between RET and ATF4 protein levels in MTC tumors.

  2. hypoxia-induced ATF4 expression may promote progression of proliferating infantile hemangioma through macrophage colony-stimulating factor (show CSF2 Proteins) induced M2-polarized macrophages infiltration.

  3. overexpression of eIF5 (show EIF5 Proteins) and 5MP induces translation of ATF4.

  4. ATF4 may exert various physiological roles in lipid metabolism depending on the nutrient composition. In addition, these results suggested that ATF4 has a role in regulating lipogenesis and in the development of NAFLD; thus ATF4 may be considered a therapeutic target for NAFLD.

  5. PERK (show EIF2AK3 Proteins)-eIF2alpha (show EIF2A Proteins)-ATF4 signaling pathway mediated by endoplasmic reticulum stress involved in osteoblast differentiation of periodontal ligament cells under cyclic mechanical force.

  6. The localization of ATF4 in the granular component of nucleoli together with its association with nascent RNA transcripts in cells undergoing proteotoxic cell stress could suggest a new function for ATF4 in cell stress management.

  7. The results showed that the FGF21 (show FGF21 Proteins) promoter contains three response elements for ATF4, suggesting that FGF21 (show FGF21 Proteins) is a sensitive target of ATF4.

  8. ADM-2 (show ADM2 Proteins) is a stress-inducible gene controlled by ATF-4.

  9. The results suggest that C12orf39, CSTA (show CSTA Proteins), and CALCB (show CALCB Proteins) are novel ATF4 target genes, and that C12orf39 promoter activity is activated by ATF4 through amino acid response element.

  10. High ATF4 expression is associated with osteosarcoma progression.

Mouse (Murine) Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) interaction partners

  1. Augmented ATF4 signals during retinal degeneration plays a cytotoxic role by triggering photoreceptor cell death.

  2. ATF4 might inhibit the transcription of Srebp1c (show SREBF1 Proteins) through TRB3 (show TRIB3 Proteins), which is repressed by IBMX and DEX during early adipogenesis

  3. ATF4 activates a negative-feedback loop, leading to the downregulation of RET (show RET Proteins) expression while upregulating expression of proapoptotic genes.

  4. Data demonstrate a novel function of ATF4 in agouti-related peptide neurons of the hypothalamus in energy balance and lipid metabolism.

  5. these results identify the ATF4-TRB3 (show TRIB3 Proteins)-AMPK (show PRKAA1 Proteins) axis as a novel pathway responsible for ethanol-induced liver steatosis.

  6. arsenic trioxide -mediated apoptosis is regulated by both endoplasmic reticulum and mitochondria events that are facilitated by ATF4 and the unfolded protein response

  7. Findings indicate that PERK (show EIF2AK3 Proteins) kinase-activating transcription factor 4 (ATF4) pathway affected the efficiency of X-box binding protein 1 (XBP1 (show XBP1 Proteins)) mRNA splicing by regulating inositol-requiring enzyme 1alpha (IRE1alpha (show ERN1 Proteins)) expression.

  8. Interference with DOT1L (show DOT1L Proteins) activity resulted in transcriptional activation of Atf4 and Ddit3 (show DDIT3 Proteins) accompanied by decreased levels of H3K79 dimethylation.

  9. results suggest that by inducing an atypical ISR and p53 (show TP53 Proteins)-independent apoptosis, ONC201 has clinical potential in hematological malignancies.

  10. TFEB (show TFEB Proteins)-regulated signaling pathway for osteoblast differentiation is involved in ATF4/CHOP (show DDIT3 Proteins)-dependent signaling pathway.

Pig (Porcine) Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) interaction partners

  1. expression levels of porcine ATF4 gene were up-regulated 60 days and 120 days after birth in both breeds and the expression level in Meishan pigs was obviously higher than that in Large White pigs

  2. Tissue transcription analysis revealed that both porcine CREB2 (show ATF2 Proteins) and CREB3 (show CREB3 Proteins) mRNA were ubiquitously detected in all examined tissues.

ATF4 Protein Profile

Protein Summary

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication.

Alternative names and synonyms associated with ATF4

  • activating transcription factor 4 (tax-responsive enhancer element B67) (ATF4)
  • activating transcription factor 4 (atf4-a)
  • activating transcription factor 4b1 (tax-responsive enhancer element B67) (atf4b1)
  • activating transcription factor 4 (atf4)
  • activating transcription factor 4b2 (atf4b2)
  • activating transcription factor 4 (ATF4)
  • activating transcription factor 4 (Atf4)
  • Atf-4 protein
  • ATF4 protein
  • ATF4C protein
  • C/ATF protein
  • CREB-2 protein
  • CREB2 protein
  • sb:eu681 protein
  • TAXREB67 protein
  • TXREB protein
  • wu:fb08f07 protein
  • wu:fj01c08 protein
  • wu:fk30b04 protein
  • zgc:85951 protein
  • zgc:171702 protein

Protein level used designations for ATF4

cyclic AMP-dependent transcription factor ATF-4 , activating transcription factor 4 (tax-responsive enhancer element B67) , cAMP-dependent transcription factor ATF-4 , activating transcription factor 4C , activating transcription factor 4 , DNA-binding protein TAXREB67 , cAMP response element-binding protein 2 , cAMP-responsive element-binding protein 2 , cyclic AMP-responsive element-binding protein 2 , tax-responsive enhancer element B67 , tax-responsive enhancer element-binding protein 67 , c/EBP-related ATF , tax-responsive enhancer element-binding protein 67 homolog , taxREB67 homolog , activating transcription factor ATF-4 , rATF-4

395693 Gallus gallus
398804 Xenopus laevis
406514 Danio rerio
448005 Xenopus (Silurana) tropicalis
468334 Pan troglodytes
556410 Danio rerio
703965 Macaca mulatta
744513 Pan troglodytes
100216465 Ovis aries
468 Homo sapiens
11911 Mus musculus
79255 Rattus norvegicus
100732296 Cavia porcellus
474503 Canis lupus familiaris
100144302 Sus scrofa
509107 Bos taurus
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