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Browse our ATP1A1 Proteins (ATP1A1)

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ATPase, Na+/K+ Transporting, alpha 1 Polypeptide Proteins (ATP1A1)
On are 9 ATPase, Na+/K+ Transporting, alpha 1 Polypeptide (ATP1A1) Proteins from 3 different suppliers available. Additionally we are shipping ATP1A1 Antibodies (123) and ATP1A1 Kits (26) and many more products for this protein. A total of 165 ATP1A1 products are currently listed.
atp1a1, atp1a1a.1, Atpa-1, BC010319, K-ATPase, Na+K+ATPase, Nkaa1b
list all proteins Gene Name GeneID UniProt
ATP1A1 476 P05023
Rat ATP1A1 ATP1A1 24211 P06685
ATP1A1 11928 Q8VDN2

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ATP1A1 Proteins (ATP1A1) by Origin

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More Proteins for ATP1A1 Interaction Partners

Human ATPase, Na+/K+ Transporting, alpha 1 Polypeptide (ATP1A1) interaction partners

  1. Data show that the expression of aquaporin (AQP) 1, AQP3, AQP5, epithelial Na+ channel (ENaC) and sodium potassium ATPase (Na-K-ATPase) are altered in patients with acute respiratory failure (ARF) due to diffuse alveolar damage (DAD), and the cause of DAD does not seem to influence the level of impairment of these channels.

  2. Ouabain stimulates NKA (show TAC1 Proteins) in renal proximal tubule cells through an angiotensin/AT1R (show AGTR1 Proteins)-dependent mechanism and that this pathway contributes to cardiac glycoside associated hypertension.

  3. Reduction in ATP1A1 expression levels is related to major depressive disorder anxiety score.

  4. Our current findings demonstrate that Arctigenin is an antagonist of MR and effectively decreases the Na/K-ATPase 1 gene expression. Our work provides a hint for the drug discovery against cardiovascular disease

  5. Data suggest that targeting Na(+)/K(+) ATPase alpha-1 subunit (ATP1A1) is a approach to the treatment of hepatocellular carcinoma (HCC (show FAM126A Proteins)).

  6. Mutations in ATP1A1 gene is associated with aldosterone-producing adenomas.

  7. Gal-3 (show LGALS3 Proteins) interacts with ATP1A1 and induces the phosphorylation of MDR1, mediating multidrug resistance.

  8. protein kinase A and C activation can increase Na,K-ATPase activity in human muscle but not via P2Y (show P2RY1 Proteins) receptor stimulation.

  9. Mutations of the ATP1A1 depolarize adrenocortical cells, disturb the K+ sensitivity, and lower intracellular pH but do not induce an overt increase of intracellular Ca2 (show CA2 Proteins)+.

  10. Different mutations (KCNJ5 (show KCNJ5 Proteins), ATP1A1, ATP2B3 (show ATP2B3 Proteins), and CACNA1D (show CACNA1D Proteins)) are found in different aldosterone-producing nodules from the same adrenal, suggesting that somatic mutations are independent events triggered by mechanisms that remain to be identified.

Pig (Porcine) ATPase, Na+/K+ Transporting, alpha 1 Polypeptide (ATP1A1) interaction partners

  1. The findings are consistent with previous studies that indicate a link between Na,K-ATPase activity and SFK signaling.

  2. Uroguanylin (show GUCA2B Proteins) modulates (Na++K+)ATPase in a proximal tubule cells via cGMP/protein kinase (show CDK7 Proteins) G, cAMP/protein kinase A, and mTOR (show FRAP1 Proteins) pathways.

  3. Data indicate that magnesium fluoride, magnesium fluoride and Na,K-ATPase form a very stable complex in the E2 conformation.

  4. Data indicate that Rb(+) can be occluded through Na(+)/K(+)-ATPase cycling mode that takes place in the absence of Na(+) ions.

  5. Expression of mutant alpha1 Na/K-ATPase defective in conformational transition attenuates Src (show SRC Proteins)-mediated signal transduction

  6. re-arrangements of the Na+,K+-ATPase stabilized by cardiotonic steroids may affect protein-protein interactions within the intracellular signal transduction networks

  7. Data indicate that the transmembrane domain of the Na+/K+ -ATPase in the E1 state is less exposed to the lipids than in E2.

  8. The plasma membrane Na/K-ATPase-caveolin-1 (show CAV1 Proteins) interaction may represent an important sensing mechanism by which the cells regulate the sterol regulatory element-binding protein (show CNBP Proteins) pathway.

  9. Investigations of K(+)-occlusion by the phosphoenzyme of Na(+),K(+)-ATPase from shark rectal gland and pig kidney by stopped-flow fluorimetry reveal major differences in the kinetics of the two enzymes.

  10. The results indicate that PKC (show FYN Proteins) could be the final target and an integrator molecule of different signaling pathways triggered by angiotensin II (Ang II), which could explain the sustained activation of Na(+)-ATPase by Ang II (show AGT Proteins).

Cow (Bovine) ATPase, Na+/K+ Transporting, alpha 1 Polypeptide (ATP1A1) interaction partners

  1. Suggest ATP1A1 has a central role in the osmoregulatory response of nucleus pulposus cells.

  2. The ATP1A1 gene polymorphism has potential as a marker for mastitis resistance in dairy cattle.

  3. The polymorphisms within the coding region of bovine ATP1A1 gene, were analyzed.

  4. ATP1A1 gene polymorphism has a role in heat tolerance traits in dairy cattle

Xenopus laevis ATPase, Na+/K+ Transporting, alpha 1 Polypeptide (ATP1A1) interaction partners

  1. The C-terminal contacts of Xenopus Na,K-ATPase alpha-1 provide important stabilization of the occluded E1P(Na3) pump conformation, regardless of the route of Na ion entry into the binding pocket.

Rabbit ATPase, Na+/K+ Transporting, alpha 1 Polypeptide (ATP1A1) interaction partners

  1. Na,K-ATPase interaction with magnesium ions

  2. Altered localization of Na-K-ATPase as a result of transcriptional down-regulation of ankyrin-G mediates the down-regulation of Na-K-ATPase activity during chronic intestinal inflammation.

  3. Pb(2+) ions are able to confine the Na(+),K(+)-ATPase into a phosphorylated E(2) state.

Mouse (Murine) ATPase, Na+/K+ Transporting, alpha 1 Polypeptide (ATP1A1) interaction partners

  1. Study identified the Na+/K+-ATPase alpha 1 and 3 subunits as receptors for the extracellular fragment of GPNMB that mediates activation of cellular signaling pathways and subsequent neuroprotective effects.

  2. effects of endogenous acetylcholine on alveolar fluid clearance are likely mediated by Na,K-ATPase function through activation of muscarinic acetylcholine receptors on alveolar epithelia

  3. Oxidized LDL-bound CD36 (show CD36 Proteins) recruits an Na/K-ATPase-Lyn (show LYN Proteins) complex in macrophages that promotes atherosclerosis.

  4. TGFbeta1 (show TGFB1 Proteins) is a powerful regulator of megakaryocytic Na+/K+ ATPase activity.

  5. Inhibition of the Na+/K+-ATPase pathway in astrocytes leads to rearrangement of cytoskeleton.

  6. Reduction of Na/K-ATPase affects cardiac remodeling and increases c-kit cell abundance in partial nephrectomized mice.

  7. Enhanced Na+ entry did not alter Na,K-ATPase a1 mRNA level in tranfected mCDD cells. Post-transcriptional control of Na,K-ATPase abundance is effected by lysosomal degradation.

  8. This coupling of astrocytic A2ARs to the regulation of glutamate (show GRIN1 Proteins) transport through modulation of NKA (show TAC1 Proteins)-alpha2 activity provides a novel mechanism linking neuronal activity to ion homeostasis controlling glutamatergic activity.

  9. Concurrent impairment of Na(+)+K(+)-ATPase function in multi-organ may serve as one of the molecular pathways participating in and contributing to the mechanism of type-1 diabetes-induced complications in NOD mice.

  10. Activation of Na,K-ATPase protects against oxidative damage in an animal model of pentylenetetrazol-induced seizures.

Guinea Pig ATPase, Na+/K+ Transporting, alpha 1 Polypeptide (ATP1A1) interaction partners

  1. Data identify the K+-independent, ouabain-insensitive Na+-ATPase as a unique P-type ATPase (show ATP7A Proteins).

ATP1A1 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with ATP1A1

  • ATPase, Na+/K+ transporting, alpha 1 polypeptide (ATP1A1)
  • ATPase, Na+/K+ transporting, alpha 1 polypeptide (Atp1a1)
  • ATPase, Na+/K+ transporting, alpha 1 polypeptide (atp1a1-a)
  • atp1a1 protein
  • atp1a1a.1 protein
  • Atpa-1 protein
  • BC010319 protein
  • K-ATPase protein
  • Na+K+ATPase protein
  • Nkaa1b protein

Protein level used designations for ATP1A1

Na/K ATPase , (Na+ + K+)-ATPase , Na(+)/K(+) ATPase alpha-1 subunit , sodium pump subunit alpha-1 , sodium/potassium-transporting ATPase subunit alpha-1 , Na+, K+ ATPase alpha subunit , Na+/K+ ATPase 1 , Na, K-ATPase, alpha-A catalytic polypeptide , Na,K-ATPase alpha-1 subunit , Na,K-ATPase catalytic subunit alpha-A protein , sodium pump 1 , sodium-potassium ATPase catalytic subunit alpha-1 , sodium-potassium-ATPase, alpha 1 polypeptide , ATPase, Na+K+ transporting, alpha 1 , (Na+, K+)-ATPase alpha-subunit , Na+/K+ transporting alpha 1 polypeptide , sodium/potassium-transporting ATPase alpha-1 chain , Na+-K+-ATPase alpha 1 subunit , Na+/K+ ATPase , Na+K+ ATPase , Na+/K+ -ATPase alpha 1 subunit , Na/K ATPase alpha 1 subunit , sodium/potassium-ATPase alpha-subunit 1 , alpha1 subunit of equine Na/K ATPase , horse alpha-1 subunit of Na,K-ATPase

100303690 Meleagris gallopavo
396530 Gallus gallus
476 Homo sapiens
403992 Canis lupus familiaris
24211 Rattus norvegicus
397481 Sus scrofa
282144 Bos taurus
443381 Ovis aries
399285 Xenopus laevis
100302415 Oryctolagus cuniculus
11928 Mus musculus
100192382 Cavia porcellus
100034139 Equus caballus
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