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The Na(+)/K(+)-ATPase (show ATP1A1 Proteins) pump (NKA (show TAC1 Proteins)) was less abundant in the basolateral membrane and was mislocalized to apical bundles in ap1b1 (show AP1B1 Proteins) mutant hair cells.
Data indicate that Atp1a1 and Fxyd1 (show FXYD1 Proteins) co-regulate brain ventricle development.
Atp1a1 activity in the yolk syncytial layer regulates zebrafish heart tube morphogenesis.
identification of a mutant, heart and mind, (had) which exhibits multiple cardiac defects; molecular cloning reveals that the lesion resides in the alpha1B1 isoform of Na,K-ATPase (show ATP1A1 Proteins).
the Na,K-ATPase (show ATP1A1 Proteins) is (show ATP11A Proteins) required downstream or in parallel to monocilia function during initiation of left-right asymmetry in zebrafish
Na(+),K(+) ATPase (show ATP1A1 Proteins) activity is positively regulated via an N-terminal phosphorylation site that is necessary for correct heart morphogenesis to occur.
Human ATP1A4 enhances mouse sperm motility and hyperactivity during capacitation.
Human Na,K-ATPase alpha 4 isoform is a sperm-specific protein localized to the flagellum, suggesting a role for human Na,K-ATPase alpha 4 isoform in human sperm physiology.
These results constitute the first demonstration of the transcriptional control of ATP1A4 gene expression by cAMP and by CREMtau, a transcription factor essential for male germ cell gene expression.
data suggests that both the promoter and the intragenic CGI could combine to provide multiple modes of regulation for optimizing the Atp1a4 expression level in a cell type-specific manner.
These findings highlight the exquisite spatial and temporal control of expression exerted by the Atp1a4 promoter on Na,K-ATPase (show ATP1A1 Proteins) alpha4, which is particularly well suited to fulfill the special functions of spermatozoa.
Na,K-ATPase (show ATP1A1 Proteins) alpha4 isoform is essential for sperm fertility
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.
ATPase, Na+/K+ transporting, alpha 1 polypeptide like 1
, ATPase, Na+/K+ transporting, alpha 1a.1 polypeptide
, Na+/K+ -ATPase alpha 1 subunit
, heart and mind
, ATPase, Na+/K+ transporting, alpha polypeptide-like 2
, Na(+)/K(+) ATPase alpha-4 subunit
, Na+/K+ ATPase 4
, Na+/K+ ATPase, alpha-D polypeptide
, Na,K-ATPase subunit alpha-C
, sodium pump 4
, sodium pump subunit alpha-4
, sodium-potassium ATPase catalytic subunit alpha-4
, sodium/potassium-transporting ATPase alpha-4 chain
, sodium/potassium-transporting ATPase subunit alpha-4
, Na+/K+ ATPase alpha 4 subunit