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Recurrent FXYD2 p.Gly41Arg mutation is associated with isolated dominant hypomagnesaemia.
FXYD2b could regulate the Na,K-ATPase (show ATP1A1 ELISA Kits) by modulating the effective membrane surface electrostatics near the ion binding sites of the pump.
our findings suggested that FXYD2c played a role in regulation of NKA (show TAC1 ELISA Kits) activity by enhancing the expression of NKA (show TAC1 ELISA Kits) in HK-2 (show HK2 ELISA Kits) cells upon hypertonic challenge.
PCBD1 (show PCBD1 ELISA Kits) (dimerization cofactor of HNF-1alpha (show HNF1A ELISA Kits)) is coactivator of the HNF1B (show HNF1B ELISA Kits)-mediated transcription necessary for fine tuning ATPase Na+/K+ transporting gamma 1 polypeptide (FXYD2) transcription in the distal convoluted tubule.
This is the first report demonstrating the potential utility of FXYD2 immunohistochemistry in the diagnosis of chromophobe renal cell carcinoma
findings confirm the presence of an FXYD2 peptide in the crab gill Na,K-ATPase (show ATP1A1 ELISA Kits) and demonstrate that this peptide plays an important role in regulating enzyme activity
wild type HNF1B specifically induces FXYD2A transcription whereas all HNF1B mutants partially prevented it.
Study reveals, in various human tissues, the specific expression of FXYD2, which may associate with Na, K-ATPase (show ATP1A1 ELISA Kits) in selected cell types and modulate its catalytic properties.
Data conclude that human proximal tubular cells respond to a hyperosmotic challenge with an increase in FXYD2 and Na,K-ATPase (show ATP1A1 ELISA Kits) protein expression, though to a smaller absolute extent in patient cells.
Activity of GLAST (show SLC1A3 ELISA Kits) directs FXYD2 protein/gamma subunit to the cell surface, that leads to the activation of the astroglial sodium pump.
FXYD2 activity may be a fundamental mechanism underlying the persistent hypersensitivity to pain induced by inflammation.
Data suggest that in pancreatic beta cells regulatory subunit of Na,K-ATPase (show ATP1A1 ELISA Kits) FXYD2 plays a role in Akt (show AKT1 ELISA Kits) signaling pathways associated with cell growth and proliferation.
The transcription factor Runx1 (show RUNX1 ELISA Kits) controls FXYD2 expression during the maturation of the somato (show SSTR5 ELISA Kits)-sensory system, partly through regulation of the tyrosine kinase receptor (show KDR ELISA Kits) Ret (show RET ELISA Kits).
Fxyd2 encodes three mRNAs that have tissue-specific expression patterns.
the gamma-subunit has an important role in the function of Na-K-ATPase (show ATP1A1 ELISA Kits) to sustain the cellular cation balance over the plasma membrane in a hypertonic environment.
FXYD2 has a role in Na+ affinity and regulating thermal stability in mice
This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes the sodium/potassium-transporting ATPase subunit gamma. Mutations in this gene have been associated with Renal Hypomagnesemia-2. Alternatively spliced transcript variants have been described. Read-through transcripts have been observed between this locus and the upstream FXYD domain-containing ion transport regulator 6 (FXYD6, GeneID 53826) locus.
ATPase, Na+/K+ transporting, gamma 1 polypeptide
, Na(+)/K(+) ATPase subunit gamma
, sodium pump gamma chain
, sodium/potassium-transporting ATPase subunit gamma
, FXYD domain-containing ion transport regulator 2
, sodium/potassium-transporting ATPase gamma chain
, Na,K-ATPase gamma
, gamma subunit of Na,K-ATPase
, FXTD domain-containing ion transport regulator 2
, gamma subunit of sodium potassium ATPase
, Sodium/potassium-transporting ATPase gamma chain