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GPx-1 expression deters the unfolded protein response following exposure to cigarette smoke
Knockdown of GPX1 in hucMSCs abrogated antioxidant and anti-apoptotic abilities of hucMSC-Ex and diminished the hepatoprotective effects of hucMSC-Ex in vitro and in vivo. Thus, hucMSC-Ex promote the recovery of hepatic oxidant injury through the delivery of GPX1.
The potential protective effect without statistical relationships were also observed for other genotypes and alleles studied polymorphic variants of antioxidant enzymes in CD and CAT- 262C / T and + 35 A / C SOD1 (show SOD1 Proteins) in UC. Conducted our audit should be extended to more group of patients in order to assess whether or not to confirm the observed during analysis, the protective effect of CAT-262 C / T in ulcerative colitis and
No significant differences in SOD (show SOD1 Proteins) and GPx activity both in plasma and saliva (show RAG1AP1 Proteins) were found between Crohn's Disease remission group and the control group.
GPX1 and SEPP1 (show SEPP1 Proteins) Single Nucleotide Polymorphism were not associated with any changes in the expression of related genes. GPX1 was shown to modulate the expression of unrelated target, SEP15 (show SEP15 Proteins), upon Se supplementation, both alone and in combination with SEPP1 (show SEPP1 Proteins).
Study demonstrates that SOD2 (show SOD2 Proteins) rs4880, GPX1 rs1050450 and CAT rs1001179 are not associated with an increased susceptibility to epilepsy after neonatal hypoxic-ischemic encephalopathyor its drug resistance
Data show that antioxidant enzymes SOD2 (show SOD2 Proteins) and GPX1 expression and GPX1 and SOD1 (show SOD1 Proteins) activity were significantly higher in patients at diagnosis of bladder cancer (BC) in comparison to controls.
Data show that the placement of rectus sheath block (RSB) analgesia did not significantly affect the level of oxidative stress biomarker plasma glutathione peroxidase (show GPX3 Proteins) (GPX1) level in patients with benign disease or cancer.
Adiponectin gene promoter -11377C/G (CG), -11377C/G (GG), GPx-1 gene C594T (CT), C594T (TT), and cigarette smoking are risk factors in nonalcoholic fatty liver disease (NAFLD).
Our results suggest that GSTP1 rs1695 and GPX1 rs1050450 single nucleotide polymorphisms have no effect on the risk of preeclampsia in the Chinese Han population.
Glutathione peroxidase 1 (GPx1) knockdown not only induced oxidative stress characterized by the increased production of reactive oxygen species (ROS (show ROS1 Proteins)) but also caused reductive stress indicated by an elevation of glutathione (GSH)/oxidized GSH (GSSG) ratio.
Exposure to far infrared rays significantly protects acute restraint stress oxidative burdens via inhibition of JAK2 (show JAK2 Proteins)/STAT3 (show STAT3 Proteins) signaling by induction of GPx-1.
Genetic inhibition of Gpx1 potentiates cocaine-induced renal damage via activation of AT1R (show AGTRAP Proteins) by inhibition of PI3K-Akt (show AKT1 Proteins) signaling.
Glutathione peroxidase 1 deficiency attenuates concanavalin A-induced liver injury by induction of T-cell hyporesponsiveness through chronic reactive oxygen species exposure.
GPx1 was found to play a critical role in regulating pro-inflammatory pathways in vascular endothelium.
Plasmalogen enrichment via batyl alcohol supplementation attenuated atherosclerosis in ApoE (show APOE Proteins)- and ApoE (show APOE Proteins)/GPx1-deficient mice.
Gpx1 expression in the mouse skeletal muscle can be altered by both exercise and dyslipidemia through changes in DNA methylation (show HELLS Proteins), leading to a fine regulation of free radical metabolism.
our findings unveil a new metabolic role for Reg3beta in protein nitration and a new biosynthesis control of GPX1 by a completely "unrelated" regenerating protein, Reg3beta, via transcriptional activation of Scly (show SCLY Proteins)
Rora (show RORA Proteins) induces the mRNA level of antioxidant enzymes, superoxide dismutase 2 (show SOD2 Proteins) and glutathione peroxidase 1, through the Rora (show RORA Proteins) response elements located in the upstream promoters of Sod2 (show SOD2 Proteins) and Gpx1.
Studied the importance of selenium in bovine female reproductive function. Gene expression analysis revealed selenoprotein gene GPX1 was significantly up-regulated in large healthy follicles.
did not find any significant inhibition of bovine GPx-1 by (S)- or (R)-misonidazole.
Data indicate mRNA level and activity of GPx1 are regulated by level of selenium supplied to hepatocytes.
homocysteine decreases GPx1 activity by altering the translational mechanism
glutathione peroxidase-1 activity is decreased by aminoglycosides through interference with selenocysteine incorporation
GPx1 plays a key role in blocking the promotion of porcine circovirus type 2 replication
The developmental expression of GPX1 and thioredoxin reductase during fetal development and the effect of maternal selenium consumption on the expression of these proteins are reported.
This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. This protein is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by UGA, that normally functions as a translation termination codon. In addition, this protein is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with five, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA repeats is significantly associated with breast cancer risk. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
glutathione peroxidase Gpx1
, glutathione peroxidase
, putative glutathione peroxidase
, glutathione peroxidase 1
, cellular glutathione peroxidase
, selenium-dependent glutathione peroxidase 1
, cytosolic glutathione peroxidase