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The authors cloned cytosolic glutathione peroxidase (GPx1 (show GPX1 Proteins)) and phospholipid hydroperoxide glutathione peroxidase (GPx4) genes in rainbow trout (Oncorhynchus mykiss). Constitutive mRNA expression and responsiveness to Se availability was analysed.
High glutathione peroxidase 2 expression is associated with radiation induced lung disease.
we propose that ileocolitis in the GPx1 (show GPX1 Proteins)/2-double-knockout mice is caused by Nox1 (show NOX1 Proteins), which is induced by TNF (show TNF Proteins)
GPx2 is up-regulated in dysplastic colonic crypts, where it appears to act inhibit apoptosis and, thus, supports tumor development.
Candidate colitis genes in the Gdac1 locus of mice deficient in glutathione peroxidase-1 (show GPX1 Proteins) and -2, were analyzed.
it is concluded that GPx2, although supporting tumor growth, inhibits inflammation-mediated tumorigenesis, but the protective effect of selenium does not strictly depend on GPx2 expression
study indicates GI-GPx is spatiotemporally expressed in embryonic organs during organogenesis and may also perform a mutual compensatory role with cGPx (show GPX1 Proteins) in protecting embryos and extraembryonic tissues against reactive oxygen species
Loss of Gpx2 is associated with diet induced severe colitis.
In GPx2 KO mice, an increase in GPx1 (show GPX1 Proteins) can only partially compensate for GPx2, even under selenium supplementation, indicating that GPx2 is the major antiapoptotic GPx (show PRDX6 Proteins) in the colon.
Genes encoding the antioxidants GPX2 and GSTO 1-1 (show GSTO1 Proteins) are common inflammatory genes expressed upon induction of allergic airway inflammation, and independently of allergic susceptibility.
GPX1 (show GPX1 Proteins)-DKO and GPX2-DKO mice are highly susceptible to bacteria-associated inflammation and cancer.
Cardamonin exposure and selenium availability regulate expression of HO-1 (show HMOX1 Proteins), GPX2 and TrxR1 (show TXNRD1 Proteins) in human intestinal cells.
GPX2 underexpression is associated with advanced tumor status and implicated unfavorable clinical outcome of UCs, suggesting its role in tumor progression and may serve as a theranostic biomarker of UCs.
high GPx2 expression was associated with early tumor recurrence, particularly in the recently identified aggressive subtype of human colon cancer.
Patients with high GPX2 expression in biopsy specimen had significantly lower prostate-specific antigen (show KLK3 Proteins) recurrence-free survival and overall survival than those with no GPX2 expression.
miR (show MLXIP Proteins)-185 plays a role in up-regulation of GPX2 and SEPHS2 (show SEPHS2 Proteins) expression.
A role of GPx2, TrxR2 (show TXNRD2 Proteins) and TrxR3 (show TXNRD3 Proteins) in proliferation, apoptosis and, therefore, also during cancer development.
A GPx2-independent decrease in tumor development by selenium (Se) and detrimental effects of the Nrf2 (show GABPA Proteins)-activator sulforaphane in moderate Se deficiency.
Cellular and subcellular localization of gastrointestinal glutathione peroxidase in normal and malignant human intestinal tissue
Data suggest that some antioxidants may exert their anti-inflammatory and anticarcinogenic effects not only by induction of phase 2 enzymes but also by the up-regulation of the selenoprotein GI-GPx by Nrf2 (show GABPA Proteins) binding.
some isoforms of p63 (show RPE65 Proteins) serve as a pro-survival factor by up-regulating GPX2 to reduce the p53 (show TP53 Proteins)-dependent oxidative stress-induced (show SQSTM1 Proteins) apoptotic response
This gene is a member of the glutathione peroxidase family and encodes a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract. The protein encoded by this locus contains a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. Alternatively spliced transcript variants have been described.
glutathione peroxidase type 2
, glutathione peroxidase 2
, glutathione peroxidase-gastrointestinal
, intestinal GPx
, gastrointestinal glutathione peroxidase
, glutathione peroxidase-related protein 2