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enzymatic epididymal salvage response is sufficient to maintain full fertility of double GPx4 and GPx5 KO males whatever their age, crossed with young WT female mice
GPX5 is found in the caput & cauda epididymis lumen in 3 locations: as a soluble protein in the caput epididymal fluid, weakly bound to caput sperm membranes, or associated to lipid-containing structures causing a protective effect against proteolysis.
GPX5 gene is expressed in a temporally regulated manner during mouse embryonic development.
results reveal that expression of Nm23-M5 plays a critical role in spermiogenesis by increasing the cellular levels of GPX-5 to eliminate reactive oxygen species
GPX5 is a potent antioxidant scavenger in the luminal compartment of the mouse cauda epididymidis that protects spermatozoa from oxidative injuries.
Sperm TPI content and amounts of GPX5 in seminal plasma may be used as quality markers of boar sperm.
This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike mRNAs for other characterized glutathione peroxidases, this mRNA does not contain a selenocysteine (UGA) codon. Thus, the encoded protein is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
, epididymal secretory glutathione peroxidase
, epididymis-specific glutathione peroxidase-like protein
, lysosomal trafficking regulator, long splice form
, major androgen-regulated protein
, glutathione peroxidase 5
, epididymal androgen-related protein
, epididymis-specific secretory glutathione peroxidase-like protein GPX5
, epididymis-specific glutathione peroxidase 23kDa subunit