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Human Thyroglobulin Protein expressed in Human - ABIN934700
Brorson, Reinholt: The intensity of immunogold labeling of deplasticized acrylic sections compared to deplasticized epoxy sections-Theoretical deductions and experimental data. in Micron (Oxford, England : 1993) 2008
Mutations in Thyroglobulin gene is associated with metastasis in Thyroid Cancer.
Mutations in the genes for thyroglobulin and thyroid peroxidase (show TPO Proteins) cause thyroid dyshormonogenesis and autosomal-recessive intellectual disability
Patients with low-and intermediate-risk differentiated thyroid carcinoma could be considered cured when their serum thyroglobulin levels were changed 6-12 months after thyroid ablation.
The system is characterized by a very high sensitivity and specificity allowing the ex-vivo detection of sub ng/ml concentrations of human Thyroglobulin from needle washouts of fine-needle aspiration biopsies of thyroid nodule from different patients.
High Thyroglobulin Levels are associated with recurrence in Thyroid Carcinoma.
+49A/G and CT60 polymorphism of CTLA4 (show CTLA4 Proteins) and E33 (show NDUFAF3 Proteins) polymorphism of TG may be genetic risk factors for autoimmune hypothyroidism susceptibility.
A prominent transient early increase in thyroglobulin levels was found in thyroid cancer patients post-radioiodine ablation.
The mean and median of thyroglobulin were calculated in these subgroups. Tg concentrations were dependent on gender/
Results from a Vietnamese family with goiter and hypothyroidism identified 2 novel mutations in thyroglobulin gene resulting in the abolition of the authentic splice donor sites.
Data suggest serum TG level (low but measurable following stimulation with recombinant thyroid stimulating hormone or withdrawal of thyroid hormone (show PTH Proteins)) is predictive of incomplete response to surgery/radioiodine therapy in differentiated thyroid cancer.
Final acquisition of secretory competence includes conformational maturation in the interval between linker and hinge segments of region I of thyroglobulin.
The results showed that thyroglobulin message or protein is not expressed in placenta, decidua, or ovary in any stages of pregnancy.
Findings demonstrate a novel aspect of murine and human thyroid autoimmunity, namely breaking B cell self-tolerance occurs first for Tg and subsequently for TPO (show THPO Proteins).
These results indicate that Runx2 (show RUNX2 Proteins) deficiency in mice causes decreased Tg expression and a novel type of hypothyroidism.
Five novel autoimmune thyroiditis-causing T cell epitopes of thyroglobulin (Tgn) have been delineated and mapped with an algorithm that predicts Tgn immunopathogenic peptides containing I-A(k)-binding motifs.
iodotyrosyl formation in normal thyroglobulin confers pathogenic potential to certain peptides that may otherwise remain innocuous and undetectable by conventional mapping methods
Tg could initiate glomerular injury by reproducing the actions of TGF-beta1 (show TGFB1 Proteins) in the mesangial cell.
Solution studies, size exclusion chromatography, dynamic light scattering and analytical ultracentrifugation, demonstrated the size changes of thyroglobulin oligomers after nitric oxide treatment.
The genetic effects of thyroglobulin and casein alpha s1 (show CSN1S1 Proteins) alpha in the body fat distribution of cattle are reported.
Localization of thyrotropin receptor (show TSHR Proteins) and thyroglobulin in the bovine corpus luteum.
Atrial natriuretic peptide (show NPPA Proteins) inhibits iodide uptake and thyroglobulin messenger ribonucleic acid expression in cultured bovine thyroid follicles.
Markers at the thyroglobulin gene may be a useful predictor of marbling performance for producers raising Wagyu-based cattle; the SNP reported in the thyroglobulin gene was associated with marbling score in cattle with Wagyu inheritance
Single nucleotide polymorphism of thyroglobulin gene is associated with fat deposition.
we have demonstrated for the first time that thyroglobulin possesses proliferative effect on thyroid epithelial cells in addition to being the precursor of the thyroid hormones.
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.
, congenital goiter
, hereditary goitre