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In conclusion, we demonstrated in this study for the first time that periodontal CD36 expression was associated with MetS (show MARS ELISA Kits)-exacerbated periodontitis. We also demonstrated that CD36 is involved in the enhancement by palmitate of LPS (show TLR4 ELISA Kits)-induced inflammatory molecule expression in macrophages.
Results show that CD36 and Platelet-Activating Factor Receptor (show PTAFR ELISA Kits) are important mediators of house dust mites (HDM (show HDAC3 ELISA Kits)) allergy development and that inhibiting HDM (show HDAC3 ELISA Kits) engagement with phosphorylcholine receptors in the lung protects against allergic airway disease.
Our results suggest that LPA-enhanced foam cell formation is mediated by LPA1 (show LPAR1 ELISA Kits)/3 -AKT (show AKT1 ELISA Kits) activation and subsequent SRBI (show SCARB1 ELISA Kits) expression.
These findings suggest that atherogenic conditions critically regulate platelet CD36 signaling by increasing superoxide radical anion and hydrogen peroxide through a mechanism that promotes activation of MAPK (show MAPK1 ELISA Kits) ERK5 (show MAPK7 ELISA Kits).
the results obtained from Ccr2 (show CCR2 ELISA Kits)(-/-), Cd36(-/-), and CD36 bone marrow chimeric mice showed that sequestration in the absence of CD36-mediated phagocytic clearance by monocytes leads to exaggerated lung pathologic features.
In addition, purinergic receptor P2X, ligand-gated ion channel (show ZACN ELISA Kits) 7 (P2X7 (show P2RX7 ELISA Kits)) was downregulated in CD36-knockdown 3T3-L1 cells, suggesting that the suppression of CD36 attenuates adipogenesis via the P2X7 (show P2RX7 ELISA Kits) pathway in 3T3-L1 cells.
Data suggest that the transmembrane domains of Tlr4 (show TLR4 ELISA Kits) and Tlr6 (show TLR6 ELISA Kits) have essential roles in Tlr4 (show TLR4 ELISA Kits)/Tlr6 (show TLR6 ELISA Kits)/Cd36 receptor multimerization and activation; disruption of receptor multimerization (here, using a recombinant peptide fragment from Tlr4 (show TLR4 ELISA Kits) transmembrane domain) reduces secretion of proinflammatory mediators from microglia and ultimately rescues neurons from death.
Results show the first high-resolution structure of the C-terminal transmembrane domain of SR-BI (show SCARB1 ELISA Kits). This region of SR-BI (show SCARB1 ELISA Kits) harbors a leucine zipper dimerization motif, which when mutated impairs the ability of the receptor to bind HDL (show HSD11B1 ELISA Kits) and mediate cholesterol delivery.
Cardiotonic steroids activate NF-kappaB (show NFKB1 ELISA Kits) leading to proinflammatory cytokine production in primary macrophages through a signaling complex, including CD36, TLR4 (show TLR4 ELISA Kits), and Na/K-ATPase (show ATP1A1 ELISA Kits).
Data show that all the six inflammation-related CpG-SNPs genotypes including IL1B (show IL1B ELISA Kits) rs16944, IL1R2 (show IL1R2 ELISA Kits) rs2071008, PLA2G7 (show Lp-PLA2 ELISA Kits) rs9395208, FAM5C rs12732361, CD40 (show CD40 ELISA Kits) rs1800686, and CD36 rs2065666 were associated with coronary heart disease (CHD (show CHDH ELISA Kits)), suggesting an important role of inflammation in the risk of CHD (show CHDH ELISA Kits).
CD36 single nucleotide polymorphisms rs1194182 and rs10499859 reduce risk to pulmonary tuberculosis in a Chinese Han population.
CD36 and MARCO are associated with the susceptibility of Chinese Han females to carotid atherosclerosis. Menopausal status may affect the association between gene polymorphisms and carotid atherosclerosis in the female Chinese Han population.
this study shows that diet-induced obesity links to estrogen receptor (show ESR1 ELISA Kits)-positive breast cancer progression via LPA (show APOA ELISA Kits)/PKD-1 (show PKD1 ELISA Kits)-CD36 signaling-mediated microvascular remodeling
High CD36 expression is associated with Acute Monocytic Leukemia (show KAT6B ELISA Kits).
Common CD36 SNPs reduce adipose and heart CD36 levels to higher chylomicron remnants and LDL in humans.
this studies provide evidence that CD36 mediates surfactant lipid uptake by human macrophages and that Mycobacterium tuberculosis exploits this function for growth
a substantial fraction of unligated CD36 exists in nanoclusters, which not only promote TSP-1 (show THBS1 ELISA Kits) binding but are also enriched with the downstream effector Fyn (show FYN ELISA Kits).
These results suggest that increased expression of hepatic CD36 and SREBP-1 (show SREBF1 ELISA Kits) is relevant in the obesity-driven lipid accumulation in the liver of dairy cows during late gestation.
Gammadelta T cells express CD36 and it contributes to responses by these cells to microbial lipoteichoic acid.
Niacin Reduces serum level and adipose mRNA expression of leptin (show LEP ELISA Kits) and up-regulates PPARgamma (show PPARG ELISA Kits) and CD36 mRNA expression in hypercholesterolemic rabbits.
Amyloid-beta inhibits No-cGMP signaling in a CD36- and CD47 (show CD47 ELISA Kits)-dependent manner
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
, enkephalin convertase
, prohormone-processing carboxypeptidase
, PAS IV
, fatty acid translocase
, glycoprotein IIIb
, platelet glycoprotein 4
, platelet glycoprotein IV
, CD36 antigen (collagen type I receptor, thrombospondin receptor)
, PAS-4 protein
, cluster determinant 36
, leukocyte differentiation antigen CD36
, scavenger receptor class B, member 3
, CD36 antigen like
, CD36 antigen
, adipocyte membrane protein
, collagen type I receptor thrombospondin receptor
, fatty acid transport protein
, fatty acid translocase/CD36
, collagen type I receptor, thrombospondin receptor
, FAT tumor suppressor homolog 1
, cadherin FAT1 isoform +12
, protocadherin Fat 1
, FAT tumor suppressor homolog 1 (Drosophila)
, HDL QTL 1
, scavenger receptor class B member 1
, scavenger receptor class B type I
, scavenger receptor class B1