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Human CD36 Protein expressed in Human Cells - ABIN2003345
Xu, Efremov, Li, Lai, Dao, Lim, Cao: Probing the cytoadherence of malaria infected red blood cells under flow. in PLoS ONE 2013
In conclusion, we demonstrated in this study for the first time that periodontal CD36 expression was associated with MetS-exacerbated periodontitis. We also demonstrated that CD36 is involved in the enhancement by palmitate of LPS (show TLR4 Proteins)-induced inflammatory molecule expression in macrophages.
Results show that CD36 and Platelet-Activating Factor Receptor (show PTAFR Proteins) are important mediators of house dust mites (HDM (show HDAC3 Proteins)) allergy development and that inhibiting HDM (show HDAC3 Proteins) engagement with phosphorylcholine receptors in the lung protects against allergic airway disease.
Our results suggest that LPA-enhanced foam cell formation is mediated by LPA1 (show LPAR1 Proteins)/3 -AKT (show AKT1 Proteins) activation and subsequent SRBI (show SCARB1 Proteins) expression.
These findings suggest that atherogenic conditions critically regulate platelet CD36 signaling by increasing superoxide radical anion and hydrogen peroxide through a mechanism that promotes activation of MAPK (show MAPK1 Proteins) ERK5 (show MAPK7 Proteins).
the results obtained from Ccr2 (show CCR2 Proteins)(-/-), Cd36(-/-), and CD36 bone marrow chimeric mice showed that sequestration in the absence of CD36-mediated phagocytic clearance by monocytes leads to exaggerated lung pathologic features.
In addition, purinergic receptor P2X, ligand-gated ion channel 7 (P2X7 (show P2RX7 Proteins)) was downregulated in CD36-knockdown 3T3-L1 cells, suggesting that the suppression of CD36 attenuates adipogenesis via the P2X7 (show P2RX7 Proteins) pathway in 3T3-L1 cells.
Data suggest that the transmembrane domains of Tlr4 (show TLR4 Proteins) and Tlr6 (show TLR6 Proteins) have essential roles in Tlr4 (show TLR4 Proteins)/Tlr6 (show TLR6 Proteins)/Cd36 receptor multimerization and activation; disruption of receptor multimerization (here, using a recombinant peptide fragment from Tlr4 (show TLR4 Proteins) transmembrane domain) reduces secretion of proinflammatory mediators from microglia and ultimately rescues neurons from death.
Results show the first high-resolution structure of the C-terminal transmembrane domain of SR-BI (show SCARB1 Proteins). This region of SR-BI (show SCARB1 Proteins) harbors a leucine zipper dimerization motif, which when mutated impairs the ability of the receptor to bind HDL (show HSD11B1 Proteins) and mediate cholesterol delivery.
Cardiotonic steroids activate NF-kappaB (show NFKB1 Proteins) leading to proinflammatory cytokine production in primary macrophages through a signaling complex, including CD36, TLR4 (show TLR4 Proteins), and Na/K-ATPase (show ATP1A1 Proteins).
CD36 single nucleotide polymorphisms rs1194182 and rs10499859 reduce risk to pulmonary tuberculosis in a Chinese Han population.
CD36 and MARCO are associated with the susceptibility of Chinese Han females to carotid atherosclerosis. Menopausal status may affect the association between gene polymorphisms and carotid atherosclerosis in the female Chinese Han population.
this study shows that diet-induced obesity links to estrogen receptor (show ESR1 Proteins)-positive breast cancer progression via LPA (show APOA Proteins)/PKD-1 (show PKD1 Proteins)-CD36 signaling-mediated microvascular remodeling
High CD36 expression is associated with Acute Monocytic Leukemia (show KAT6B Proteins).
Common CD36 SNPs reduce adipose and heart CD36 levels to higher chylomicron remnants and LDL in humans.
this studies provide evidence that CD36 mediates surfactant lipid uptake by human macrophages and that Mycobacterium tuberculosis exploits this function for growth
a substantial fraction of unligated CD36 exists in nanoclusters, which not only promote TSP-1 (show THBS1 Proteins) binding but are also enriched with the downstream effector Fyn (show FYN Proteins).
Influence of a common genetic variant in CD36 on susceptibility to endothelial dysfunction and its response to sildenafil treatment.
These results suggest that increased expression of hepatic CD36 and SREBP-1 (show SREBF1 Proteins) is relevant in the obesity-driven lipid accumulation in the liver of dairy cows during late gestation.
Gammadelta T cells express CD36 and it contributes to responses by these cells to microbial lipoteichoic acid.
Niacin Reduces serum level and adipose mRNA expression of leptin (show LEP Proteins) and up-regulates PPARgamma (show PPARG Proteins) and CD36 mRNA expression in hypercholesterolemic rabbits.
Amyloid-beta inhibits No-cGMP signaling in a CD36- and CD47 (show CD47 Proteins)-dependent manner
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
, enkephalin convertase
, prohormone-processing carboxypeptidase
, PAS IV
, fatty acid translocase
, glycoprotein IIIb
, platelet glycoprotein 4
, platelet glycoprotein IV
, CD36 antigen (collagen type I receptor, thrombospondin receptor)
, PAS-4 protein
, cluster determinant 36
, leukocyte differentiation antigen CD36
, scavenger receptor class B, member 3
, CD36 antigen like
, CD36 antigen
, adipocyte membrane protein
, collagen type I receptor thrombospondin receptor
, fatty acid transport protein
, fatty acid translocase/CD36
, collagen type I receptor, thrombospondin receptor
, FAT tumor suppressor homolog 1
, cadherin FAT1 isoform +12
, protocadherin Fat 1
, FAT tumor suppressor homolog 1 (Drosophila)
, HDL QTL 1
, scavenger receptor class B member 1
, scavenger receptor class B type I
, scavenger receptor class B1