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Browse our anti-PTPN1 (PTPN1) Antibodies

Full name:
anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 Antibodies (PTPN1)
On www.antibodies-online.com are 235 Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) Antibodies from 28 different suppliers available. Additionally we are shipping PTPN1 Kits (36) and PTPN1 Proteins (21) and many more products for this protein. A total of 305 PTPN1 products are currently listed.
Synonyms:
CPTP1, Ptp, PTP-1B, PTP-HA2, ptp1b, PTPN1, wu:fk54h03
list all antibodies Gene Name GeneID UniProt
PTPN1 5770 P18031
PTPN1 19246 P35821
PTPN1 24697 P20417

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Most Popular Reactivities for anti-PTPN1 (PTPN1) Antibodies

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anti-Human PTPN1 Antibodies:

anti-Mouse (Murine) PTPN1 Antibodies:

anti-Rat (Rattus) PTPN1 Antibodies:

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Top referenced anti-PTPN1 Antibodies

  1. Human Polyclonal PTPN1 Primary Antibody for WB - ABIN1882122 : Blincoe, Chidambaram, Salari, Bond, Evans, Gray-Kaufman, Griffey, Tranby, Garner-Johnson, Lee, Sorenson: Pharmacokinetic distribution of 67Cu(II)2[3,5-diisopropyl(carboxy-14C)salicylate]4 among murine tissues. in Current medicinal chemistry 2004 (PubMed)
    Show all 6 references for ABIN1882122

  2. Human Polyclonal PTPN1 Primary Antibody for EIA, WB - ABIN360735 : Ragab, Bodin, Viala, Chap, Payrastre, Ragab-Thomas: The tyrosine phosphatase 1B regulates linker for activation of T-cell phosphorylation and platelet aggregation upon FcgammaRIIa cross-linking. in The Journal of biological chemistry 2003 (PubMed)
    Show all 5 references for ABIN360735

  3. Chicken Monoclonal PTPN1 Primary Antibody for IF, IP - ABIN967772 : Bharadwaj, Ali, Ovsenek: Multiple components of the HSP90 chaperone complex function in regulation of heat shock factor 1 In vivo. in Molecular and cellular biology 2000 (PubMed)
    Show all 5 references for ABIN967772

  4. Mouse (Murine) Polyclonal PTPN1 Primary Antibody for WB - ABIN1881705 : Stuible, Tremblay: In control at the ER: PTP1B and the down-regulation of RTKs by dephosphorylation and endocytosis. in Trends in cell biology 2010 (PubMed)
    Show all 4 references for ABIN1881705

  5. Human Polyclonal PTPN1 Primary Antibody for IP - ABIN440507 : Tsou, Talia, Pinney, Kendzicky, Piera-Velazquez, Jimenez, Seibold, Phillips, Koch: Effect of oxidative stress on protein tyrosine phosphatase 1B in scleroderma dermal fibroblasts. in Arthritis and rheumatism 2012 (PubMed)

  6. Cow (Bovine) Polyclonal PTPN1 Primary Antibody for WB - ABIN2782192 : Malecki, Cyganek, Mirkiewicz-Sieradzka, Wolkow, Wanic, Skupien, Solnica, Sieradzki: Alanine variant of the Pro12Ala polymorphism of the PPARgamma gene might be associated with decreased risk of diabetic retinopathy in type 2 diabetes. in Diabetes research and clinical practice 2008 (PubMed)

  7. Human Monoclonal PTPN1 Primary Antibody for ELISA, WB - ABIN411571 : Gan, Zhang, Buckels, Paterson, Jiang, Clemens, Zhang, Du, Chang, Frank: IGF-1R modulation of acute GH-induced STAT5 signaling: role of protein tyrosine phosphatase activity. in Molecular endocrinology (Baltimore, Md.) 2013 (PubMed)

More Antibodies against PTPN1 Interaction Partners

Human Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) interaction partners

  1. PTP1B/RNF213 (show RNF213 Antibodies)/alpha-KGDD pathway is critical for survival of HER2 (show ERBB2 Antibodies)(+) breast cancer, and possibly other malignancies, in the hypoxic tumour microenvironment

  2. data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.

  3. Data show that cichoric acid (CHA (show TCFL5 Antibodies)) is a competitive inhibitor that binds in the active site of protein tyrosine phosphatase 1B (PTP1B), and chlorogenic acid (CGA (show CGA Antibodies)), while a noncompetitive inhibitor, binds in the second aryl phosphate binding site, rather than the predicted benzfuran binding pocket.

  4. stimulation of the DOCK180 (show DOCK1 Antibodies) pathway represents an alternative mechanism of PTP1B inhibitor-stimulated endothelial cell motility, which does not require concomitant VEGFR2 (show KDR Antibodies) activation as a prerequisite.

  5. Overexpression of PTP1B is associated with breast neoplasms.

  6. The analysis revealed three candidate genes GSK3B (show GSK3b Antibodies), PTPN1, STX4 (show STX4 Antibodies) that are differentially expressed in study subjects. GSK3B (show GSK3b Antibodies) was highly significant in Ps-T2D (P=0.00018, FR=-26.6), followed by Ps (P=0.0028, FR=-14.5) and T2D groups (P=0.032, FR=-5.9). PTPN1 showed significant association only with PS-T2D (P=0.00027, FR=-8.5). STX4 (show STX4 Antibodies) showed significant association with both Ps (P=0.0002, FR=-20) and Ps-T2D (P=0.0016, FR=-11.2).

  7. LPS (show IRF6 Antibodies) tolerance interferes with TLR4 (show TLR4 Antibodies) signaling by inhibiting Lyn (show LYN Antibodies) and c-Src (show SRC Antibodies) phosphorylation and their recruitment to TLR4 (show TLR4 Antibodies), while increasing the phosphatase activity and expression of PP2A (show PPP2R4 Antibodies), PTPN22 (show PTPN22 Antibodies), PTP1B and MKP1 (show DUSP1 Antibodies).

  8. PTP1B directly regulates STAT5 (show STAT5A Antibodies) phosphorylation and its activation via the cAMP/PKA pathway downstream of the 5-HT7 (show HTR7 Antibodies) receptor is involved in the suppression of beta-casein (show CSN2 Antibodies) expression in MCF-12A cells

  9. On EGF (show EGF Antibodies) stimulation, complexes containing Mena (show EGFR Antibodies) and PTP1B are recruited to the EGFR (show EGFR Antibodies), causing receptor dephosphorylation and leading to decreased motility responses.

  10. PTP1B dephosphorylates PITX1 (show PITX1 Antibodies) to weaken its protein stability and the transcriptional activity for p120RasGAP (show RASA1 Antibodies) gene expression

Mouse (Murine) Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) interaction partners

  1. this paper shows that PTP1B specifically regulates IgE-mediated STAT5 (show STAT5A Antibodies) pathway, but is redundant in influencing mast cell function in vivo

  2. PTP1B/RNF213 (show RNF213 Antibodies)/alpha-KGDD pathway is critical for survival of HER2 (show ERBB2 Antibodies)(+) breast cancer, and possibly other malignancies, in the hypoxic tumour microenvironment

  3. data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.

  4. These findings reveal a novel role for pancreatic PTP1B in cerulein- and arginine-induced acute pancreatitis.

  5. POMC (show POMC Antibodies)-Ptp1b deletion increases plasma TNF-alpha (show TNF Antibodies) levels

  6. Data show that protein tyrosine phosphatase 1B (PTP1B)-deficiency enhanced JAK2 (show JAK2 Antibodies)-STAT3 (show STAT3 Antibodies) signaling in hypothalamic microglia and attenuated inflammation.

  7. Taken together, the data presented here suggest that PTP1B is essential for proper differentiation of ES cells into cardiomyocytes.

  8. This study demonstrates that PTP1B is an important positive regulator of neuroinflammation

  9. Cudrania tricuspidata leaves (CTe) had a strong inhibitory effect on PTP1B activity and substantially inhibited fat accumulation in 3T3-L1 cells

  10. Deletion of Ptp1b in POMC (show POMC Antibodies) neurons protects from leptin (show LEP Antibodies)- and sympatho-mediated increases in BP.

Cow (Bovine) Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) interaction partners

  1. data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.

PTPN1 Antigen Profile

Antigen Summary

The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.

Alternative names and synonyms associated with PTPN1

  • protein tyrosine phosphatase, non-receptor type 1 (PTPN1) antibody
  • protein tyrosine phosphatase, non-receptor type 1 (Ptpn1) antibody
  • protein tyrosine phosphatase, non-receptor type 1 (ptpn1) antibody
  • CPTP1 antibody
  • Ptp antibody
  • PTP-1B antibody
  • PTP-HA2 antibody
  • ptp1b antibody
  • PTPN1 antibody
  • wu:fk54h03 antibody

Protein level used designations for PTPN1

protein tyrosine phosphatase, non-receptor type 1 , tyrosine-protein phosphatase non-receptor type 1 , tyrosine-protein phosphatase non-receptor type 1-like , protein tyrosine phosphatase, placental , protein-tyrosine phosphatase 1B , protein-protein-tyrosine phosphatase HA2 , protein-tyrosine phosphatase HA2 , PTP-1B , fk54h03 , protein tyrosine phosphatase 1b , non-receptor protein tyrosine phosphatase , phosphoprotein phosphatase , tyrosine phosphatase 1B

GENE ID SPECIES
469970 Pan troglodytes
702016 Macaca mulatta
100172151 Pongo abelii
100354834 Oryctolagus cuniculus
100387823 Callithrix jacchus
100481720 Ailuropoda melanoleuca
5770 Homo sapiens
19246 Mus musculus
24697 Rattus norvegicus
30081 Danio rerio
444514 Xenopus laevis
395688 Gallus gallus
477263 Canis lupus familiaris
396667 Sus scrofa
508658 Bos taurus
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