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Human TLR3 ELISA Kit for Sandwich ELISA - ABIN1672829
Rock, Hardiman, Timans, Kastelein, Bazan: A family of human receptors structurally related to Drosophila Toll. in Proceedings of the National Academy of Sciences of the United States of America 1998
Study found TLR3 and IFNgamma to play an important role in Hepatitis E pathogenesis. Patients expressing high levels of TLR 3 and robust IFNgamma response are able to recover from the disease; while those with lower expression progress to acute liver failure.
Study clearly demonstrated that the expression of this isoform of TLR3 was a negative regulator of signaling pathways and that it was inducible by type I interferons. Authors also found that this isoform could modulate inflammation in the brain.
TLR3 polymorphisms are unlikely to play a significant role in the development of preeclampsia in the Chinese Han population.
The anti-viral effect of IL-24 (show IL24 ELISA Kits) correlated with caspase-3 (show CASP3 ELISA Kits) activation and could be blocked by a pan-caspase (show CASP3 ELISA Kits) inhibitor and by small interfering RNA (siRNA) directed towards TLR3.
role of TLR3/BAFF axis in IgA class-switch recombination of IgA nephropathy
TLR3 has a role in inducing inflammation in nasopharyngeal carcinoma through EBV-encoded RNA
Findings indicate that melanoma differentiation associated protein-5 (MDA5 (show IFIH1 ELISA Kits)) may serve as a complementary role in the toll (show TLR4 ELISA Kits)-like receptor3 (TLR3) activated suppression of neuroblastoma (show ARHGEF16 ELISA Kits) (NB).
We found that activation of TLR3 signaling could induce the expression of CXCL1 (show CXCL1 ELISA Kits) in mesangial cells
Based on the collective findings, we suggest that vIRF2 acts as an activator in PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits) pathway.
High TLR3 expression is associated with Inflammatory Bowel Disease.
The results imply that recognition of resident viruses by TLR3 and TLR7 (show TLR7 ELISA Kits) is required for protective immunity during gut (show GUSB ELISA Kits) inflammation.
TRIF (show RNF138 ELISA Kits)-independent pathways can be involved in the downregulation of drug metabolizing enzymes and transporters through TLR4 (show TLR4 ELISA Kits) and 3. JNK (show MAPK8 ELISA Kits)-dependent mechanisms likely mediate this downregulation.
Results show that toll (show TLR4 ELISA Kits)/IL-1 (show IL1A ELISA Kits) domain-containing adaptor inducing IFN-beta (show IFNB1 ELISA Kits) (TRIF (show RNF138 ELISA Kits)) is essential for Toll (show TLR4 ELISA Kits)-like receptors TLR3- and TLR4 (show TLR4 ELISA Kits)-mediated innate immune responses in peritoneal mesothelial cells (PMCs).
during Respiratory syncytial virus infection, respiratory macrophages and dendritic cells mediate the production of IL-33 (show IL33 ELISA Kits) in a TLR-dependent manner
TNFalpha (show TNF ELISA Kits)-blockade stabilizes local airway hyperresponsiveness during TLR3/4-induced exacerbations in murine model of asthma.
Shock wave treatment protects from neuronal degeneration via TLR3 signaling and subsequent TLR4 (show TLR4 ELISA Kits) downregulation in model of ischemic spinal cord injury.
The authors confirmed that the protective effect of poly I:C against enteric infection of mice with Yersinia enterocolitica was dependent on TLR3-mediated TRIF (show RNF138 ELISA Kits) signaling by using TLR3-deficient mice.
The results of the present study indicate that activation of TLR3 by PolyI:C induces the spermatogonial stem cells apoptosis, which implies that viral infection may interfere with the male germ cell development.
dsRNA and TLR3 link the earliest events of mammalian skin wounding to regeneration and suggest potential therapeutic approaches for promoting hair neogenesis.
Data indicate that calgranulin B (S100A9 (show S100A9 ELISA Kits)) is essential for in vivo toll like receptor 3 (TLR3) signaling.
These data demonstrated that TLR2 (show TLR2 ELISA Kits), TLR3 and TLR9 (show TLR9 ELISA Kits) contribute to NF-kappaB (show NFKB1 ELISA Kits) activation in response to porcine epidemic diarrhea virus infection, but not RIG-I (show DDX58 ELISA Kits).
TLR3 is regulated differentially by different genotype 1 PRRSV strains and this seems to be related apparently to the replication levels of each strain, as well as, to the TNF-alpha (show TNF ELISA Kits) inducing capability.
5 known non-synonymous single nucleotide polymorphisms (SNPs) were characterized in the coding sequences of the porcine TLR3 gene.
Activation of porcine TLR3 signaling is important in stimulating effective responses to PRRSV infection.
18 SNPs of TLR3 were observed and only 4 polymorphic positions were detected in the domestic breeds and 14 non-synonymous substitutions were observed, most of them in the LRR molecules.
Binding energy (BE) calculation using MM/PBSA method from the TLR3- and TLR22-ligand complexes revealed an adequate binding affinity between TLR22-monomer and dsRNA as like as TLR3-dimer-dsRNA complex.
Full-length tlr3 was functionally characterized.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.
toll-like receptor 3
, toll-like receptor 3-like
, toll-like receptor 3 variant 1