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anti-Human TLR5 Antibodies:
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Dog (Canine) Monoclonal TLR5 Primary Antibody for FACS, IHC (p) - ABIN4360253
Li, Younger, Gartenhaus, Joseph, Hu, Baer, Brown, Davila: Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies. in The Journal of clinical investigation 2015
Show all 25 Pubmed References
Dog (Canine) Monoclonal TLR5 Primary Antibody for FACS, IHC - ABIN4360264
Smith, Varley, Eardley, Feather, Trejdosiewicz, Southgate: Toll-like receptor responses of normal human urothelial cells to bacterial flagellin and lipopolysaccharide. in The Journal of urology 2011
Show all 24 Pubmed References
Dog (Canine) Monoclonal TLR5 Primary Antibody for FACS - ABIN268286
Mansson, Adner, Cardell: Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitis. in Respiratory research 2006
Show all 16 Pubmed References
Dog (Canine) Monoclonal TLR5 Primary Antibody for FACS - ABIN4360267
Crellin, Garcia, Hadisfar, Allan, Steiner, Levings: Human CD4+ T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4+CD25+ T regulatory cells. in Journal of immunology (Baltimore, Md. : 1950) 2005
Show all 15 Pubmed References
Dog (Canine) Monoclonal TLR5 Primary Antibody for FACS - ABIN4360262
Kato, Lillehoj, Park, Umehara, Hoffman, Madesh, Kim: Membrane-tethered MUC1 mucin is phosphorylated by epidermal growth factor receptor in airway epithelial cells and associates with TLR5 to inhibit recruitment of MyD88. in Journal of immunology (Baltimore, Md. : 1950) 2012
Show all 15 Pubmed References
Dog (Canine) Monoclonal TLR5 Primary Antibody for FACS - ABIN4360261
Fukata, Breglio, Chen, Vamadevan, Goo, Hsu, Conduah, Xu, Abreu: The myeloid differentiation factor 88 (MyD88) is required for CD4+ T cell effector function in a murine model of inflammatory bowel disease. in Journal of immunology (Baltimore, Md. : 1950) 2008
Show all 12 Pubmed References
Human Polyclonal TLR5 Primary Antibody for FACS, IHC (p) - ABIN4360266
Brandon, Perez, Jennings, Cohen, Sindhava, Bondada, Kaplan, Bryson: Association between chronic liver and colon inflammation during the development of murine syngeneic graft-versus-host disease. in American journal of physiology. Gastrointestinal and liver physiology 2010
Show all 7 Pubmed References
Human Polyclonal TLR5 Primary Antibody for WB - ABIN550253
Takeda, Kaisho, Akira: Toll-like receptors. in Annual review of immunology 2003
Show all 3 Pubmed References
Human Polyclonal TLR5 Primary Antibody for IF (p), IHC (p) - ABIN673239
Hao, Zhang, Liang, Song, Hou: rFliC prolongs allograft survival in association with the activation of recipient Tregs in a TLR5-dependent manner. in Cellular & molecular immunology 2014
Show all 3 Pubmed References
Human Polyclonal TLR5 Primary Antibody for IF, WB - ABIN550252
Hayashi, Smith, Ozinsky, Hawn, Yi, Goodlett, Eng, Akira, Underhill, Aderem: The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. in Nature 2001
Show all 2 Pubmed References
Both HEK293 (human origin) and embryonic bovine lung cells transfected with bTLR5 responded to addition of H7 flagellin (show FliC Antibodies). Responses were significantly reduced when mutations were introduced into the TLR5-binding regions of H7 flagellin (show FliC Antibodies).
TLR 5, 7, and 9 expression patterns differed between HPV-positive and -negative oropharyngeal squamous cell carcinoma patients. In HPV-positive tumors the expression of TLR 5 and 7 correlated with tumor recurrence.
These results suggest that HMGB1 (show HMGB1 Antibodies)-modulated TLR5 signaling is responsible for pain hypersensitivity.
data show that TLR-5 and TLR-9 (show TLR9 Antibodies) are susceptible genes to lupus nephritis (LN) and that their expression is dysregulated in LN patients' kidneys, supporting a role of these mediators in the pathogenesis of LN.
These results indicate that in Chinese genetic variation of TLR5 may be not a determinant of susceptibility to hepatitis B virus-related diseases but may play a role in development of hepatitis B virus-related severe liver diseases.
Distinctive Recognition of Flagellin (show FliC Antibodies) by Human and Mouse Toll-Like Receptor 5
This study independently confirms the association of TLR5 c.1174C>T with protection against death in melioidosis, identifies lower bacteremia, IL-10 (show IL10 Antibodies) and TNF-alpha (show TNF Antibodies) production in carriers of the variant with melioidosis.
Study demonstrated that toll-like receptor 5 expression and functional activity as measured by interleukin 6 (show IL6 Antibodies) are modulated by hormones
findings suggest that TLR5 is functionally expressed in the SG and responds to its cognate ligand flagellin (show FliC Antibodies)
Upregulation of TLR4 (show TLR4 Antibodies), TLR5, and TLR9 (show TLR9 Antibodies) suggests the involvement of bacteria or dysregulation of the immune response to commensal flora in small bowel mucosa in irritable bowel syndrome patients.
that TLR5 is involved in the pathogenesis and dissemination of esophageal adenocarcinoma through as-yet-uncharacterized mechanisms
data directly demonstrate that nasal epithelial GM-CSF contributes to TLR5-mediated modulation of airway DCs and a subsequent IgA response.
The activation of NLRC4 (show NLRC4 Antibodies) by flagellin (show FliC Antibodies) downregulated the flagellin (show FliC Antibodies)-induced and TLR5-mediated immune responses against flagellin (show FliC Antibodies).
TLR5 but not NLRC4 (show NLRC4 Antibodies) is required for S. pneumoniae FliC (show FliC Antibodies)-induced protection.
This resulted in Sp1 (show SP1 Antibodies) displacement from the promoter and binding of Sp3 (show SP3 Antibodies) to it, leading to p300 (show NOTCH1 Antibodies) recruitment and histone acetylation, activating transcription. This is the first study addressing the mechanisms of physiological TLR5 expression in the intestine. Additionally, a novel insight is gained into Sp1 (show SP1 Antibodies)/Sp3 (show SP3 Antibodies)-mediated gene regulation that may apply to other genes
TLR5 mediates CD172a (show SIRPA Antibodies)(+) intestinal lamina propria dendritic cell induction of Th17 cells.
TLR5 activation plays an important role in the induction of podocyte apoptosis
TLR5 gene knockout impairs some effects of weight-reduction in diet-induced obesity (DIO). The glucose intolerance in DIO TLR5(-/-) mice was more significant than that in DIO C57BL/6 mice.
The results suggest that caveolin-1 (show CAV1 Antibodies)/TLR5 signaling plays a key role in age-associated innate immune responses and that FlaB (show FliC Antibodies)-PspA (show SFTPA1 Antibodies) stimulation of TLR5 may be a new strategy for a mucosal vaccine adjuvant against pneumococcal infection in the elderly.
This study identified variations in the promoter that resulted in changes in TLR5 gene expression.
TLR5 takes part in the airway mucosal defense systems as a unique endogenous potentiator of airway serous secretions.
The results indicated that TLR5 SNPs were associated with the transcript abundance of cytokines.
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.
toll-like receptor 5
, toll/interleukin-1 receptor-like protein 3