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Human TLR5 ELISA Kit for Sandwich ELISA - ABIN417427
Yang, Xie, Deng, Qin: Expression of soluble Toll-like receptors in pleural effusions. in Chinese medical journal 2010
Both HEK293 (human origin) and embryonic bovine lung cells transfected with bTLR5 responded to addition of H7 flagellin (show FliC ELISA Kits). Responses were significantly reduced when mutations were introduced into the TLR5-binding regions of H7 flagellin (show FliC ELISA Kits).
These results indicate that in Chinese genetic variation of TLR5 may be not a determinant of susceptibility to hepatitis B virus-related diseases but may play a role in development of hepatitis B virus-related severe liver diseases.
Distinctive Recognition of Flagellin (show FliC ELISA Kits) by Human and Mouse Toll-Like Receptor 5
This study independently confirms the association of TLR5 c.1174C>T with protection against death in melioidosis, identifies lower bacteremia, IL-10 (show IL10 ELISA Kits) and TNF-alpha (show TNF ELISA Kits) production in carriers of the variant with melioidosis.
Study demonstrated that toll-like receptor 5 expression and functional activity as measured by interleukin 6 (show IL6 ELISA Kits) are modulated by hormones
findings suggest that TLR5 is functionally expressed in the SG and responds to its cognate ligand flagellin (show FliC ELISA Kits)
Upregulation of TLR4 (show TLR4 ELISA Kits), TLR5, and TLR9 (show TLR9 ELISA Kits) suggests the involvement of bacteria or dysregulation of the immune response to commensal flora in small bowel mucosa in irritable bowel syndrome patients.
that TLR5 is involved in the pathogenesis and dissemination of esophageal adenocarcinoma through as-yet-uncharacterized mechanisms
Ligands for TLR1 (show TLR1 ELISA Kits)/2 or TLR5 may provide critical stimuli able to sustain the growth and the malignant phenotype of MCL (show FH ELISA Kits) cells.
The distribution of the TLR 5 genotypes did not differ significantly between bronchopulmonary dysplasia patients and controls.
Both TLR 5 and 7 are expressed in salivary adenoid cystic carcinoma on the cell membranes as well as in cytoplasm.
data directly demonstrate that nasal epithelial GM-CSF contributes to TLR5-mediated modulation of airway DCs and a subsequent IgA response.
The activation of NLRC4 (show NLRC4 ELISA Kits) by flagellin (show FliC ELISA Kits) downregulated the flagellin (show FliC ELISA Kits)-induced and TLR5-mediated immune responses against flagellin (show FliC ELISA Kits).
TLR5 but not NLRC4 (show NLRC4 ELISA Kits) is required for S. pneumoniae FliC (show FliC ELISA Kits)-induced protection.
This resulted in Sp1 (show SP1 ELISA Kits) displacement from the promoter and binding of Sp3 (show SP3 ELISA Kits) to it, leading to p300 (show NOTCH1 ELISA Kits) recruitment and histone acetylation, activating transcription. This is the first study addressing the mechanisms of physiological TLR5 expression in the intestine. Additionally, a novel insight is gained into Sp1 (show SP1 ELISA Kits)/Sp3 (show SP3 ELISA Kits)-mediated gene regulation that may apply to other genes
TLR5 mediates CD172a (show SIRPA ELISA Kits)(+) intestinal lamina propria dendritic cell induction of Th17 cells.
TLR5 activation plays an important role in the induction of podocyte apoptosis
TLR5 gene knockout impairs some effects of weight-reduction in diet-induced obesity (DIO). The glucose intolerance in DIO TLR5(-/-) mice was more significant than that in DIO C57BL/6 mice.
The results suggest that caveolin-1 (show CAV1 ELISA Kits)/TLR5 signaling plays a key role in age-associated innate immune responses and that FlaB (show FliC ELISA Kits)-PspA (show SFTPA1 ELISA Kits) stimulation of TLR5 may be a new strategy for a mucosal vaccine adjuvant against pneumococcal infection in the elderly.
Over-activation of TLR5 signaling by high-dose flagellin (show FliC ELISA Kits) induces liver injury in mice.
This study identified variations in the promoter that resulted in changes in TLR5 gene expression.
TLR5 takes part in the airway mucosal defense systems as a unique endogenous potentiator of airway serous secretions.
The results indicated that TLR5 SNPs were associated with the transcript abundance of cytokines.
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.
toll-like receptor 5
, toll/interleukin-1 receptor-like protein 3