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Identified human TLR8 as functional TLR13 (show Tlr13 Proteins) equivalent that promiscuously senses ssRNA.
TLR8 polymorphisms seem to be related to non-progression of liver fibrosis in HIV/HCV coinfected patients, particularly in males and those patients infected with GT1 (show B4GALT1 Proteins).
TLR8 with the uncleaved Z-loop is unable to form a dimer. The uncleaved Z-loop located on the ascending lateral face prevents the approach of the dimerization partner by steric hindrance.
TLR7 (show TLR7 Proteins) and 8 polymorphisms may play a considerable role in the pathogenesis of asthma.
Results show that TLR7 (show TLR7 Proteins) and TLR8 on trophoblastic cells play an important role in the prevention of intrauterine HBV transmission by inhibiting HBV translocation across trophoblasts.
Study show a stage-dependent upregulation of both TLR7 (show TLR7 Proteins) and TLR8 expression in pancreatic cancer and point to their significant role in chronic inflammation-mediated TLR7 (show TLR7 Proteins)/TLR8 signaling leading to tumor cell proliferation and chemoresistance.
Sex-specific associations for TLR8 polymorphisms in tuberculosis.
Knockdown of LRRC59 reduced TLR3 (show TLR3 Proteins)-, 8-, and 9-mediated, but not TLR4 (show TLR4 Proteins)-mediated, signaling.
an important role of 2'-O-methylation for shaping differential TLR7 (show TLR7 Proteins) or TLR8 activation
the activation of TLR8 by bi-specific si-RNA for the production of INFbeta, was investigated.
Hepatic expression of Tlr6 (show TLR6 Proteins), but not that of Tlr8 is epigenetically controlled, and that the dysregulations of Tlr6 (show TLR6 Proteins) and Tlr8 critically contribute to Testosterone (T)-induced persistent susceptibility to P. chabaudi malaria.
The urinary levels of Tlr8 mRNA were also higher in BXSB-Yaa mice.
TLR8 deletion accelerated autoimmunity in lupus-prone mice in response to TLR7 (show TLR7 Proteins) activation.
TLR8 activation has direct anti-leukemic effects independent of its immunomodulating properties.
We suggest that giant cell formation may be a unique feature of TLR9 (show TLR9 Proteins)- and TLR7 (show TLR7 Proteins)/8-mediated macrophage activation.
These results suggest that IL-23 (show IL23A Proteins)-driven inflammation in mouse skin may be dependent on signaling mediated by TLRs 7, 8, and 9
aortic angiogenesis is preceded by an immune reaction with overexpression of Toll (show TLR4 Proteins)-like receptors (TLRs) and TLR-inducible genes.
Dosage of X-linked Toll-like receptor 8 determines gender differences in the development of systemic lupus erythematosus.
MSCs and MSC (show MSC Proteins)-conditioned medium modulate the cytokine expression profile in macrophages following TLR7 (show TLR7 Proteins)/8-mediated stimulation, which suggests that MSCs play an immunomodulatory role during ssRNA virus infection
A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition.
a ligand-induced dimer conformational switch is mainly responsible for TLR8 activation.
multiple regions, including ECD (show ECD Proteins), TM, linker and TIR-tail regions of bTLR8, are involved in determining the localization of cellular ER compartment.
Porcine TLR7 (show TLR7 Proteins) and TLR8 genes from pig lymph node tissue, were cloned and characterized.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.