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Demonstrate STAT1 (show STAT1 Proteins)-dependent transcriptional activation of TLR8 with estrogen stimulation.
TLR8 gene rs3764880 polymorphisms might be associated with susceptibility to ischemic stroke and involved in the inflammatory reaction and lipid metabolism of ischemic stroke in southern Chinese Han.
TLR8 polymorphisms were associated with an increased risk and TLR7 (show TLR7 Proteins) polymorphisms with a decreased risk of recurrent rhinovirus infections.
interferon alpha (IFN-alpha (show IFNA Proteins)) secretion induced by Toll-like receptor 7 (show TLR7 Proteins) and Toll-like receptor 8 (TLR7 (show TLR7 Proteins)/TLR8) activation was observed in common variable immunodeficiency (CVID (show TNFRSF13B Proteins)), which was recovered with Toll-like receptor 9 (TLR9 (show TLR9 Proteins)) signaling.
this study shows that TLR8 gene polymorphism is associated with susceptibility to HIV and HCV co-infection
Our meta-analysis suggests that TLR7 (show TLR7 Proteins), TLR8, and TLR9 (show TLR9 Proteins) polymorphisms are associated with the development of systemic lupus erythematosus in Caucasian, Asian, and African populations
Comparison of present and previous association studies reveals contradictory results for common variants. Thus, no associations exist between genetic variation in TLR8 and AR.
Identified human TLR8 as functional TLR13 (show Tlr13 Proteins) equivalent that promiscuously senses ssRNA.
TLR8 polymorphisms seem to be related to non-progression of liver fibrosis in HIV/HCV coinfected patients, particularly in males and those patients infected with GT1 (show B4GALT1 Proteins).
TLR8 with the uncleaved Z-loop is unable to form a dimer. The uncleaved Z-loop located on the ascending lateral face prevents the approach of the dimerization partner by steric hindrance.
this study shows that beta,beta-dimethylacryloyl alkannin could inhibit psoriasis-activated dendritic cells via the TLR7 (show TLR7 Proteins)/8 pathway
an important role of 2'-O-methylation for shaping differential TLR7 (show TLR7 Proteins) or TLR8 activation
Hepatic expression of Tlr6 (show TLR6 Proteins), but not that of Tlr8 is epigenetically controlled, and that the dysregulations of Tlr6 (show TLR6 Proteins) and Tlr8 critically contribute to Testosterone (T)-induced persistent susceptibility to P. chabaudi malaria.
The urinary levels of Tlr8 mRNA were also higher in BXSB-Yaa mice.
TLR8 deletion accelerated autoimmunity in lupus-prone mice in response to TLR7 (show TLR7 Proteins) activation.
TLR8 activation has direct anti-leukemic effects independent of its immunomodulating properties.
We suggest that giant cell formation may be a unique feature of TLR9 (show TLR9 Proteins)- and TLR7 (show TLR7 Proteins)/8-mediated macrophage activation.
These results suggest that IL-23 (show IL23A Proteins)-driven inflammation in mouse skin may be dependent on signaling mediated by TLRs 7, 8, and 9
aortic angiogenesis is preceded by an immune reaction with overexpression of Toll (show TLR4 Proteins)-like receptors (TLRs) and TLR-inducible genes.
Dosage of X-linked Toll-like receptor 8 determines gender differences in the development of systemic lupus erythematosus.
The results from this study demonstrate that expression of at least TLR3 (show TLR3 Proteins), TLR7 (show TLR7 Proteins) and TLR8 is stimulated upon bovine alpha-herpesvirus infection of the brain.
Knockdown TLR8 increased the apoptosis induced by Bacillus Calmette Guerin infection, and this enhanced apoptosis was caspase (show CASP3 Proteins)-dependent.
A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition.
a ligand-induced dimer conformational switch is mainly responsible for TLR8 activation.
multiple regions, including ECD (show ECD Proteins), TM, linker and TIR-tail regions of bTLR8, are involved in determining the localization of cellular ER compartment.
Porcine TLR7 (show TLR7 Proteins) and TLR8 genes from pig lymph node tissue, were cloned and characterized.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.