Browse our TLR8 Proteins (TLR8)

Full name:
Toll-Like Receptor 8 Proteins (TLR8)
On are 17 Toll-Like Receptor 8 (TLR8) Proteins from 5 different suppliers available. Additionally we are shipping TLR8 Antibodies (263) and TLR8 Kits (19) and many more products for this protein. A total of 310 TLR8 products are currently listed.
list all proteins Gene Name GeneID UniProt
TLR8 51311 Q9NR97
TLR8 170744 P58682
TLR8 684440  

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TLR8 Proteins (TLR8) by Origin

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More Proteins for TLR8 Interaction Partners

Human Toll-Like Receptor 8 (TLR8) interaction partners

  1. Data indicate a mechanism in which Toll (show TLR4 Proteins)-like receptors TLR7 (show TLR7 Proteins)/8 signaling, through shedding of FcgRIIA, shifts neutrophil function from phagocytosis to a programmed necrosis pathway, neutrophil extracellular trap formation (NETosis).

  2. this study identified TLR8 as mediator of monocyte differentiation and M2 macrophage polarization during hepatitis C virus infection

  3. COPD (show ARCN1 Proteins) lung tissue explants showed a greater pro-inflammatory response to TLR3 (show TLR3 Proteins) or TLR7 (show TLR7 Proteins)/8 activation than control smokers.

  4. combination adjuvant systems demonstrate markedly different immune activation with age, with combined DC activation via Macrophage-inducible C-type lectin (show CLEC4E Proteins) and TLR7 (show TLR7 Proteins)/8 representing a novel approach to enhance the efficacy of early-life vaccines.

  5. Demonstrate STAT1 (show STAT1 Proteins)-dependent transcriptional activation of TLR8 with estrogen stimulation.

  6. TLR8 gene rs3764880 polymorphisms might be associated with susceptibility to ischemic stroke and involved in the inflammatory reaction and lipid metabolism of ischemic stroke in southern Chinese Han.

  7. TLR8 polymorphisms were associated with an increased risk and TLR7 (show TLR7 Proteins) polymorphisms with a decreased risk of recurrent rhinovirus infections.

  8. interferon alpha (IFN-alpha (show IFNA Proteins)) secretion induced by Toll-like receptor 7 (show TLR7 Proteins) and Toll-like receptor 8 (TLR7 (show TLR7 Proteins)/TLR8) activation was observed in common variable immunodeficiency (CVID (show TNFRSF13B Proteins)), which was recovered with Toll-like receptor 9 (TLR9 (show TLR9 Proteins)) signaling.

  9. this study shows that TLR8 gene polymorphism is associated with susceptibility to HIV and HCV co-infection

  10. Our meta-analysis suggests that TLR7 (show TLR7 Proteins), TLR8, and TLR9 (show TLR9 Proteins) polymorphisms are associated with the development of systemic lupus erythematosus in Caucasian, Asian, and African populations

Mouse (Murine) Toll-Like Receptor 8 (TLR8) interaction partners

  1. TLR8 coupling with SOCS-1 (show SOCS1 Proteins) inhibits TLR7 (show TLR7 Proteins)-mediated antiviral immunity during WNV infection in mice.

  2. this study shows that beta,beta-dimethylacryloyl alkannin could inhibit psoriasis-activated dendritic cells via the TLR7 (show TLR7 Proteins)/8 pathway

  3. an important role of 2'-O-methylation for shaping differential TLR7 (show TLR7 Proteins) or TLR8 activation

  4. Hepatic expression of Tlr6 (show TLR6 Proteins), but not that of Tlr8 is epigenetically controlled, and that the dysregulations of Tlr6 (show TLR6 Proteins) and Tlr8 critically contribute to Testosterone (T)-induced persistent susceptibility to P. chabaudi malaria.

  5. The urinary levels of Tlr8 mRNA were also higher in BXSB-Yaa mice.

  6. TLR8 deletion accelerated autoimmunity in lupus-prone mice in response to TLR7 (show TLR7 Proteins) activation.

  7. TLR8 activation has direct anti-leukemic effects independent of its immunomodulating properties.

  8. We suggest that giant cell formation may be a unique feature of TLR9 (show TLR9 Proteins)- and TLR7 (show TLR7 Proteins)/8-mediated macrophage activation.

  9. These results suggest that IL-23 (show IL23A Proteins)-driven inflammation in mouse skin may be dependent on signaling mediated by TLRs 7, 8, and 9

  10. aortic angiogenesis is preceded by an immune reaction with overexpression of Toll (show TLR4 Proteins)-like receptors (TLRs) and TLR-inducible genes.

Cow (Bovine) Toll-Like Receptor 8 (TLR8) interaction partners

  1. The results from this study demonstrate that expression of at least TLR3 (show TLR3 Proteins), TLR7 (show TLR7 Proteins) and TLR8 is stimulated upon bovine alpha-herpesvirus infection of the brain.

  2. Knockdown TLR8 increased the apoptosis induced by Bacillus Calmette Guerin infection, and this enhanced apoptosis was caspase (show CASP3 Proteins)-dependent.

  3. A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition.

  4. a ligand-induced dimer conformational switch is mainly responsible for TLR8 activation.

  5. multiple regions, including ECD (show ECD Proteins), TM, linker and TIR-tail regions of bTLR8, are involved in determining the localization of cellular ER compartment.

Pig (Porcine) Toll-Like Receptor 8 (TLR8) interaction partners

  1. Porcine TLR7 (show TLR7 Proteins) and TLR8 genes from pig lymph node tissue, were cloned and characterized.

Rabbit Toll-Like Receptor 8 (TLR8) interaction partners

  1. TLR2, 3, 4, and 8 mRNA expression is strongly upregulated and correlates with the progression of atherosclerosis in the aorta. Fluvastatin significantly inhibited this progress and reduced inflammation via TLR downregulation.

TLR8 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.

Alternative names and synonyms associated with TLR8

  • toll-like receptor 8 (TLR8)
  • toll-like receptor 8 (Tlr8)
  • CD288 protein
51311 Homo sapiens
170744 Mus musculus
684440 Rattus norvegicus
532262 Bos taurus
100684828 Canis lupus familiaris
100860909 Capra hircus
100713058 Cavia porcellus
397384 Sus scrofa
100328930 Oryctolagus cuniculus
554259 Ovis aries
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