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Human TLR9 Protein expressed in Wheat germ - ABIN1330558
Julian, Shao, Vangundy, Papenfuss, Crouser: Mitochondrial transcription factor A, an endogenous danger signal, promotes TNF? release via RAGE- and TLR9-responsive plasmacytoid dendritic cells. in PLoS ONE 2013
This study evaluation the roles of SOCS1 (show SOCS1 Proteins), the regulator of TLR9, RIG-I (show DDX58 Proteins), and CD152 (show CTLA4 Proteins) in patients with liver fibrosis/cirrhosis; the use of polymorphisms as markers for genetic risk is reported.
cathelicidin selectively modulated synthesis of TLR4 (show TLR4 Proteins) and 9 in intestinal epithelium, but only when cells were exposed to virulence factors, mostly from apical surfaces.
Tumor TLR9 expression is not associated with prognosis in African American triple negative breast cancer . Significant differences were detected in TLR9 variant MAFs between European Americans and African American . They may affect TLR9 expression and function.
Early endosomal TLR9 activation is important for MR1 (show MR1 Proteins)-mediated bacterial antigen presentation in B cells.
This study provides new insight into the mechanism that mediates TLR9 upregulation in response to cellular stresses. In addition, it shows that HPV38 E6 and E7 are able to interfere with this mechanism.
In conclusion, our data provide strong indirect evidence that TLR9 might play a greater role in HCV infection than previously expected. We identified an association of the polymorphism rs187084 within the TLR9 gene with the natural course of HCV infection in women.
this study shows that the double CpG motif sequence-specificity of human TLR9 results in decreased activation by oligodeoxyribonucleotides
Patients with low TLR9 expression have longer survival rates with supratentorial glioblastoma compared to patients with higher expression rates.
The effect could be blocked by chloroquine (CQ), a TLR9 inhibitor.
mechanism integrating BCR, TLR9, and cytokine signals provides a peripheral checkpoint for DNA-containing antigens that, if circumvented by survival and differentiative cues, yields B cells with the autoimmune-associated T-bet+ phenotype.
High-glucose induces tau hyperphosphorylation through activation of TLR9-P38 MAPK (show MAPK14 Proteins) pathway.
proposed that TLR9 regulates the NF-kappaB (show NFKB1 Proteins)-NLRP3 (show NLRP3 Proteins)-IL-1beta (show IL1B Proteins) pathway negatively in Salmonella-induced NKG2D (show KLRK1 Proteins)-mediated intestinal inflammation and plays a critical role in defense against S. typhimurium infection and in the protection of intestinal integrity.
we demonstrated for the first time that the cross-talk of TLR2 and TLR9 triggered Th1 (show HAND1 Proteins) activation collaboratively
the cooperative role of TLR9 with TLR2 or TLR6 (show TLR6 Proteins) receptors in sensing Brucella, was determined.
accelerating effects of Tlr9 deficiency
Increased circulating mtDNA combined with upregulated TLR9 expression may corporately play a role in EAM as well as TLR4 (show TLR4 Proteins) activation mediated cardiac inflammation and injury
Data show that inoculating mice deficient in toll (show TLR4 Proteins)-like receptors TLR4 (show TLR4 Proteins) or TLR9 with LPS (show TLR4 Proteins) or CpG-stimulated eosinophils, NK cell recruitment was observed alongside cytotoxicity.
Significantly lower levels of interferon (show IFNA Proteins)-stimulated gene expression in response to purified curli-DNA in TLR2 and TLR9 deficient mice compared to wild-type mice.
these data provide a new perspective on the complexity of TLR9 regulation by proteolytic cleavage
TLR9 immunoreactivity is mainly detected in epithelial cells and antigen presenting cells, namely dendritic and macrophage-like cells, within the range of tissues examined. The pattern of TLR9 expression was similar in pigs of 3 weeks and 3 months of age.
These data demonstrated that TLR2, TLR3 (show TLR3 Proteins) and TLR9 contribute to NF-kappaB (show NFKB1 Proteins) activation in response to porcine epidemic diarrhea virus infection, but not RIG-I (show DDX58 Proteins).
expression of TLR3 (show TLR3 Proteins), TLR7 (show TLR7 Proteins) and TLR9 in alveolar macrophages infected with different genotype 1 PRRSV strains
we studied TLR9 expression in lung extracts from pigs, dogs, and cattle.
Moreover, the TLR9 transfectant demonstrated its usefulness for evaluation of immunostimulation by bacterial DNA through the detection of T(H)-1, T(H)-2 type cytokine induction via TLR9 signaling.
variants in the TLR1 (show TLR1 Proteins) gene are associated with susceptibility to bovine tuberculosis, whereas no significant association can be inferred from the polymorphisms in the TLR9 gene
mRNA abundances of TLR9, TLR2, and TLR4 (show TLR4 Proteins) together with those of beta-defensin 5 (BNBD5 (show DEFB105A Proteins)), an early bactericidal effector molecule of the innate system, in healthy and infected mammary glands
substantial conservation of TLR9 structure and TLR9 function in blood leukocytes
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.
Toll-like receptor 9 protein