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Human TLR9 Protein expressed in Wheat germ - ABIN1330558
Julian, Shao, Vangundy, Papenfuss, Crouser: Mitochondrial transcription factor A, an endogenous danger signal, promotes TNF? release via RAGE- and TLR9-responsive plasmacytoid dendritic cells. in PLoS ONE 2013
These findings demonstrate differential reaction of cholinesterase-targeting miRNAs to distinct TLR9 challenges, indicating upstream miRNA co-regulation of the intestinal alternative NFkappaB pathway and cholinergic signaling.
Toll-like receptor 9 mediates OTSCC invasion and migration in vitro and is an independent prognostic factor of OTSCC.
no association between genetic polymorphism the hyper-IgE syndrome phenotype
Report increased TLR9 expression in endosomes from patients with metabolic syndrome.
clinical outcome in malaria was observed to be apparently modulated by LD between TLR9 promoter variants.
IRF5 (show IRF5 Proteins) and IRF8 (show IRF8 Proteins), two transcription factors with opposing functions, control TLR9 signaling in human plasmacytoid dendritic cells.
activated ARF3 (show ARF3 Proteins) is associated with Unc93B1 and TLR9, suggesting that ARF3 (show ARF3 Proteins) conducts TLR9 trafficking by forming the TLR9-Unc93B1-ARF3 (show ARF3 Proteins) complex.
NADPH oxidase (show NOX1 Proteins)-deficient patient-derived B cells also expressed enhanced levels of TLR7 (show TLR7 Proteins) and TLR9 mRNA and protein compared with the same cells reconstituted to restore oxidase activity.
Data show that differences in codon bias limit Toll-like receptor 7 (TLR7 (show TLR7 Proteins)) expression relative to Toll-like receptor 9 (TLR9).
Results indicate that heterodimerization of GCA (show NPR1 Proteins) and TLR9 is important for TLR9-mediated downstream signaling and might serve to fine tune processes against viral infection.
In mice, nonalcoholic steatohepatitis development in response to a high-fat diet required TLR9 on lysozyme (show LYZ Proteins)-expressing cells
TLR9 activation at high and low CpG ODN concentrations has roles in acute and chronic vascular injury in mice
The current study demonstrates for the first time an immunomodulatory role for TLR9 in acute kidney injury by enhancing the capacity of Tregs to migrate to damaged tissue in a model of common and relevant kidney disease.
recognition of beta-1,3 glucan by Dectin-1 (show CLEC7A Proteins) triggers TLR9 trafficking to beta-1,3 glucan-containing phagosomes, which may be critical in coordinating innate antifungal defense.
Sustained activation of Toll-like receptor 9 causes cardiac and systemic inflammation, and deterioration of SERCA2a (show ATP2A2 Proteins) depletion-mediated diastolic heart failure.
TLR9 signaling is involved in regulating adipose tissue inflammation and controlling obesity and the metabolic syndrome.
Genetic deletion of MyD88 (show MYD88 Proteins), TLR2 or TLR9 effectively controlled the signs of intestinal injury when compared with irinotecan-administered WT controls
AP-3 (show AP3B1 Proteins) recruitment to TLR9 endosomes was impaired by PIKfyve (show PIKFYVE Proteins) inhibition.
TLR9 immunoreactivity is mainly detected in epithelial cells and antigen presenting cells, namely dendritic and macrophage-like cells, within the range of tissues examined. The pattern of TLR9 expression was similar in pigs of 3 weeks and 3 months of age.
These data demonstrated that TLR2, TLR3 (show TLR3 Proteins) and TLR9 contribute to NF-kappaB (show NFKB1 Proteins) activation in response to porcine epidemic diarrhea virus infection, but not RIG-I (show DDX58 Proteins).
expression of TLR3 (show TLR3 Proteins), TLR7 (show TLR7 Proteins) and TLR9 in alveolar macrophages infected with different genotype 1 PRRSV strains
we studied TLR9 expression in lung extracts from pigs, dogs, and cattle.
Moreover, the TLR9 transfectant demonstrated its usefulness for evaluation of immunostimulation by bacterial DNA through the detection of T(H)-1, T(H)-2 type cytokine induction via TLR9 signaling.
variants in the TLR1 (show TLR1 Proteins) gene are associated with susceptibility to bovine tuberculosis, whereas no significant association can be inferred from the polymorphisms in the TLR9 gene
mRNA abundances of TLR9, TLR2, and TLR4 together with those of beta-defensin 5 (BNBD5), an early bactericidal effector molecule of the innate system, in healthy and infected mammary glands
substantial conservation of TLR9 structure and TLR9 function in blood leukocytes
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.
Toll-like receptor 9 protein