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Human TLR9 Protein expressed in Wheat germ - ABIN1330558
Julian, Shao, Vangundy, Papenfuss, Crouser: Mitochondrial transcription factor A, an endogenous danger signal, promotes TNF? release via RAGE- and TLR9-responsive plasmacytoid dendritic cells. in PLoS ONE 2013
sickle red blood cell induced TLR9, NLRP3 (show NLRP3 Proteins), Caspase-1 (show CASP1 Proteins), IL-1beta (show IL1B Proteins) and IL-18 (show IL18 Proteins) expression and induced IL-1beta (show IL1B Proteins), LTB4 (show PTGR1 Proteins) and nitrite production in PBMC cultures.
Findings indicate that genotype TT in the -1486 locus of the TLR9 gene could comprise a risk genotype for HPV infection, squamous intraepithelial cervical lesion, and uterine cervical neoplasm in Mexican female population.
data show that TLR-5 (show TLR5 Proteins) and TLR-9 are susceptible genes to lupus nephritis (LN) and that their expression is dysregulated in LN patients' kidneys, supporting a role of these mediators in the pathogenesis of LN.
By CRISPR/Cas9-induced inactivation of TLR9, MyD88 (show MYD88 Proteins), IRAK4 (show IRAK4 Proteins) and IRAK1 (show IRAK1 Proteins) we confirm that BZLF1 repression is dependent on functional TLR9 and MyD88 (show MYD88 Proteins) signaling, and identify IRAK4 (show IRAK4 Proteins) as an essential element for TLR9-induced repression of BZLF1 expression upon BCR (show BCR Proteins) cross-linking
results imply that TLR9-mediated activation of B-cells not only promotes cell survival, but may via p53 (show TP53 Proteins) provide cells with a barrier against harmful consequences of enhanced activation and proliferation
mutually exclusive transcriptional regulation by AP-1 (cjun (show JUN Proteins)/cfos) and non-canonical NF-kappaB (show NFKB1 Proteins) (RelB (show RELB Proteins)/p52 (show FKBP4 Proteins)) downstream of MEK (show MAP2K1 Proteins)-ERK (show EPHB2 Proteins) and NIK (show MAP3K14 Proteins)-IKK-alpha (show CHUK Proteins)-NF-kappaB2 (p100 (show CUX1 Proteins)) phosphorylation, respectively was responsible for persistent Ccl20 (show CCL20 Proteins) expression in the colonic cells.
This study evaluation the roles of SOCS1 (show SOCS1 Proteins), the regulator of TLR9, RIG-I (show DDX58 Proteins), and CD152 (show CTLA4 Proteins) in patients with liver fibrosis/cirrhosis; the use of polymorphisms as markers for genetic risk is reported.
cathelicidin selectively modulated synthesis of TLR4 (show TLR4 Proteins) and 9 in intestinal epithelium, but only when cells were exposed to virulence factors, mostly from apical surfaces.
Tumor TLR9 expression is not associated with prognosis in African American triple negative breast cancer . Significant differences were detected in TLR9 variant MAFs between European Americans and African American . They may affect TLR9 expression and function.
Early endosomal TLR9 activation is important for MR1 (show MR1 Proteins)-mediated bacterial antigen presentation in B cells.
TLR9 expression on B1a cells is not critical for their IgM-dependent atheroprotection.
This study establishes a correlation between TLR-3 (show TLR3 Proteins) and TLR-9 expression with the development of EAE. In addition, evidence of a role for the myelin peptide in targeting the innate inflammatory response to the CNS is presented.
these data demonstrate that TLR7 (show TLR7 Proteins)/TLR9 ligands push the macrophage into a phagocytic long-lived cell, with a decreased capacity of antigen presentation and reminiscent of the M2 polarized state.
TLR9/MyD88 (show MYD88 Proteins) signaling selectively in CD11c (show ITGAX Proteins)(+) dendritic cells (DCs) strongly enhances murine cytomegalovirus clearance.
High-glucose induces tau hyperphosphorylation through activation of TLR9-P38 MAPK (show MAPK14 Proteins) pathway.
proposed that TLR9 regulates the NF-kappaB (show NFKB1 Proteins)-NLRP3 (show NLRP3 Proteins)-IL-1beta (show IL1B Proteins) pathway negatively in Salmonella-induced NKG2D (show KLRK1 Proteins)-mediated intestinal inflammation and plays a critical role in defense against S. typhimurium infection and in the protection of intestinal integrity.
mechanism integrating BCR, TLR9, and cytokine signals provides a peripheral checkpoint for DNA-containing antigens that, if circumvented by survival and differentiative cues, yields B cells with the autoimmune-associated T-bet+ phenotype.
we demonstrated for the first time that the cross-talk of TLR2 and TLR9 triggered Th1 (show HAND1 Proteins) activation collaboratively
the cooperative role of TLR9 with TLR2 or TLR6 (show TLR6 Proteins) receptors in sensing Brucella, was determined.
accelerating effects of Tlr9 deficiency
TLR9 immunoreactivity is mainly detected in epithelial cells and antigen presenting cells, namely dendritic and macrophage-like cells, within the range of tissues examined. The pattern of TLR9 expression was similar in pigs of 3 weeks and 3 months of age.
These data demonstrated that TLR2, TLR3 (show TLR3 Proteins) and TLR9 contribute to NF-kappaB (show NFKB1 Proteins) activation in response to porcine epidemic diarrhea virus infection, but not RIG-I (show DDX58 Proteins).
expression of TLR3 (show TLR3 Proteins), TLR7 (show TLR7 Proteins) and TLR9 in alveolar macrophages infected with different genotype 1 PRRSV strains
we studied TLR9 expression in lung extracts from pigs, dogs, and cattle.
Moreover, the TLR9 transfectant demonstrated its usefulness for evaluation of immunostimulation by bacterial DNA through the detection of T(H)-1, T(H)-2 type cytokine induction via TLR9 signaling.
variants in the TLR1 (show TLR1 Proteins) gene are associated with susceptibility to bovine tuberculosis, whereas no significant association can be inferred from the polymorphisms in the TLR9 gene
mRNA abundances of TLR9, TLR2, and TLR4 (show TLR4 Proteins) together with those of beta-defensin 5 (BNBD5 (show DEFB105A Proteins)), an early bactericidal effector molecule of the innate system, in healthy and infected mammary glands
substantial conservation of TLR9 structure and TLR9 function in blood leukocytes
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.
Toll-like receptor 9 protein