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Human TLR9 Protein expressed in Wheat germ - ABIN1330558
Julian, Shao, Vangundy, Papenfuss, Crouser: Mitochondrial transcription factor A, an endogenous danger signal, promotes TNF? release via RAGE- and TLR9-responsive plasmacytoid dendritic cells. in PLoS ONE 2013
this study shows that that newborn naiive B cells express more TLR9 than adult B cells
TLR9 ligands may contribute to the immunopathogenesis of sarcoidosis via induction of CXCL10 (show CXCL10 Proteins) release in the alveolar macrophages.
The difference in TLR9 expression are involved in pathogenesis of the Systemic Lupus Erythematosus, hence it can be used as an indicator for Systemic Lupus Erythematosus diagnosis.
TLR9 regulates melanogenesis through NF-kappaB (show NFKB1 Proteins) activation, suggesting that TLR9 may play a role in microbial-induced melanogenesis.
mitochondrial DNA and TLR9 as the cargo and the receptor that triggers and mediates a lysosomal response to the arrival of autophagosomal cargo
TLR9 upregulation in cases with episomal HPV16 was again higher among those with non-methylated immunostimulatory CpG motifs. Comparison of cases with HPV-negative controls revealed that DNMT3A (show DNMT3A Proteins) was significantly downregulated only among integrated cases, DNMT3B (show DNMT3B Proteins) was significantly overexpressed among both categories of cases, although at variable levels, while DNMT1 (show DNMT1 Proteins) failed to show any deregulated expression among the cases
CPG-ODNs have inhibitory effects on S. aureus survival inside SAOS-2 osteoblast-like cell line. This effect was attributed to stimulation of TLR9 and subsequent induction of oxidative stress. Pretreatment of infected SAOS-2 cells with ROS (show ROS1 Proteins) inhibitors resulted in the abolishment of the CPG-ODNs killing effects.
Results suggest a potential role for the host genetic background in diabetes mellitus type 2 diabetic foot susceptibility and demonstrate that there is an association between TLR9-1237 T/C polymorphism and the risk of diabetic foot, but no association was found with TLR2
TLR9 induction can affect lung function by inactivating PTP1B (show PTPN1 Proteins) and upregulating expression of proinflammatory cytokines.
TLR9 may be promptly induced and recruit autophagy components from the endosome to autophagosome in response to stress.
The mRNA expression of TLR4 (show TLR4 Proteins) and NF-kappaB (show NFKB1 Proteins) is decreased in a neonatal murine model of necrotizing enterocolitis.
Although the TLR9 signaling pathway is not involved in the acute inflammatory response in infarct hearts, it ameliorates cardiac rupture possibly by promoting proliferation and differentiation of cardiac fibroblasts.
loss of Tlr9 selectively augments the intensity of IL-17 (show IL17A Proteins)-driven immune responses to H. pylori in a cag T4SS-dependent manner.
functional Tlr9 signaling in neutrophils, is an important mechanism in early stasis experimental venous thrombogenesis.
this paper shows that endosomal retention of TLR9 via the interaction of IRAP (show IL1RN Proteins) with the actin cytoskeleton is a mechanism that prevents hyper-activation of TLR9 in dendritic cells
data demonstrated for the first time that NK cells directly recognize Baculovirus via TLR9, which provides opportunities for the use of this technique as an effective tool for Baculovirus-based immunotherapies against malignancies.
3-Hydroxy-4,7-megastigmadien-9-one, isolated from Ulva pertusa, attenuates TLR9-mediated inflammatory response by down-regulating mitogen-activated protein kinase (show MAPK1 Proteins) and NF-kappaB (show NFKB1 Proteins) pathways.
Results demonstrate that nerve stimulation of TLR9 knock-out muscles produces weaker response than when the muscle is stimulated directly; TLR9 knock-out mice have functional and morphological alterations of the neuromuscular junction
Munc13-4 (show UNC13D Proteins) regulates endosome-initiated, TLR9-dependent signaling and TLR9-specific cellular functions in neutrophils.
TLR9 expression showed dynamic changes for a long period of time and microglias were the main brain cells to express TLR9 after cerebral ischemia and reperfusion.
TLR9 immunoreactivity is mainly detected in epithelial cells and antigen presenting cells, namely dendritic and macrophage-like cells, within the range of tissues examined. The pattern of TLR9 expression was similar in pigs of 3 weeks and 3 months of age.
These data demonstrated that TLR2, TLR3 (show TLR3 Proteins) and TLR9 contribute to NF-kappaB (show NFKB1 Proteins) activation in response to porcine epidemic diarrhea virus infection, but not RIG-I (show DDX58 Proteins).
expression of TLR3 (show TLR3 Proteins), TLR7 (show TLR7 Proteins) and TLR9 in alveolar macrophages infected with different genotype 1 PRRSV strains
we studied TLR9 expression in lung extracts from pigs, dogs, and cattle.
Moreover, the TLR9 transfectant demonstrated its usefulness for evaluation of immunostimulation by bacterial DNA through the detection of T(H)-1, T(H)-2 type cytokine induction via TLR9 signaling.
variants in the TLR1 (show TLR1 Proteins) gene are associated with susceptibility to bovine tuberculosis, whereas no significant association can be inferred from the polymorphisms in the TLR9 gene
mRNA abundances of TLR9, TLR2, and TLR4 together with those of beta-defensin 5 (BNBD5), an early bactericidal effector molecule of the innate system, in healthy and infected mammary glands
substantial conservation of TLR9 structure and TLR9 function in blood leukocytes
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.
Toll-like receptor 9 protein