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Human TLR9 Protein expressed in Wheat germ - ABIN1330558
Julian, Shao, Vangundy, Papenfuss, Crouser: Mitochondrial transcription factor A, an endogenous danger signal, promotes TNF? release via RAGE- and TLR9-responsive plasmacytoid dendritic cells. in PLoS ONE 2013
Multi-walled carbon nanotube induces injury or necrosis of lung epithelial cells and DNA damage via HMGB1 (show HMGB1 Proteins)/RAGE (show AGER Proteins)/TLR9 pathway.
Data suggest up-regulation of pro-inflammatory molecules TLR9, S100A8 (show S100A8 Proteins), and IL-8 (show IL8 Proteins) plus lower levels of CD11b (show ITGAM Proteins)+ CD33 (show CD33 Proteins)+ myeloid cells may be involved in impairment of wound healing in type 2 diabetes leading to chronic ulcers, such as diabetic foot ulcers.
9-mer (show MERTK Proteins) hairpin and G-quadruplex DNA fragments are nuclease (show DCLRE1C Proteins)-resistant DNA structures that can act as invasion-inducing TLR9 ligands.
In active rheumatoid arthritis patients, both TLR9 and TLR2 expression levels are increased in monocyte subsets.
This study shows that both TLR2 and TLR9 genes and single nucleotide polymorphism combinations do influence the clinical course of Chlamydia infections.
Excessive TLR9 signaling contributed to maternal-fetal tolerance disruption via an effect on Treg cell survival by activation of Caspase 8 (show CASP8 Proteins)/3
Study provided the foundation to discover the new molecular mechanism involving TLR9 in signaling networks of invasion and metastasis in prostate cancer.
These findings demonstrate differential reaction of cholinesterase-targeting miRNAs to distinct TLR9 challenges, indicating upstream miRNA co-regulation of the intestinal alternative NFkappaB pathway and cholinergic signaling.
Toll-like receptor 9 mediates OTSCC invasion and migration in vitro and is an independent prognostic factor of OTSCC.
no association between genetic polymorphism the hyper-IgE syndrome phenotype
TLR9 expression showed dynamic changes for a long period of time and microglias were the main brain cells to express TLR9 after cerebral ischemia and reperfusion.
activated ARF3 (show ARF3 Proteins) is associated with Unc93B1 and TLR9, suggesting that ARF3 (show ARF3 Proteins) conducts TLR9 trafficking by forming the TLR9-Unc93B1-ARF3 (show ARF3 Proteins) complex.
In mice, nonalcoholic steatohepatitis development in response to a high-fat diet required TLR9 on lysozyme (show LYZ Proteins)-expressing cells
TLR9 activation at high and low CpG ODN concentrations has roles in acute and chronic vascular injury in mice
The current study demonstrates for the first time an immunomodulatory role for TLR9 in acute kidney injury by enhancing the capacity of Tregs to migrate to damaged tissue in a model of common and relevant kidney disease.
recognition of beta-1,3 glucan by Dectin-1 (show CLEC7A Proteins) triggers TLR9 trafficking to beta-1,3 glucan-containing phagosomes, which may be critical in coordinating innate antifungal defense.
Sustained activation of Toll-like receptor 9 causes cardiac and systemic inflammation, and deterioration of SERCA2a (show ATP2A2 Proteins) depletion-mediated diastolic heart failure.
TLR9 signaling is involved in regulating adipose tissue inflammation and controlling obesity and the metabolic syndrome.
Genetic deletion of MyD88 (show MYD88 Proteins), TLR2 or TLR9 effectively controlled the signs of intestinal injury when compared with irinotecan-administered WT controls
TLR9 immunoreactivity is mainly detected in epithelial cells and antigen presenting cells, namely dendritic and macrophage-like cells, within the range of tissues examined. The pattern of TLR9 expression was similar in pigs of 3 weeks and 3 months of age.
These data demonstrated that TLR2, TLR3 (show TLR3 Proteins) and TLR9 contribute to NF-kappaB (show NFKB1 Proteins) activation in response to porcine epidemic diarrhea virus infection, but not RIG-I (show DDX58 Proteins).
expression of TLR3 (show TLR3 Proteins), TLR7 (show TLR7 Proteins) and TLR9 in alveolar macrophages infected with different genotype 1 PRRSV strains
we studied TLR9 expression in lung extracts from pigs, dogs, and cattle.
Moreover, the TLR9 transfectant demonstrated its usefulness for evaluation of immunostimulation by bacterial DNA through the detection of T(H)-1, T(H)-2 type cytokine induction via TLR9 signaling.
variants in the TLR1 (show TLR1 Proteins) gene are associated with susceptibility to bovine tuberculosis, whereas no significant association can be inferred from the polymorphisms in the TLR9 gene
mRNA abundances of TLR9, TLR2, and TLR4 together with those of beta-defensin 5 (BNBD5), an early bactericidal effector molecule of the innate system, in healthy and infected mammary glands
substantial conservation of TLR9 structure and TLR9 function in blood leukocytes
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.
Toll-like receptor 9 protein