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Early-onset sleep defects in mutated HTT (show HTT ELISA Kits) Drosophila models of Huntington's disease reflect alterations of PKA/CREB signaling.
changes suggest that dCREB2 functions in both the ellipsoid body and the mushroom body for long term memory formation, and that this activity contributes to the process of systems consolidation.
Our data suggest the model that Notch (show NOTCH1 ELISA Kits) and PKC (show PKC ELISA Kits) activities generate a cyclical accumulation of cytoplasmic hyper-PO4 CREB that is a precursor for generating the nuclear CREB isoforms.
Overexpression of a dCREB2 activator can enhance memory formation.
in light-light conditions, dCREB2 and NF-kappaB reporter flies exhibit suppression of rhythmic activity. Neuronal cycling of dCREB2 and NF-kappaB activity are modulated in period mutant flies, indicating these oscillations are controlled through the central clock
Drosophila CrebA directly binds the enhancers of secretory pathway genes and is both necessary and sufficient to activate expression of every secretory pathway component gene examined thus far.
direct and indirect interactions of the hsromega transcripts with a variety of regulatory proteins like hnRNPs, CBP (show EIF4E ELISA Kits), proteasome, Drosophila inhibitor of apoptosis protein 1 (show BIRC3 ELISA Kits) (DIAP1 (show DIAPH1 ELISA Kits))
This study demonstrates that CREB activity in either neuronal or peripheral tissues regulates energy balance in Drosophila.
Isoform, dCREB2-b, is a repressor of dCREB2-a. Here, we demonstrate that overexpression of dCREB2-b in virgin females enhances their sexual receptivity.
cAMP-response element-binding protein DNA binding in Drosophila is regulated by phosphorylation of conserved casein kinase sites
Transcriptional activator. Binds to fat body-specific enhancers of alcohol dehydrogenase (ADH) and yolk protein genes. BBF-2 may play a role in fat body gene expression. It binds the consensus sequence 5'-TC-3'.
, cAMP response element-binding protein
, cAMP-regulated enhancer-binding protein
, cAMP-response element binding protein
, cAMP-response element-binding protein
, cyclic AMP response element binding protein
, Box B-binding factor 2
, cAMP response element binding protein
, cAMP response element binding protein A