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Dynamin 2 Proteins (DNM2)
On www.antibodies-online.com are 7 Dynamin 2 (DNM2) Proteins from 4 different suppliers available. Additionally we are shipping Dynamin 2 Antibodies (45) and Dynamin 2 Kits (30) and many more products for this protein. A total of 86 Dynamin 2 products are currently listed.
Synonyms:
CMT2M, CMTDI1, CMTDIB, DI-CMTB, dnm2, DYIIAAB, Dyn2, dynamin-2, DYNII, LCCS5, Udnm, zgc:114072
list all proteins Gene Name GeneID UniProt
DNM2 1785 P50570
DNM2 13430 P39054
Rat DNM2 DNM2 25751 P39052

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Dynamin 2 Proteins (DNM2) by Origin

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More Proteins for Dynamin 2 Interaction Partners

Human Dynamin 2 (DNM2) interaction partners

  1. Study showed that dynamin 2 and cortactin participate in the formation of F-actin bundles, which stabilize filopodia in migrating cancer cells.

  2. Data demonstrate that dynamin II is required for the E2:ERalpha (show ESR1 Proteins) signaling of physiological functions and uncovers a role for autophagy in the control of ERalpha (show ESR1 Proteins) turnover.

  3. This study reported the clinical characteristics, molecular diagnosis strategy, and DNM2 gene mutations of four Chinese Han patients with centronuclear myopathy.

  4. uncover a link between the dynamin 2 function and JNK (show MAPK8 Proteins) signaling which leads to AP-1 (show FOSB Proteins) induction

  5. results provide evidence for a novel Arf6 (show ARF6 Proteins) activation mechanism by Dyn2 through EFA6B and EFA6D (show PSD3 Proteins) in CME in a manner dependent upon the GTPase (show RACGAP1 Proteins) activity of Dyn2

  6. We conclude that DNM2 is a novel negative regulator of NO production in mouse collecting ducts.

  7. In marked contrast to invadopodia, this degradation does not require the action of Src kinase (show CSK Proteins), Cdc42 (show CDC42 Proteins) or Dyn2. Rather, inhibition of Dyn2 causes a marked upregulation of stromal matrix degradation

  8. exome sequencing family study reveals that autosomal dominant spastic paraplegia linked to a GTPase (show RACGAP1 Proteins)-effector domain mutation of dynamin 2

  9. This study demonistrated that DNM2 mutation releated to Centronuclear myopathy.

  10. Dynamin 2 deletion in beta cells caused glucose intolerance and reduced the 2d phase of glucose-stimulated insulin secretion. Dynamin 2 regulates insulin secretory capacity and dynamics in vivo via a mechanism depending on CME and F-actin remodeling.

Mouse (Murine) Dynamin 2 (DNM2) interaction partners

  1. DNM2 mutations cooperate with Lmo2 (show LMO2 Proteins) T-cell oncogenes by enhancing IL-7 (show IL7 Proteins) signalling.

  2. Genetic disruption of Dyn2 GTPase (show RACGAP1 Proteins) activity selectively in hepatic stellate cells enhances fibrogenesis.

  3. Oxidative stress-induced (show SQSTM1 Proteins) apoptosis and reactive oxygen species production are attenuated by not only Drp1 (show CRMP1 Proteins) inhibition but also Dynamin 2 inhibition, implicating Dynamin 2 as a mediator of oxidative stress in cardiomyocytes.

  4. Results show that centronuclear myopathy associated Dyn2 mutants are gain-of-function mutations, and their primary effect in muscle is T-tubule disorganization, which explains the susceptibility of muscle to Dyn2 hyperactivity.

  5. Dynamin 2 might participate in the early embryonic development through an actin-based cytokinesis

  6. Dynamin 2 has a role in endocytosis and in sustaining T-cell receptor signaling and driving metabolic reprogramming in T lymphocytes

  7. DNM2-dependent endocytosis in megakaryocytes regulates megakaryopoiesis, thrombopoiesis, and bone marrow homeostasis.

  8. Thus dynamin (show DNM1 Proteins) that was recently found to control late stages of myoblast fusion also controls late stages of macrophage fusion, revealing an intriguing conserved mechanistic motif shared by diverse cell-cell fusion processes.

  9. Using an inducible knockout mouse model to generate dynamin 1 (show DNM1 Proteins)- and 2-deficient primary osteoclast precursors and myoblasts, it was shown that fusion of both cell types requires dynamin (show DNM1 Proteins).

  10. FGF21 (show FGF21 Proteins) has a role in promoting endothelial cell angiogenesis through a dynamin-2 and Rab5 (show RAB5A Proteins) dependent pathway

Cow (Bovine) Dynamin 2 (DNM2) interaction partners

  1. Dynamin-2 directs actin polymerization at the exocytosis site where both, in concert, adjust the hormone quantal release.

  2. role of the proline-rich domain of dynamin-2 in in vitro potentiation of endothelial nitric-oxide synthase (show NOS3 Proteins) activity.

  3. Knocking down dynamin-2 by small interfering RNA reduced both leukotoxin internalization and cytotoxicity.

  4. LKT-mediated cell death involve dynamin-2 and cyclophilin D (show PPIF Proteins)

Zebrafish Dynamin 2 (DNM2) interaction partners

  1. DNM2-S619L causes disease, in part, by interfering with membrane tubulation

  2. Our findings suggest that dnm2 and dnm2-like are orthologs to human DNM2, and that they are required for normal zebrafish development.

Pig (Porcine) Dynamin 2 (DNM2) interaction partners

  1. Upregulation of miR (show MYLIP Proteins)-124 expression corresponded to decreased expression of its target, DNM2, in the Japanese encephalitis virus -infected PK15 cells.

  2. Dynamin 2 possibly regulates porcine oocyte maturation through its effects on actin-mediated spindle positioning and cytokinesis, and that this may depend on regulating ARP2 (show ACTR2 Proteins) localization.

Dynamin 2 (DNM2) Protein Profile

Protein Summary

Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined.

Alternative names and synonyms associated with Dynamin 2 (DNM2)

  • dynamin 2 (DNM2)
  • dynamin 2 (dnm2)
  • dynamin 2 (Dnm2)
  • dynamin 2a (dnm2a)
  • dynamin-2-like (LOC100622538)
  • dynamin-2-like (LOC430067)
  • CMT2M protein
  • CMTDI1 protein
  • CMTDIB protein
  • DI-CMTB protein
  • dnm2 protein
  • DYIIAAB protein
  • Dyn2 protein
  • dynamin-2 protein
  • DYNII protein
  • LCCS5 protein
  • Udnm protein
  • zgc:114072 protein

Protein level used designations for Dynamin 2 Proteins (DNM2)

dynamin-2 , dynamin 2 , dynamin-2-like , dynamin II

GENE ID SPECIES
455718 Pan troglodytes
496487 Xenopus (Silurana) tropicalis
713558 Macaca mulatta
100011387 Monodelphis domestica
100101298 Xenopus laevis
100412229 Callithrix jacchus
100442734 Pongo abelii
1785 Homo sapiens
13430 Mus musculus
25751 Rattus norvegicus
511691 Bos taurus
100717689 Cavia porcellus
484949 Canis lupus familiaris
101115027 Ovis aries
559334 Danio rerio
100622538 Sus scrofa
430067 Gallus gallus
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