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results suggest a new mechanism in which Rab5 (show RAB5A ELISA Kits) induces a change in flexibility of EEA1, generating an entropic collapse force that pulls the captured vesicle towards the target membrane to initiate docking and membrane fusion
EEA1 mobility on endosomes is decreased upon stimulation of EGF receptor (show EGFR ELISA Kits) endocytosis in HeLa cells
Under the regulation of Rab5 (show RAB5A ELISA Kits), the fused vesicles are targeted to early endosomes and thus deliver the internalized TbetaRI (show TGFBR1 ELISA Kits) to the caveolin-1 (show CAV1 ELISA Kits) and EEA1 double-positive early endosomes (caveolin-1 (show CAV1 ELISA Kits)-positive early endosomes).
In serum-deprivated HeLa cells with low endocytic activity there two types of EEA1-vesicles: the first one carries the both EEA1 and Rab5 (show RAB5A ELISA Kits) at high levels; the second consists of weakly decorated EEA1-vesicles that can be both Rab5 (show RAB5A ELISA Kits)-positive and -negative.
Data indicate that early endosome antigen 1 (EEA1) is important for the small GTPase (show RACGAP1 ELISA Kits) Rab31 (show RAB31 ELISA Kits)-mediated enhancement of ligand-bound EGF receptor (EGFR (show EGFR ELISA Kits)) endocytic trafficking.
nuclear uptake of Abeta (show APP ELISA Kits) involves the dynamin (show DNM1 ELISA Kits)-dependent EEA1 and TGF-beta (show TGFB1 ELISA Kits)/Smad (show SMAD1 ELISA Kits) signaling pathways.
We therefore propose that the N1072K variant of the EEA1 gene is a candidate mutation for susceptibility to diabetes in the Japanese population.
EEA1 interacts with Phafin2 and colocolizes with Phafin2 in endosome membrane.
NMR analyses of the interaction between the FYVE domain of early endosome antigen 1 (EEA1) and phosphoinositide embedded in a lipid bilayer.
p97 (show EIF4G2 ELISA Kits) inhibition causes increased EEA1 self-association at the endosome membrane.
In the present study, decreased expression of EEA1 as well as the rearrangement of the actin was observed when Paracoccidioides brasiliensis was internalized in macrophages.
Tec (show NR4A3 ELISA Kits) vesicles have a membrane proximal location and overlap with the tyrosine kinase (show TYRO3 ELISA Kits) Lck (show LCK ELISA Kits), the Tec (show NR4A3 ELISA Kits) substrate PLC-gamma1 (show PLCG1 ELISA Kits), and the early endosomal antigen 1 marker EEA1
phosphomimetic mutation of Thr (show TRH ELISA Kits)-1392 in EEA1 can bypass the requirement for p38alpha (show MAPK14 ELISA Kits) in mu opioid receptor (show OPRM1 ELISA Kits) endocytosis
F. tularensis-containing endosomes associated with early endosome antigen 1 (EEA1) followed by lysosome-associated membrane protein 1 (LAMP-1 (show LAMP1 ELISA Kits)), with peak coassociation frequencies occurring at 30 and 120 min postinoculation, respectively.
Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.
early endosome antigen 1, 162kD
, novel protein similar to H.sapiens EEA1, early endosome antigen 1 (EEA1)
, early endosome-associated protein
, endosome-associated protein p162
, zinc finger FYVE domain-containing protein 2