Browse our anti-NFKB2 (NFKB2) Antibodies

Full name:
anti-Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (p49/p100) Antibodies (NFKB2)
On are 123 Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (p49/p100) (NFKB2) Antibodies from 16 different suppliers available. Additionally we are shipping NFKB2 Kits (20) and NFKB2 Proteins (10) and many more products for this protein. A total of 157 NFKB2 products are currently listed.
lyt, NF-kappaB2, p49, p49/p100, p50B, p52
list all antibodies Gene Name GeneID UniProt
NFKB2 18034 Q9WTK5

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anti-Mouse (Murine) NFKB2 Antibodies:

anti-Human NFKB2 Antibodies:

anti-Rat (Rattus) NFKB2 Antibodies:

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Top referenced anti-NFKB2 Antibodies

  1. Human Polyclonal NFKB2 Primary Antibody for IF, IHC (p) - ABIN197118 : Qu, Qing, Rabson, Xiao: Tax deregulation of NF-kappaB2 p100 processing involves both beta-TrCP-dependent and -independent mechanisms. in The Journal of biological chemistry 2004 (PubMed)
    Show all 5 references for 197118

  2. Cow (Bovine) Polyclonal NFKB2 Primary Antibody for IHC, WB - ABIN2779436 : Xiao, Fong, Sun: Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation. in The Journal of biological chemistry 2004 (PubMed)
    Show all 3 references for 2779436

  3. Human Polyclonal NFKB2 Primary Antibody for IF, IHC (p) - ABIN197572 : Shin, Minter, Cho, Gottipati, Fauq, Golde, Sonenshein, Osborne: Notch1 augments NF-kappaB activity by facilitating its nuclear retention. in The EMBO journal 2006 (PubMed)
    Show all 3 references for 197572

  4. Cow (Bovine) Polyclonal NFKB2 Primary Antibody for IHC, WB - ABIN2777546 : Suen, Uddin, Prow, Bowen, Hall, Bielefeldt-Ohmann: Tissue-specific transcription profile of cytokine and chemokine genes associated with flavivirus control and non-lethal neuropathogenesis in rabbits. in Virology 2016 (PubMed)
    Show all 2 references for 2777546

More Antibodies against NFKB2 Interaction Partners

Mouse (Murine) Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (p49/p100) (NFKB2) interaction partners

  1. MKK4 (show MAP2K4 Antibodies) activates non-canonical NFkappaB signaling by promoting NFkappaB2-p100 (show PATL2 Antibodies) processing.

  2. the aberrant proliferative capacity of Brca1 (show BRCA1 Antibodies)(-/-) luminal progenitor cells is linked to the replication-associated DNA damage response, where proliferation of mammary progenitors is perpetuated by damage-induced, autologous NF-kappaB (show NFKB1 Antibodies) signaling.

  3. RelB (show RELB Antibodies) is processed by CO2 in a manner dependent on a key C-terminal domain located in its transactivation domain. Loss of the RelB (show RELB Antibodies) transactivation domain alters NF-kappaB (show NFKB1 Antibodies)-dependent transcriptional activity, and loss of p100 (show PATL2 Antibodies) alters sensitivity of RelB (show RELB Antibodies) to CO2

  4. the individual functions of the NF-kappaB (show NFKB1 Antibodies) family members NF-kappaB1 (show NFKB1 Antibodies), NF-kappaB2 and c-REL (show NFkBP65 Antibodies) in the various autoimmune pathologies of Fas(lpr/lpr (show FAS Antibodies)) mutant mice, were investigated.

  5. we identify in this study a critical role for the combined activity of the RELB (show RELB Antibodies) and NF-kappaB2 subunits in B cell homeostasis that cannot be compensated for by the canonical NF-kappaB (show NFKB1 Antibodies) pathway under physiological conditions.

  6. Mechanistically the LncRNA-HIT siRNA treatments impacted pro-chondrogenic gene expression by reducing H3K27ac or p100 (show PATL2 Antibodies) activity, confirming that LncRNA-HIT is essential for chondrogenic differentiation in the limb mesenchyme

  7. Nfkb2 connected lymphotoxin (show LTB Antibodies) signal within the intestinal niche in reinforcing epithelial innate inflammatory RelA (show NFkBP65 Antibodies)/NF-kappaB (show NFKB1 Antibodies) response to Citrobacter rodentium infection, while Nfkb2(-/-) mice succumbed to gut (show GUSB Antibodies) infections owing to stromal defects.

  8. Data indicate a coupled increase in the expression of renal, relA (show NFkBP65 Antibodies), NF-kB2, and p53 (show TP53 Antibodies) genes and proteins during folic acid induced acute kidney injury (AKI).

  9. Loss of c-REL (show NFkBP65 Antibodies) but not NF-kappaB2 prevents autoimmune disease driven by FasL (show FASL Antibodies) mutation.

  10. NF-kappaB2/p52 is necessary for the development of colitis, whilst c-Rel (show NFkBP65 Antibodies)-mediated signalling regulates colonic epithelial cell turnover following DNA damage.

NFKB2 Antigen Profile

Antigen Summary

NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF- kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14- activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form\; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65 (By similarity).

Alternative names and synonyms associated with NFKB2

  • nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 (Nfkb2) antibody
  • lyt antibody
  • NF-kappaB2 antibody
  • p49 antibody
  • p49/p100 antibody
  • p50B antibody
  • p52 antibody

Protein level used designations for NFKB2

DNA-binding factor KBF2 , NF kappaB2 , nuclear factor NF-kappa-B p100 subunit , nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100

18034 Mus musculus
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