Browse our ATOX1 Proteins (ATOX1)

Full name:
ATX1 Antioxidant Protein 1 Homolog (Yeast) Proteins (ATOX1)
On are 17 ATX1 Antioxidant Protein 1 Homolog (Yeast) (ATOX1) Proteins from 7 different suppliers available. Additionally we are shipping ATOX1 Antibodies (29) and many more products for this protein. A total of 47 ATOX1 products are currently listed.
AI256639, ATOX1, Atx1, CG12562, CG32446, DDBDRAFT_0185901, DDBDRAFT_0266724, DDB_0185901, DDB_0266724, DmAtox1, Dmel\\CG32446, HAH1, SAH
list all proteins Gene Name GeneID UniProt
ATOX1 475 O00244
ATOX1 84355 Q9WUC4
ATOX1 11927 O08997

Show all synonyms

ATOX1 Proteins (ATOX1) by Origin

Select your origin of interest

Top referenced ATOX1 Proteins

  1. Human ATOX1 Protein expressed in Escherichia coli (E. coli) - ABIN666917 : Hamza, Schaefer, Klomp, Gitlin: Interaction of the copper chaperone HAH1 with the Wilson disease protein is essential for copper homeostasis. in Proceedings of the National Academy of Sciences of the United States of America 1999 (PubMed)
    Show all 2 references for 666917

More Proteins for ATOX1 Interaction Partners

Fruit Fly (Drosophila melanogaster) ATX1 Antioxidant Protein 1 Homolog (Yeast) (ATOX1) interaction partners

  1. results clearly reveal a distorted copper homeostasis in Atox1-deficient Drosophila

Human ATX1 Antioxidant Protein 1 Homolog (Yeast) (ATOX1) interaction partners

  1. Highlighted in this review are unique redox properties of Atox1 and other copper chaperones. Also, summarized are the redox nodes in the cytosol which potentially play dominant roles in the redox regulation of copper chaperones

  2. The structural flexibility of the human copper chaperone Atox1 has been reported based on insights from combined pulsed EPR (show EREG Proteins) studies and computations.

  3. Cu chaperone Atox1 has a role in breast cancer cell migration

  4. Multiple genetic models identified genetic associations with systolic blood pressure and ATOX1.

  5. In addition to Atox1, the human cytoplasm also contains Cu chaperones for loading of superoxide dismutase 1 (show SOD1 Proteins) (i.e. CCS (show CCS Proteins)) and cytochrome c (show CYCS Proteins) oxidase in mitochondria (i.e. Cox17 (show COX17 Proteins)). [review]

  6. results suggest the possibility of a therapy with copper-chelating or ionophore drugs in subtypes of tumors showing specific alterations in ATOX1 expression

  7. C-Terminus of Human Copper Importer Ctr1 (show SLC31A1 Proteins) Acts as a Binding Site and Transfers Copper to Atox1

  8. Cu chaperone function of Atox1 mediated through Cu transporter ATP7A (show ATP7A Proteins) is required for VEGF (show VEGFA Proteins)-induced angiogenesis via activation of Cu enzyme lysyl oxidase (show LOX Proteins).

  9. Upon neuronal differentiation, transitions in redox states upregulates expression of ATOX1 and its partner ATP7A (show ATP7A Proteins), producing higher flux of copper through the secretory pathway.

  10. To identify new interactions partners of Atox1, a yeast two-hybrid screen with a large human placenta library of cDNA fragments using Atox1 as bait, was performed.

Mouse (Murine) ATX1 Antioxidant Protein 1 Homolog (Yeast) (ATOX1) interaction partners

  1. ATOX1 appeared ubiquitously expressed throughout the cells until compaction; in subsequent embryo stages, ATOX1 relocalized to cytoplasmic perinuclear domains in the inner cell mass. Silencing of Oct4 (show POU5F1 Proteins) did not affect Atox1 expression, but silencing of Atox1 at the 2-cell stage strongly diminished Oct4 (show POU5F1 Proteins) expression in 16-cell embryos.

  2. Cu chaperone function of Atox1 mediated through Cu transporter ATP7A (show ATP7A Proteins) is required for VEGF (show VEGFA Proteins)-induced angiogenesis via activation of Cu enzyme lysyl oxidase (show LOX Proteins).

  3. Atox1 is involved in neointimal formation after vascular injury through promoting vascular smooth muscle cell migration and inflammatory cell recruitment in injured vessels

  4. Atox1 functions to prevent Ang II (show AGT Proteins)-induced endothelial dysfunction and hypercontraction in resistant vessels, as well as hypertension.

  5. the importance of Atox1, not only as a metallochaperone for delivering Cu to cuproenzymes, but also as a key player in maintaining the proper distribution and organization of Cu at the cellular level

  6. ATOX1 is a cytoplasmic copper chaperone that interacts with the copper-binding domain of the membrane copper transporters ATP7A (show ATP7A Proteins) and ATP7B (show ATP7B Proteins)

  7. Atox1 has a role in establishing the threshold for copper-dependent movement of the copper-transporting ATPases within the secretory compartment

  8. Atox1 functions not only as a copper chaperone for SOD3 (show SOD3 Proteins) but also as a positive regulator for SOD3 (show SOD3 Proteins) transcription and may have an important role in modulating oxidative stress in the cardiovascular system.

  9. Atox1 functions as a novel transcription factor that, when activated by copper, undergoes nuclear translocation, DNA binding, and transactivation, thereby contributing to cell proliferation.

  10. both the copper chaperone and the transcription factor functions are required for the activity of antioxidant enzyme, superoxide dismutase (SOD3 (show SOD3 Proteins))

ATOX1 Protein Profile

Protein Summary

This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome.

Alternative names and synonyms associated with ATOX1

  • ATX1 antioxidant protein 1 homolog (yeast) (ATOX1)
  • CG32446 gene product from transcript CG32446-RA (Atox1)
  • ATX1 antioxidant protein 1 homolog (atox1)
  • copper transport protein (atox1)
  • Copper transport protein ATOX1 (atox1)
  • ATX1 antioxidant protein 1 homolog (LOC100335457)
  • antioxidant 1 copper chaperone (ATOX1)
  • antioxidant 1 copper chaperone (Atox1)
  • ATX1 (antioxidant protein 1) homolog 1 (yeast) (Atox1)
  • AI256639 protein
  • ATOX1 protein
  • Atx1 protein
  • CG12562 protein
  • CG32446 protein
  • DDBDRAFT_0185901 protein
  • DDBDRAFT_0266724 protein
  • DDB_0185901 protein
  • DDB_0266724 protein
  • DmAtox1 protein
  • Dmel\\CG32446 protein
  • HAH1 protein
  • SAH protein

Protein level used designations for ATOX1

ATX1 antioxidant protein 1 homolog (yeast) , copper transport protein ATOX1 , antioxidant protein 1 homolog , Atox1-PA , Atox1-PB , CG32446-PA , CG32446-PB , ATX1 antioxidant protein 1 homolog , Copper transport protein ATOX1 , metal transport protein ATX1 , ATX1 (antioxidant protein 1) homolog 1 , ATX1 homolog protein Rah1 , copper chaperone , copper chaperone SAH

743743 Pan troglodytes
770231 Gallus gallus
100312962 Sus scrofa
326216 Drosophila melanogaster
734100 Xenopus (Silurana) tropicalis
8624483 Dictyostelium discoideum AX4
100301872 Oncorhynchus mykiss
100335457 Bos taurus
475 Homo sapiens
84355 Rattus norvegicus
11927 Mus musculus
613998 Bos taurus
403713 Canis lupus familiaris
443451 Ovis aries
Selected quality suppliers for ATOX1 Proteins (ATOX1)
Did you look for something else?