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ferritin H not only responds to changes in tissue iron (its classic role), but can actively regulate overall tissue iron balance
mitochondrial ferritin has a role in tumor growth inhibition by cytosolic iron deprivation
PIAS3 (show PIAS3 ELISA Kits) is a new regulator of ATF1 (show AFT1 ELISA Kits) that regulates the ARE-mediated transcription of the ferritin H gene
ionomycin-mediated induction of ferritin H may occur in an NFAT (show NFATC1 ELISA Kits)-independent manner but through post-transcriptional stabilization of the ferritin H mRNA.
ferritin H transcription is activated by rotenone via an oxidative stress-mediated pathway leading to antioxidant-responsive element activation
Our results provide evidence that the iron storage function of ferritin (show FTL ELISA Kits) plays a major role in preventing iron-mediated cell and tissue damage.
experimental overexpression of FTMT may modify mitochondrial iron availability and lead to ineffective erythropoiesis
FtMt mutation may determine a condition similar to haploinsufficiency resulting in a reduced protection from iron-dependent oxidative stress in mitochondria
Stat5 (show STAT5A ELISA Kits)-dependent transcriptional regulation is displaced by strong cytosolic iron starvation status induced by mitochondrial ferritin.
higher protein levels in prostate cancer cells expressing a dominant negative mutant of p66Shc (show SHC1 ELISA Kits)
MtF is involved in the pathology of Alzheimer's disease and may play a neuroprotective role against oxidative stress
MtF expression is downregulated during ATRA-induced K562 cell differentiation, with concomitant downregulation of TfR1 (show TFRC ELISA Kits) and upregulation of Fn.
The analysis suggests that sequence variations in the coding region of FtMt are not involved in the development of myelodysplastic syndromes and Parkinson's disease.
Primary spontaneous pneumothorax in smokers is associated with lung macrophage oxidative stress. The response to this condition involves HIF-1alpha (show HIF1A ELISA Kits)-mediated induction of HO-1 (show HMOX1 ELISA Kits), BVR (show BLVRA ELISA Kits) and H-ferritin.
Human mitochondrial ferritin expressed in HeLa cells incorporates iron and affects cellular iron metabolism
RT-PCR studies showed MtF mRNA in circulating reticulocytes of 2 X-linked sideroblastic anemia patients but not controls. Most of the iron in perinuclear mitochondria of ring sideroblasts is in the form of MtF, a specific marker of sideroblastic anemia.
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity).
, ferritin H
, ferritin heavy chain 3
, ferritin, mitochondrial
, ferritin H subunit
, ferritin heavy chain, oocyte isoform