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Human Monoclonal HMOX1 Primary Antibody for IF, IP - ABIN968130
Foresti, Clark, Green, Motterlini: Thiol compounds interact with nitric oxide in regulating heme oxygenase-1 induction in endothelial cells. Involvement of superoxide and peroxynitrite anions. in The Journal of biological chemistry 1997
Show all 4 Pubmed References
Hamster Polyclonal HMOX1 Primary Antibody for IP, IHC - ABIN223113
Song, Shih, Chan, Zhang: Suppression of annexin A11 in ovarian cancer: implications in chemoresistance. in Neoplasia (New York, N.Y.) 2009
Show all 4 Pubmed References
Cow (Bovine) Monoclonal HMOX1 Primary Antibody for ICC, IF - ABIN361697
Brydun, Watari, Yamamoto, Okuhara, Teragawa, Kono, Chayama, Oshima, Ozono: Reduced expression of heme oxygenase-1 in patients with coronary atherosclerosis. in Hypertension research : official journal of the Japanese Society of Hypertension 2007
Show all 9 Pubmed References
Human Monoclonal HMOX1 Primary Antibody for IF, IP - ABIN968129
Ishikawa, Navab, Leitinger, Fogelman, Lusis: Induction of heme oxygenase-1 inhibits the monocyte transmigration induced by mildly oxidized LDL. in The Journal of clinical investigation 1997
Show all 4 Pubmed References
Human Monoclonal HMOX1 Primary Antibody for BP, ELISA - ABIN257888
Machado, Malheiros, Adamy, Santos, Silva Filho, Nahas, Lemos: Protective response in renal transplantation: no clinical or molecular differences between open and laparoscopic donor nephrectomy. in Clinics (São Paulo, Brazil) 2013
Show all 3 Pubmed References
Cow (Bovine) Polyclonal HMOX1 Primary Antibody for WB - ABIN2782158
Hausmann, Paul, Kellermeier, Frey, Schölmerich, Falk, Menzel, Fried, Herfarth, Rogler: (GT)N dinucleotide repeat polymorphism of haem oxygenase-1 promotor region is not associated with inflammatory bowel disease risk or disease course. in Clinical and experimental immunology 2008
Show all 2 Pubmed References
Mouse (Murine) Polyclonal HMOX1 Primary Antibody for WB - ABIN2482079
Bae, Kim, Jang, Lee: Protective effects of heme oxygenase-1 against MPP(+)-induced cytotoxicity in PC-12 cells. in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2010
Show all 7 Pubmed References
Human Polyclonal HMOX1 Primary Antibody for ELISA, WB - ABIN561294
Hong, Kim, Kim, Lee, Shin, Son, Han, Sung, Kwon: Apoptosis induction of 2'-hydroxycinnamaldehyde as a proteasome inhibitor is associated with ER stress and mitochondrial perturbation in cancer cells. in Biochemical pharmacology 2007
Hamster Polyclonal HMOX1 Primary Antibody for IHC, IP - ABIN4319615
Heeba, Hamza, Hassanin: Induction of heme oxygenase-1 with hemin alleviates cisplatin-induced reproductive toxicity in male rats and enhances its cytotoxicity in prostate cancer cell line. in Toxicology letters 2016
Human Polyclonal HMOX1 Primary Antibody for ICC, IF - ABIN441348
Bakkar, Kousari, Kovalik, Li, Bowser: RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1. in Molecular and cellular biology 2015
study evaluated the time-course of HO-1 and catalase (show CAT Antibodies) gene expressions in nodules and roots of soybean plants subjected to cadmium treatment
Data suggest expression of hsp32 is up-regulated in kidney epithelial cells upon in vitro exposure to heavy metal water pollutants (Cd, As) or proteasomal inhibitors (MG132, withaferin A, celastrol); heat shock may be synergistic factor.
this study provides a better understanding of the role of the HO-1/Carbon monoxide system in controlling heart function in lower vertebrates.
The induced expression of HO-1 by fenofibrate appeared to be essential for mediating the protective effects of fenofibrate, as the inhibition of HO-1 activity significantly diminished the protective effects of fenofibrate against the GM-mediated death of sensory hair cells in cochlea
Suggest that Gata-1 (show GATA1 Antibodies) and Nrf2a (show NFE2L2 Antibodies) play differential roles in regulating the heme degradation enzymes hmox1a/bvra (show BLVRA Antibodies)/bvrb (show BLVRB Antibodies) during an early developmental period of heightened cellular stress.
Bach1 (show BACH1 Antibodies) regulates the liver specificity and transience of the Nrf2a (show NFE2L2 Antibodies)-dependent induction of hmox1a and that heme mediates this regulation through Bach1 (show BACH1 Antibodies) inhibition based on its level in each tissue.
Data indicate that Heme oxygenase 1 (HY1) functioned negatively and acted upstream of ABSCISIC ACID-INSENSITIVE4 (ABI4) in drought signaling.
HY1 confers cadmium tolerance by decreasing nitric oxide production and improving iron homeostasis.
Data indicate that AtHO1 (HY1; heme oxygenase-1)-overexpressing plants generated more NO, whereas knock-down of AtHO1 expression reduced the level of nitric oxide (NO) in plants.
HY1 mutant exhibited progressive salt hypersensitivity.
Disrupting the binding of the AtHBP5 to haem oxygenase 1 (HY1) leads to oxidative stress.
Mutation of HY1 causes UV-C hypersensitivity by impairing carotenoid and flavonoid biosynthesis and the down-regulation of antioxidant defence.
HY1 and HY5 additively regulate the expression of light regulated genes and accumulation of chlorophyll and anthocyanin during early seedling development.
HY1 (Heme oxygenase 1) plays an important role in salt acclimation.
all members of the HO1 subfamily (HY1, HO3 and HO4) are active monomeric HOs and can convert haem to BV IXalpha using spinach Fd (ferredoxin) as an electron donor
HO2 (show HMOX2 Antibodies) has an activity high enough to substitute for HO1 under aerobic conditions.
Downregulation of inducible NO synthetase (iNOS (show NOS2 Antibodies)) resulted in downregulation of heme oxygenase 1 (HO-1), and, conversely, upregulation of iNOS (show NOS2 Antibodies) enhanced HO-1 activity.
The cessation of HO-1 induction occurred at the transcriptional and translational levels, and was mediated by the activation of the heme-binding transcriptional repressor Bach1 (show BACH1 Antibodies) and translational factor HRI (show EIF2AK1 Antibodies).
The induction of HO-1 expression by proteasome inhibition was reduced in PINK1 (show PINK1 Antibodies) G309D mutant cells.
there was little difference in HMOX1 genotypes distribution in patients with chronic obstructive pulmonary disease with different severity.
investigation of the possible role of HMOX1 in adipose tissue, adipogenesis and iron metabolism; adipose tissue HMOX1 was increased in obese participants and positively associated with obesity-related metabolic disturbances, and markers of iron accumulation, inflammation and oxidative stress
the HO-1 interactome in prostate cancer, is identified.
induction of HO1 by M. tuberculosis infection may be a mycobacterial virulence mechanism to enhance inflammation and bacterial growth
Data (including data from studies using cells from knockout mice) confirm that the NRF2 (show GABPA Antibodies)/HMOX1 axis is a critical pathway in the hyperglycemic-mediated dysregulation and inflammatory features of chondrocytes in type 2 diabetes-associated osteoarthritis. (NRF2 (show GABPA Antibodies) = nuclear factor [erythroid-derived 2]-like 2 protein; HMOX1 = heme oxygenase [decycling] 1)
To promote intracellular iron flux, an iron chaperone appears to be essential for receiving iron from heme catabolism. Data suggest that PCBP2 (show PCBP2 Antibodies) competes with CPR (show POR Antibodies) for binding HO1; PCBP2 (show PCBP2 Antibodies) K homology 3 domain is important for HO1/PCBP2 (show PCBP2 Antibodies) interaction; heme prompts HO1/CPR (show POR Antibodies) multimer and decreases HO1/PCBP2 (show PCBP2 Antibodies) multimer. [PCBP2 (show PCBP2 Antibodies) = poly(rC) binding protein 2 (show PCBP2 Antibodies); CPR (show POR Antibodies) = cytochrome P450 reductase (show POR Antibodies); HO1 = heme oxidase 1]
Mechanistically, HO-1 induction by all CRLPs requires NADPH oxidase 4 (show NOX4 Antibodies), with PUFA-containing particles additionally dependent upon mitochondrial reactive oxygen species.These studies define new molecular pathways coupling endothelial cell activation by model CMRs with adaptive regulation of Nrf2 (show GABPA Antibodies)-dependent HO-1 expression
findings collectively suggest that miR (show MYLIP Antibodies)-506 acts as a tumor suppressor via regulation of ROCK1 (show ROCK1 Antibodies) expression and may thus be a promising therapeutic target for HCC (show FAM126A Antibodies)
Exogenous administration of CO exacerbated allergic symptoms, resulting in higher levels of both CO and heme oxygenase-1 expression, and a further reduction in H2S levels and CSE expression.
Down-regulation of HO-1 is associated with pulmonary arterial hypertension and right ventricular failure.
The study revealed the involvement of HO-1 in classical swine fever virus proliferation.
The protective properties of flavonoids, such as EGCG, against endothelial inflammation may be regulated in part though induction of HO-1 and subsequent activator protein-1 signaling.
Glutamate (show GRIN2C Antibodies) regulates Ca2 (show CA2 Antibodies)+ signals in smooth muscle cells of newborn piglet brain slice arterioles through astrocyte- and heme oxygenase-dependent mechanisms.
obalt protoporphyrin prevents postictal cerebral vascular dysfunction by upregulating HO-1.
Data demonstrate that lipopolysaccharides evoke a heat shock response, with an increase heat shock proteins 70 and Hsp32) and of VEGF (show VEGFA Antibodies), a specific endothelial cell growth factor (show FGF1 Antibodies).
Interaction of soluble factors in plasma possibly generated during PICSO are not responsible for upregulation of HO-1 and VEGF mRNA.
the data were consistent with HO-1 acting as an anti-viral factor and these findings suggested that induction of HO-1 may be a useful prevention and treatment strategy against BVDV infection.
These findings suggest that bronchiolar epithelial cells and macrophages up-regulate Nrf2 (show NFE2L2 Antibodies) expression early in the course of infection, which results in increased expression of HO-1 within these cells.
investigation of molecular mechanisms of microvascular complications in diabetes/hyperglycemia: regulation of HO-1 gene expression in aortic endothelial cells by advanced glycation end products
Sickle blood increases endothelial heme oxygenase activity.
data provide evidence for the involvement of the thioredoxin/thioredoxin (show TXN Antibodies) receptor system, in the regulation of haem oxygenase-1 expression in aortic endothelial cells during pro-oxidant challenge
Heme oxygenase-1 induction modulates hypoxic pulmonary vasoconstriction through upregulation of ecSOD/SOD3 (show SOD3 Antibodies).
EET-mediated increase in HO-1 levels require PGC-1alpha (show PPARGC1A Antibodies) expression
Data suggest the a decrease in migration of hematopoietic stem progenitor cells (HSPCs) can be explained by impaired calcium release in phospholipase C (show PLC Antibodies)-beta2 (PLC (show HSPG2 Antibodies)-beta2) knockout (KO) mice and a high baseline level of heme oxygenase 1 (HO-1), an enzyme that negatively regulates cell migration.
HO-1 expression is upregulated by hydrogen-rich water in a mouse model of in fl ammatory bowel disease, which also inhibits inflammatory factors, and oxidative stress and ER stress
Results establish an essential role for the receptor CX3CR1 (show CX3CR1 Antibodies) in gut (show GUSB Antibodies) macrophages in resolving inflammation in the intestine, where it helps protects against colitis-associated cancer by regulating HMOX-1 expression.
study demonstrates that human respiratory syncytial virus (hRSV) infection can be modulated by the expression of HO-1 both in vitro and in vivo; thus, HO-1 activity may play a critical role during hRSV infection
This is the first study to dissect the mechanism by which the antiadipogenic and anti-inflammatory lipid, Epoxyeicosatrienoic acid, induces the PGC-1alpha (show PPARGC1A Antibodies) signaling cascade and reprograms the adipocyte phenotype by regulating mitochondrial function and HO-1 expression.
The findings suggest that HO-1 by modulating TLR9 (show TLR9 Antibodies) expression in PMCs promotes pleural innate immunity in MRSA (show MSR1 Antibodies) empyema.
HO-1 regulates not only cytokine/chemokine (show CCL1 Antibodies) production in pregnant uteri but also myeloid cell receptor numbers.
Administration of EET alters Wnt1 (show WNT1 Antibodies), NOV (show NOV Antibodies), and HO-1 signaling to prevent obesity-induced cardiomyopathy in obese mice.
Kidneys from circulation-restricted fetuses showed reduced heme oxygenase-1 mRNA.
Ligustrazine injection possesses notable protective effects on ischemia/reperfusion injury in rabbits by increasing the expression of HO-1 in lung.
Results add new evidence for the importance of HO-1 in the genesis and development of atherosclerosis and provide several possible mechanisms underlying the anti-atherosclerosis effects of HO-1
the effect of HO-1 on the progression and stabilization of vulnerable plaques and the possible mechanism
Heme-L-lysinate could attenuate atherosclerotic progression through upregulating HO-1 and HSP70 (show HSP70 Antibodies) expression and increasing CO production.
These results suggest that HO-1 is important in limiting in-stent stenosis and can be regarded as a new therapeutic target.
Statins showed anti-atherosclerotic effects mediated by HO-1/eNOS (show NOS3 Antibodies), restoring the [NO]/[ONOO(-)] imbalance and reducing lipid peroxidation.
HO-1/CO system was activated and may be one of the protective signal pathway during pulmonary ischemia-reperfusion injury in rabbits.
HO-1 contributes to vascular repair by increasing circulating endothelial progenitor cells (EPCs) derived from the bone marrow.
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family.
heme oxygenase (decycling) 1
, heme oxygenase 1
, heme oxygenase
, Heme oxygenase
, heat shock protein, 32-kD
, heat shock protein 32
, heme oxygenase (decyclizing) 1
, P32 protein
, heme oxygenase-1